Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cancer Letters

• Publication date

  2017-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.canlet.2017.09.002PMID 28923396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells

  2017cited by this paper
• Rationale for stimulator of interferon genes-targeted cancer immunotherapy.

  2017cited by this paper
• Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

  2017cited by this paper
• Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

  2016cited by this paper
• A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

  2016cited by this paper
• Optimizing mouse models for precision cancer prevention

  2016cited by this paper
• Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model

  2016cited by this paper
• Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation.

  2016cited by this paper
• Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked.

  2016cited by this paper
• Smac mimetic sensitizes renal cell carcinoma cells to interferon-α-induced apoptosis.

  2016cited by this paper
• Promises and Challenges of Smac Mimetics as Cancer Therapeutics

  2015cited by this paper
• Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly.

  2014cited by this paper
• Synergistic interaction of Smac mimetic and IFNα to trigger apoptosis in acute myeloid leukemia cells.

  2014cited by this paper
• Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response

  2014cited by this paper
• Regulated necrosis: the expanding network of non-apoptotic cell death pathways

  2014cited by this paper
• Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

  2014cited by this paper
• MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

  2014cited by this paper
• Therapeutic exploitation of necroptosis for cancer therapy.

  2014cited by this paper
• Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis

  2013cited by this paper
• Targeting IAP proteins for therapeutic intervention in cancer

  2012cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis

  2011cited by this paper
• Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

  2011cited by this paper
• Molecular mechanisms of necroptosis: an ordered cellular explosion

  2010cited by this paper
• Drug combination studies and their synergy quantification using the Chou-Talalay method.

  2010cited by this paper
• Tumor resistance to apoptosis

  2009cited by this paper
• The IRF family transcription factors in immunity and oncogenesis.

  2008cited by this paper
• IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

  2007cited by this paper
• Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

  2007cited by this paper
• IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

  2007cited by this paper
• Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.

  2000cited by this paper

• Metabolic cell death in cancer: mechanisms and therapeutic potential

  2025cites this paper
• Study on Smac promoting mitochondrial pathway apoptosis and muscle tenderization during postmortem aging of Tibetan sheep meat.

  2025cites this paper
• IFN-γ enhances Poly(I:C)-induced necroptosis and immunogenic cell death via TLR3 upregulation in cholangiocarcinoma cells.

  2025cites this paper
• Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control

  2025cites this paper
• IFN-γ Approaches in Tumor Suppression, Its Challenges, and Future Directions: A Review of Recent Advances

  2025cites this paper
• SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

  2024cites this paper
• Identification and Modeling of Necroptosis-Related Genes Associated with the Prognosis of Breast Cancer

  2024cites this paper
• Association between High Interferon-Gamma Production in Avian Tuberculin-Stimulated Blood from Mycobacterium avium subsp. paratuberculosis-Infected Cattle and Candidate Genes Implicated in Necroptosis

  2023cites this paper
• Upregulation of cIAP1 induced by AZD8330 alleviates osteoarthritis progression by inhibiting the RIP1-associated necrosis signaling pathway.

  2023cites this paper
• Global publication trends and research trends of necroptosis application in tumor: A bibliometric analysis

  2023cites this paper
• The diverse pancreatic tumor cell-intrinsic response to IFNγ is determined by epigenetic heterogeneity.

  2023cites this paper
• A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer

  2022cites this paper
• Mode of Actions of Bile Acids in Avoidance of Colorectal Cancer Development; and their Therapeutic Applications in Cancers - A Narrative Review

  2022cites this paper
• Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer

  2022cites this paper
• Conjugation of the Fn14 ligand to a SMAC mimetic selectively suppresses experimental squamous cell carcinoma in mice.

  2022cites this paper
• Necroptosis pathways in tumorigenesis.

  2022cites this paper
• Targeting necroptosis as an alternative strategy in tumor treatment: From drugs to nanoparticles.

  2022cites this paper
• Novel smac mimetic ASTX660 (Tolinapant) and TNF-α synergistically induce necroptosis in bladder cancer cells in vitro upon apoptosis inhibition.

  2022cites this paper
• Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review

  2022cites this paper
• The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells

  2021cites this paper
• MLKL in cancer: more than a necroptosis regulator

  2021cites this paper
• Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC

  2021cites this paper
• MiRNA-124 regulates the sensitivity of renal cancer cells to cisplatin-induced necroptosis by targeting the CAPN4-CNOT3 axis

  2021cites this paper
• A novel neurodegenerative spectrum disorder in patients with MLKL deficiency

  2020cites this paper
• Double agents of cell death: novel emerging functions of apoptotic regulators

  2020cites this paper
• The effect of DEBIO 1143 usage alone or in combination with Tamoxifen on estrogen receptor positive breast cancer cell lines.

  2020cites this paper
• An Updated Review of Smac Mimetics, LCL161, Birinapant, and GDC-0152 in Cancer Treatment

  2020cites this paper
• SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway

  2020cites this paper
• RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage

  2020cites this paper
• Interferon-γ induces the cell surface exposure of phosphatidylserine by activating the protein MLKL in the absence of caspase-8 activity

  2019cites this paper
• The role of necroptosis in cancer: A double-edged sword?

  2019cites this paper
• Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.

  2019cites this paper
• Cell cycle arrest in mitosis promotes interferon-induced necroptosis

  2019cites this paper
• HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.

  2019cites this paper
• A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy

  2019cites this paper
• Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening

  2019cites this paper
• Current translational potential and underlying molecular mechanisms of necroptosis

  2019cites this paper
• Zinc oxide nanoparticles induce necroptosis and inhibit autophagy in MCF-7 human breast cancer cells

  2019cites this paper
• Comparing the effects of different cell death programs in tumor progression and immunotherapy

  2018cites this paper
• RIPK1 and RIPK3 – emerging targets in cancer?

  2018cites this paper
• Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

  2018cites this paper
• Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling.

  2018cites this paper
• Interferon gamma in cancer immunotherapy

  2018cites this paper