Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole‐induced epilepsy through the induction of Homer1a

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Neurochemistry

• Publication date

  2018-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/jnc.14274PMID 29222951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

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  2015cited by this paper
• Molecular mechanisms of epilepsy

  2015cited by this paper
• Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells*

  2015cited by this paper
• A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.

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  2014cited by this paper
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  2014cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Identification of new epilepsy treatments: Issues in preclinical methodology

  2012cited by this paper
• Drug-resistant epilepsy.

  2011cited by this paper
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  2011cited by this paper
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  2011influential reference
• Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

  2011cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008influential reference
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  2007cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Kindling and status epilepticus models of epilepsy: rewiring the brain.

  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  1999cited by this paper
• Pentylenetetrazole (PTZ)-induced c-fos expression in the hippocampus of kindled rats is suppressed by concomitant treatment with naloxone.

  1998cited by this paper
• Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses.

  1996cited by this paper
• Suppressed epileptogenesis in BDNF mutant mice.

  1995cited by this paper
• Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus.

  1993cited by this paper
• Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis.

  1991cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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• Blocking salt‐inducible kinases with YKL‐06‐061 prevents PTZ‐induced seizures in mice

  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2019cites this paper
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  2019cites this paper
• [Exploring Molecular Targets for Epilepsy Treatment from the Perspective of Neuronal Homeostasis].

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  2019cites this paper
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