Natural products with anti-aging potential: Affected targets and molecular mechanisms.

In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging. In line with this, SIRT1 protein levels are expanded in response to calorie restriction mimetics (CRM), in this way acting as autophagy inducers relevant to cancer prevention.

• Publication year

  2018

• Venue

  Biotechnology Advances

• Publication date

  2018-11-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.biotechadv.2018.03.012PMID 29597027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Caloric restriction is linked to cancer-related chronic inflammation in aging, and calorie restriction mimetics are associated with increased SIRT1 protein levels that act as autophagy inducers relevant to cancer prevention.

  Confidence 0.84

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• Natural products are described as promoting cellular longevity by inducing autophagy and lowering acetyl coenzyme A (AcCoA).

  Confidence 0.86

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• Polyphenols and other natural products are presented as external dietary interventions that influence age-related progression through epigenetic regulation and histone post-translational modification.

  Confidence 0.88

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review

• acetyl coenzyme a (accoa)

  metabolite

  A central acetyl-donor metabolite referenced in relation to longevity-related cellular regulation.

  Aliases: AcCoA, acetyl-CoA

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• autophagy

  cellular process

  A cellular recycling pathway that degrades and reuses intracellular components.

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• caloric restriction

  intervention

  Reduced calorie intake used as a physiological intervention relevant to aging biology.

  Aliases: CR

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• calorie restriction mimetics

  therapeutic agent

  Compounds or interventions that reproduce cellular responses associated with caloric restriction.

  Aliases: CRM

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• cancer prevention

  outcome

  The prevention of cancer discussed as a downstream health relevance of the mechanisms reviewed.

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• cancer-related chronic inflammation

  pathological process

  Persistent inflammatory signaling associated with cancer and aging contexts.

  Aliases: cancer related chronic inflammation

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• epigenetic-modulating diet

  diet

  A dietary pattern or intervention that affects gene regulation through epigenetic mechanisms.

  Aliases: epigenetic modulating diet

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• histone post-translational modification

  molecular process

  Chemical modification of histone proteins that changes chromatin behavior and gene regulation.

  Aliases: histone PTM, histone posttranslational modification

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• natural products

  compound

  Bioactive substances from natural sources considered in the paper as anti-aging interventions.

  Aliases: natural product

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• polyphenols

  compound

  Plant-derived phenolic compounds discussed here as dietary agents with anti-aging relevance.

  Aliases: polyphenol

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review
• sirt1 protein

  protein

  A sirtuin protein discussed as a regulator connected to longevity and autophagy signaling.

  Aliases: SIRT1

  박진우 (dztg5apj7m) extractionB (s683577b42) review뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) review

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