Identification of Human UDP-Glucuronosyltransferases Involved in N-Carbamoyl Glucuronidation of Lorcaserin

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Drug Metabolism And Disposition

• Publication date

  2012-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/dmd.111.043448PMID 22259019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of Human Cytochrome P450 and Flavin-Containing Monooxygenase Enzymes Involved in the Metabolism of Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine 2C Agonist

  2012cited by this paper
• A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial.

  2011cited by this paper
• Multicenter, placebo-controlled trial of lorcaserin for weight management.

  2010cited by this paper
• Identification of a Novel N-Carbamoyl Glucuronide: In Vitro, In Vivo, and Mechanistic Studies

  2010cited by this paper
• Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

  2009cited by this paper
• UGT3A: novel UDP-glycosyltransferases of the UGT superfamily

  2009cited by this paper
• Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite

  2009cited by this paper
• Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation.

  2008cited by this paper
• Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes

  2007influential reference
• Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.

  2007cited by this paper
• The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver

  2007cited by this paper
• The UDP-Glucuronosyltransferase 2B17 Gene Deletion Polymorphism: Sex-Specific Association with Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol Glucuronidation Phenotype and Risk for Lung Cancer

  2007cited by this paper
• Sulfinpyrazone C-Glucuronidation Is Catalyzed Selectively by Human UDP-Glucuronosyltransferase 1A9

  2006cited by this paper
• Reaction of primary and secondary amines to form carbamic acid glucuronides.

  2006cited by this paper
• Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro.

  2006cited by this paper
• METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

  2006cited by this paper
• BIOTRANSFORMATION OF A GABAA RECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUE N-CARBAMOYL METABOLITES

  2005cited by this paper
• SERTRALINE IS METABOLIZED BY MULTIPLE CYTOCHROME P450 ENZYMES, MONOAMINE OXIDASES, AND GLUCURONYL TRANSFERASES IN HUMAN: AN IN VITRO STUDY

  2005cited by this paper
• DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

  2004cited by this paper
• Glucuronidation of HMR1098 in human microsomes: evidence for the involvement of UGT1A1 in the formation of S-glucuronides.

  2003influential reference
• Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics.

  2003cited by this paper
• Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.

  2002cited by this paper
• Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.

  2002cited by this paper
• Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.

  2001cited by this paper
• Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.

  2001cited by this paper
• Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.

  2001cited by this paper
• O-Glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanol (NNAL) by human UDP-glucuronosyltransferases 2B7 and 1A9.

  2000cited by this paper
• Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

  2000cited by this paper
• Carbon dioxide but not bicarbonate inhibits N-nitrosation of secondary amines. Evidence for amine carbamates as protecting entities.

  2000cited by this paper
• Characterization of UDP-glucuronosyltransferases active on steroid hormones.

  1999cited by this paper
• Drug-metabolizing enzymes in pharyngeal mucosa and in oropharyngeal cancer tissue.

  1997cited by this paper
• The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

  1997cited by this paper
• Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids*

  1996cited by this paper
• Formation of a carbamoyl glucuronide conjugate of carvedilol in vitro using dog and rat liver microsomes.

  1992cited by this paper
• Drug glucuronidation in humans.

  1991cited by this paper
• Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline.

  1989cited by this paper
• Benzazepine metabolism revisited. Evidence for the formation of novel amine conjugates.

  1988cited by this paper

• Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib

  2024cites this paper
• Lorcaserin for Dravet Syndrome: A Potential Advance Over Fenfluramine?

  2022cites this paper
• Metabolism and in vitro drug–drug interaction assessment of viloxazine

  2020cites this paper
• Chemistry, Analysis, Pharmacokinetics and Pharmacodynamics aspects of Lorcaserin, a selective serotonin 5-HT2C receptor agonist: An update.

  2020cites this paper
• The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.

  2019cites this paper
• Humane Enzyme für die organische Synthese

  2018cites this paper
• Human Enzymes for Organic Synthesis

  2018cites this paper
• Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex

  2018cites this paper
• Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

  2018cites this paper
• Obesity: Pathogenesis and emerging targets for drug development

  2017cites this paper
• The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants

  2017cites this paper
• Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes

  2016cites this paper
• Physiological scaling factors and mechanistic models for prediction of renal clearance from in vitro data

  2016cites this paper
• Influence of polymorphisms of UDP-glycosyltransferases (UGT) 2B family genes UGT2B15, UGT2B17 and UGT2B28 on the development of prostate cancer in Korean men

  2016cites this paper
• Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation

  2016cites this paper
• Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine

  2016cites this paper
• A Validated UPLC-MS-MS Assay for the Rapid Determination of Lorcaserin in Plasma and Brain Tissue Samples.

  2016cites this paper
• Safety of Anti-Obesity Drugs Approved for Long-Term Use

  2015cites this paper
• New and Emerging Drug Molecules Against Obesity

  2014cites this paper
• Lorcaserin: A novel antiobesity drug

  2014cites this paper
• Transcriptional regulation of human UDP-glucuronosyltransferase genes

  2014cites this paper
• Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats

  2014cites this paper
• Lorcaserin: a novel serotonin 2C agonist for the treatment of obesity

  2013cites this paper
• DMD049197 291..295

  2013cites this paper
• Tissue Distribution and Relative Gene Expression of UDP-Glucuronosyltransferases (2B7, 2B15, 2B17) in the Human Fetus

  2013cites this paper
• Lorcaserin Hydrochloride

  2012cites this paper