Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.
The effect of iron depletion on chronic hepatitis C virus infection
M. Franchini,G. Targher,F. Capra,M. Montagnana,G. Lippi
Published 2008 in Hepatology International
ABSTRACT
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- Publication year
2008
- Venue
Hepatology International
- Publication date
2008-05-08
- Fields of study
Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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