Screening for antiradical efficiency of 21 semi-synthetic derivatives of quercetin in a DPPH assay

Abstract The group of 21 novel semi-synthetic derivatives of quercetin was screened for the antiradical efficiency in a DPPH assay. The initial fast absorbance decrease of DPPH, corresponding to the transfer of the most labile H atoms, was followed by a much slower absorbance decline representing the residual antiradical activity of the antioxidant degradation products. Initial velocity of DPPH decolorization determined for the first 75-s interval was used as a marker of the antiradical activity. Application of the kinetic parameter allowed good discrimination between the polyphenolic compounds studied. The most efficient chloronaphthoquinone derivative (compound Ia) was characterized by antiradical activity higher than that of quercetin and comparable with that of trolox. Under the experimental conditions used, one molecule of Ia was found to quench 2.6±0.1 DPPH radicals.

• Publication year

  2013

• Venue

  Interdisciplinary Toxicology

• Publication date

  2013-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2478/intox-2013-0003PMID 24170974PMCID 3795316
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel quercetin derivatives: synthesis and screening for anti-oxidant activity and aldose reductase inhibition

  2012cited by this paper
• A joint application of spectroscopic, electrochemical and theoretical approaches in evaluation of the radical scavenging activity of 3-OH flavones and their iron complexes towards different radical species.

  2012cited by this paper
• Eye Lens in Aging and Diabetes: Effect of Quercetin

  2011cited by this paper
• Bioavailability of dietary flavonoids and phenolic compounds.

  2010cited by this paper
• Quercetin: potentials in the prevention and therapy of disease

  2008cited by this paper
• Health effects of quercetin: from antioxidant to nutraceutical.

  2008cited by this paper
• Quercetin and its derivatives: chemical structure and bioactivity - a review

  2008cited by this paper
• Radical scavenging ability of polyphenolic compounds towards DPPH free radical.

  2007cited by this paper
• SAR and QSAR of the antioxidant activity of flavonoids.

  2007cited by this paper
• The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides.

  2004cited by this paper
• Kinetic study of flavonoid reactions with stable radicals.

  2004cited by this paper
• Flavonoids: antioxidants or signalling molecules?

  2004cited by this paper
• Quantitative kinetic analysis of hydrogen transfer reactions from dietary polyphenols to the DPPH radical.

  2003cited by this paper
• Chemistry of the Antioxidant Effect of Polyphenols

  2002cited by this paper
• Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.

  2002cited by this paper
• Flavonoids: a review of probable mechanisms of action and potential applications.

  2001cited by this paper
• Flavonoid antioxidants.

  2001cited by this paper
• Flavonoids as antioxidants.

  2000cited by this paper
• Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships.

  1997cited by this paper
• Analogs or derivatives of quercetin (prodrug)

  1997cited by this paper
• Flavonoids as antioxidants: determination of radical-scavenging efficiencies.

  1990cited by this paper
• The Flavonoids—Advances in Research since 1980: : edited by J. B. Harborne. Chapman & Hall, London and New York, xiii+621 pp. £95.

  1989cited by this paper
• The Flavonoids: Advances in Research since 1980

  1988cited by this paper
• Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1.

  1988cited by this paper
• Antioxidant Determinations by the Use of a Stable Free Radical

  1958cited by this paper

• In vitro and in vivo evaluation of 1,4-bis-benzylpiperazine-2-carboxylic acid derivatives as potential multi-target directed ligands (MTDLs) anti-Alzheimer's agents.

  2025cites this paper
• Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease Using Conjugates of Serotonin with Sesquiterpene Lactones.

  2022cites this paper
• A new modified pterocarpan glycoside from Sophora flavescens

  2022cites this paper
• Novel Multitarget Hydroxamic Acids with a Natural Origin CAP Group against Alzheimer’s Disease: Synthesis, Docking and Biological Evaluation

  2021cites this paper
• New Spirocyclic Hydroxamic Acids as Effective Antiproliferative Agents.

  2020cites this paper
• ZNACZENIE KWERCETYNY JAKO ZWIĄZKU WSPOMAGAJĄCEGO WYDOLNOŚĆ W DIECIE SPORTOWCA

  2019cites this paper
• Quercetin based derivatives as sirtuin inhibitors.

  2019cites this paper
• Three Regioselectively Acylated Flavonoid Aglycone Derivatives in Equimolar Yield at One Blow

  2018cites this paper
• Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg.

  2017cites this paper
• Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases.

  2017cites this paper
• 3′-O-(3-Chloropivaloyl)quercetin, α-glucosidase inhibitor with multi-targeted therapeutic potential in relation to diabetic complications

  2016cites this paper
• 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent

  2015cites this paper
• QUERCETIN CONTENT AND ANTIOXIDANT ACTIVITY OF ARMENIAN CRATAEGUS LAEVIGATA, PLANTAGO MAJOR AND ARTEMISIA ABSINTHIUM PLANTS EXTRACTS

  2014cites this paper