Loss of p38γ MAPK induces pleiotropic mitotic defects and massive cell death

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Cell Science

• Publication date

  2011-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.068254PMID 21172807
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Silencing of Polo-Like Kinase (Plk) 1 via siRNA Causes Inhibition of Growth and Induction of Apoptosis in Human Esophageal Cancer Cells

  2008cited by this paper
• Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis

  2008cited by this paper
• Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

  2008cited by this paper
• Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

  2008cited by this paper
• Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression

  2008influential reference
• Mitogen-activated protein kinases in cell-cycle control

  2007cited by this paper
• A Functional Role for p38 MAPK in Modulating Mitotic Transit in the Absence of Stress*

  2007influential reference
• Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.

  2007cited by this paper
• Lysed cell models and isolated chromosomes for the study of kinetochore/centromere biochemistry in vitro.

  2006cited by this paper
• Role of MAPKs in development and differentiation: lessons from knockout mice.

  2006cited by this paper
• Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.

  2006cited by this paper
• Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases

  2005influential reference
• A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity.

  2005cited by this paper
• A Novel Role of p38α MAPK in Mitotic Progression Independent of Its Kinase Activity

  2005cited by this paper
• Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development.

  2005cited by this paper
• Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.

  2005cited by this paper
• The p38-Mediated Stress-Activated Checkpoint: A Rapid Response System for Delaying Progression through Antephase and Entry into Mitosis

  2005influential reference
• Small interfering RNA-mediated Polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals.

  2005cited by this paper
• Silencing of polo‐like kinase (Plk) 1 via siRNA causes induction of apoptosis and impairment of mitosis machinery in human prostate cancer cells: implications for the treatment of prostate cancer

  2005cited by this paper
• Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity

  2004cited by this paper
• Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

  2003cited by this paper
• Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

  2003cited by this paper
• Xp38γ/SAPK3 promotes meiotic G2/M transition in Xenopus oocytes and activates Cdc25C

  2003cited by this paper
• Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.

  2003cited by this paper
• MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α

  2002influential reference
• Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells.

  2002cited by this paper
• p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony.

  2002influential reference
• MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

  2002cited by this paper
• Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina.

  2002cited by this paper
• Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

  2001cited by this paper
• p38 MAPK signalling cascades: ancient roles and new functions

  2000cited by this paper
• Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5

  2000cited by this paper
• The morphology of apoptosis

  2000influential reference
• CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

  2000cited by this paper
• Cytoplasmic dynein and dynactin in cell division and intracellular transport.

  1999cited by this paper
• Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest.

  1998cited by this paper
• Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

  1998cited by this paper
• Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)*

  1996cited by this paper
• ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

  1996cited by this paper
• The primary structure of p38 gamma: a new member of p38 group of MAP kinases.

  1996cited by this paper
• A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.

  1994cited by this paper

• Combination of QSAR Modeling and Hybrid-Based Consensus Scoring to Identify Dual-Targeting Inhibitors of PLK1 and p38γ

  2023cites this paper
• The Role of p38γ in Cancer: From review to outlook

  2021cites this paper
• Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process

  2021cites this paper
• Hydrogen sulfide improves ox-LDL-induced expression levels of Lp-PLA2 in THP-1 monocytes via the p38MAPK pathway

  2021cites this paper
• The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

  2020cites this paper
• IL-1 (cid:2) -induced and p38 MAPK -dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

  2020cites this paper
• miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4

  2019cites this paper
• Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies

  2019cites this paper
• Impact of p38γ mitogen-activated protein kinase (MAPK) on MDA-MB-231 breast cancer cells using metabolomic approach.

  2019cites this paper
• MCPH1 is essential for cellular adaptation to the G 2 -phase decatenation checkpoint

  2019cites this paper
• MCPH1 is essential for cellular adaptation to the G2‐phase decatenation checkpoint

  2019cites this paper
• Kinases Involved in Both Autophagy and Mitosis

  2017cites this paper
• Transcriptome Sequencing Reveals Key Pathways and Genes Associated with Cisplatin Resistance in Lung Adenocarcinoma A549 Cells

  2017cites this paper
• Mechanisms of Chromosome Congression during Mitosis

  2017cites this paper
• IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

  2017cites this paper
• Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery

  2016cites this paper
• Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ*

  2016cites this paper
• p38 MAP kinases in the heart.

  2016cites this paper
• Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma

  2016cites this paper
• Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis

  2015cites this paper
• BI2536--A PLK inhibitor augments paclitaxel efficacy in suppressing tamoxifen induced senescence and resistance in breast cancer cells.

  2015cites this paper
• Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation, and Cell Cycle: Role and Targeting

  2014cites this paper
• Cross-talk between the circadian clock and the cell cycle in cancer

  2014cites this paper
• Etude structurale et fonctionnelle de la phosphatase humaine PTPN4

  2014cites this paper
• Is p38γ MAPK a metastasis-promoting gene or an oncogenic property-maintaining gene?

  2013cites this paper
• Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.

  2013cites this paper
• p38γ overexpression in gliomas and its role in proliferation and apoptosis

  2013cites this paper
• Global Analysis of Serine/Threonine and Tyrosine Protein Phosphatase Catalytic Subunit Genes in Neurospora crassa Reveals Interplay Between Phosphatases and the p38 Mitogen-Activated Protein Kinase

  2013cites this paper
• MAPK-activated protein kinase 2 (MK2) in neuroinflammation, Hsp27 phosphorylation and cell cycle: Role and Targeting

  2013cites this paper
• The role of ROS toxicity in spontaneous aneuploidy in cultured cells.

  2013cites this paper
• p38γ Mitogen-activated Protein Kinase (MAPK) Confers Breast Cancer Hormone Sensitivity by Switching Estrogen Receptor (ER) Signaling from Classical to Nonclassical Pathway via Stimulating ER Phosphorylation and c-Jun Transcription*

  2012cites this paper
• p38γ Mitogen-activated Protein Kinase Signals through Phosphorylating Its Phosphatase PTPH1 in Regulating Ras Protein Oncogenesis and Stress Response*

  2012cites this paper
• Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array.

  2012cites this paper
• New Insights into the p38γ and p38δ MAPK Pathways

  2011cites this paper
• Spatio‐temporal composition of the mitotic Chromosomal Passenger Complex detected using in situ proximity ligation assay

  2011cites this paper