Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2017-01-17

• Fields of study

  Medicine

• Identifiers
  DOI 10.1128/AAC.02391-16PMID 28096166PMCID PMC5365704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparative Pharmacokinetic Profiling of Different Polymyxin B Components

  2016cited by this paper
• Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model

  2015cited by this paper
• Risk factors for nephrotoxicity onset associated with polymyxin B therapy.

  2015cited by this paper
• The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells

  2014cited by this paper
• Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers.

  2014cited by this paper
• In Vitro Assessment and Multicenter Cohort Study of Comparative Nephrotoxicity Rates Associated with Colistimethate versus Polymyxin B Therapy

  2014cited by this paper
• To study the clinical efficacy and nephrotoxicity along with the risk factors for acute kidney injury associated with parenteral polymyxin B

  2013cited by this paper
• Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

  2013cited by this paper
• Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin

  2013cited by this paper
• Vitamin D Transport Proteins Megalin and Disabled-2 Are Expressed in Prostate and Colon Epithelial Cells and Are Induced and Activated by All-Trans-Retinoic Acid

  2013cited by this paper
• Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats

  2012cited by this paper
• Pharmacokinetics and Renal Disposition of Polymyxin B in an Animal Model

  2012cited by this paper
• Characterization of Polymyxin B-Induced Nephrotoxicity: Implications for Dosing Regimen Design

  2012cited by this paper
• New insights into the roles of megalin/LRP2 and the regulation of its functional expression.

  2011cited by this paper
• Prevalence and Risk Factors for Acute Kidney Injury Associated with Parenteral Polymyxin B Use

  2009cited by this paper
• Pharmacokinetics of intravenous polymyxin B in critically ill patients.

  2008cited by this paper
• Polymyxin antibiotics for gram-negative infections.

  2007cited by this paper
• Role of megalin and cubilin in renal physiology and pathophysiology.

  2007cited by this paper
• Polymyxin B Nephrotoxicity and Efficacy against Nosocomial Infections Caused by Multiresistant Gram-Negative Bacteria

  2003cited by this paper
• Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation*

  2002cited by this paper
• Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome.

  2002cited by this paper
• Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg).

  1998cited by this paper
• Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg).

  1998cited by this paper
• Tissue Distribution of Human gp330/Megalin, a Putative Ca2+-sensing Protein

  1997cited by this paper
• Specific effect of maleate on an apical membrane glycoprotein (gp330) in proximal tubule of rat kidneys.

  1996cited by this paper
• Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.

  1995cited by this paper
• Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.

  1992cited by this paper

• Evaluation of polymyxin B-associated acute kidney injury in carbapenem-resistant infections: A systematic review and meta-analysis

  2026cites this paper
• Structure function and design of polymyxins to enable safer and more potent anti Gram negative agents.

  2026cites this paper
• Molecular mechanisms attributed to colistin renal proximal tubular epithelial cytotoxicity

  2025cites this paper
• Acute kidney injury of intravenous colistin sulfate compared with colistimethate sodium: a real-world, retrospective cohort study

  2025cites this paper
• Factors Associated with Successful Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infections Using Intravenous Colistin Sulfate in China: A Real-World Retrospective Study

  2025cites this paper
• Natural product inspired antibiotics approved for human use - 1943 to 2025.

  2025cites this paper
• Polymyxin B in The Treatment of Infections Caused by Multidrug-Resistant Gram-Negative Bacteria in Children: A Retrospective Case Series and A Literature Review

  2025cites this paper
• Advances in the clinical treatment of multidrug-resistant pathogens using polymyxins.

  2024cites this paper
• Effectiveness and Nephrotoxicity of Polymyxin B among Intensive Care Unit Patients: A Clinical Evaluation

  2024cites this paper
• Evaluating nephrotoxicity reduction in a novel polymyxin B formulation: insights from a 3D kidney-on-a-chip model

  2024cites this paper
• Mechanisms of Gelofusine Protection against Polymyxin B-associated Renal Injury.

  2024cites this paper
• Tobramycin Reduces Pulmonary Toxicity of Polymyxin B via Inhibiting the Megalin-Mediated Drug Uptake in the Human Lung Epithelial Cells

  2024cites this paper
• Recent Advances in the Development of Polymyxin Antibiotics: 2010–2023

  2024cites this paper
• Comparative pharmacokinetics of polymyxin B in critically ill elderly patients with extensively drug-resistant gram-negative bacteria infections

  2024cites this paper
• In vitro activity of ceftazidime/avibactam, imipenem/relebactam and meropenem/vaborbactam alone or in combination with polymyxin B against carbapenem resistant Acinetobacter baumannii

  2023cites this paper
• Zileuton ameliorates aminoglycoside and polymyxin-associated acute kidney injury in an animal model.

  2023cites this paper
• Polymyxin B-Modified Fosfomycin Liposomes Target Gram-Negative Bacteria and Exert Synergistic Antibacterial Effect

  2023cites this paper
• Population pharmacokinetics and limited sampling strategies of polymyxin B in critically ill patients.

  2023cites this paper
• Population pharmacokinetics of polymyxin B in patients with liver dysfunction

  2023cites this paper
• In vitro analysis of synergistic combination of polymyxin B with 12 other antibiotics against MDR Acinetobacter baumannii isolated from a Chinese tertiary hospital

  2022cites this paper
• Polymyxin B-Associated Nephrotoxicity and Its Predictors: A Retrospective Study in Carbapenem-Resistant Gram-Negative Bacterial Infections

  2022cites this paper
• Higher incidence of neurotoxicity and skin hyperpigmentation in renal transplant patients treated with polymyxin B

  2022cites this paper
• Correlation between the drug concentration of polymyxin B and polymyxin B‐associated acute kidney injury in critically ill patients: A prospective study

  2022cites this paper
• DDDT_A_287332 611..616

  2021cites this paper
• Urinary Metabolomics from a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury

  2021cites this paper
• Polymyxin B-Induced Kidney Injury Assessment of a Novel Formulation of Polymyxin B (VRP-034) in Rats

  2021cites this paper
• Rescuing the Last-Line Polymyxins: Achievements and Challenges

  2021cites this paper
• Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity

  2021cites this paper
• Polymyxin-induced nephrotoxicity and its predictors: a systematic review and meta-analysis of studies conducted using RIFLE criteria of acute kidney injury.

  2020cites this paper
• A Review of the Clinical Pharmacokinetics of Polymyxin B

  2019cites this paper
• Pharmacokinetics of Polymyxins in Animals.

  2019cites this paper
• Mechanisms of Polymyxin-Induced Nephrotoxicity.

  2019cites this paper
• Structure-Function Studies of Polymyxin B Lipononapeptides

  2019cites this paper
• A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion

  2018cites this paper
• Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.

  2018cites this paper
• Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

  2018cites this paper
• Biomolecular interactions of amphotericin B nanomicelles with serum albumins: A combined biophysical and molecular docking approach.

  2018cites this paper
• Population Pharmacokinetics of Polymyxin B

  2018cites this paper
• Gelofusine Ameliorates Colistin-Induced Nephrotoxicity

  2017cites this paper
• Recent advances and perspectives in the design and development of polymyxins.

  2017cites this paper