Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism

Highlights ► Ghrelin requires GHS-R1a for its effect on hypothalamic, liver and adipose tissue AMPK activity. ► An intact ghrelin signalling pathway is required for the effects of cannabinoids on AMPK activity. ► Ghrelin and cannabinoids stimulate hypothalamic but inhibit liver and visceral fat AMPK. ► Treatment with HU210 at 20 ng/g significantly inhibited inguinal fat AMPK activity. ► We report the loss of inhibitory effects of ghrelin on liver AMPK activity in GHS-R1a KO mice.

• Publication year

  2013

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2013-01-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.mce.2012.11.007PMID 23178796PMCID 3566541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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