IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2017-04-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1701420114PMID 28416699PMCID PMC5422816
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper
• Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release.

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