CDC6 (cell division cycle 6 homolog (S. cerevisiae))

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Atlas of genetics and cytogenetics in oncology and haematology

• Publication date

  2011-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4267/2042/38568
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• CDC6: from DNA replication to cell cycle checkpoints and oncogenesis.

  2008cited by this paper
• Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage.

  2007cited by this paper
• Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  2006cited by this paper
• Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability

  2006cited by this paper
• The functional role of Cdc6 in S–G2/M in mammalian cells

  2006cited by this paper
• Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

  2006cited by this paper
• Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase–mediated apoptosis of HeLa cells

  2006cited by this paper
• CDKs give Cdc6 a license to drive into S phase.

  2005cited by this paper
• p53-Dependent Regulation of Cdc6 Protein Stability Controls Cellular Proliferation

  2005cited by this paper
• Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix

  2005cited by this paper
• CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.

  2005cited by this paper
• Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells.

  2005cited by this paper
• The Regulated Association of Cdt1 with Minichromosome Maintenance Proteins and Cdc6 in Mammalian Cells*

  2004cited by this paper
• Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.

  2004cited by this paper
• Down to the origin: Cdc6 protein and the competence to replicate.

  2003cited by this paper
• Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1

  2003cited by this paper
• A p53-dependent checkpoint pathway prevents rereplication.

  2003cited by this paper
• Down-regulation of Cdc6, a Cell Cycle Regulatory Gene, in Prostate Cancer*

  2002cited by this paper
• Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

  2002cited by this paper
• Immunohistochemical localization of cdc6 in squamous and glandular neoplasia of the uterine cervix.

  2002cited by this paper
• Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast.

  2002cited by this paper
• Nuclear Organization of DNA Replication Initiation Proteins in Mammalian Cells*

  2002cited by this paper
• Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle.

  2002cited by this paper
• Multiple Mechanisms Regulate Subcellular Localization of Human CDC6*

  2001cited by this paper
• Cdc6 expression as a marker of proliferative activity in brain tumors.

  2001cited by this paper
• Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.

  2000cited by this paper
• Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells.

  2000cited by this paper
• Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process.

  2000cited by this paper
• Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

  2000cited by this paper
• Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.

  1999cited by this paper
• Cell Cycle Regulation of Human CDC6 Protein

  1999cited by this paper
• Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization

  1999cited by this paper
• Identification of the sequence responsible for the nuclear localization of human Cdc6

  1999cited by this paper
• The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.

  1999cited by this paper
• Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F

  1998cited by this paper
• Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

  1998cited by this paper
• Cell Cycle-Regulated Expression of MammalianCDC6 Is Dependent on E2F

  1998cited by this paper
• Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

  1998cited by this paper
• A human protein related to yeast Cdc6p.

  1997cited by this paper

• Prospect of reprogramming replication licensing for cancer drug development.

  2021cites this paper
• Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

  2011cites this paper
• Jcb: Article

  year unknowncites this paper