Itch genetically interacts with Notch1 in a mouse autoimmune disease model.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Human Molecular Genetics

• Publication date

  2006-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/DDL425PMID 17095521
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch signaling is an important regulator of type 2 immunity

  2005cited by this paper
• The nervous system and innate immunity: the neuropeptide connection.

  2005cited by this paper
• The Notch Regulator Numb Links the Notch and TCR Signaling Pathways1

  2005cited by this paper
• Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

  2005cited by this paper
• Notch1 co‐localizes with CD4 on activated T cells and Notch signaling is required for IL‐10 production

  2005cited by this paper
• Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

  2005cited by this paper
• Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.

  2004cited by this paper
• Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

  2004cited by this paper
• Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.

  2004cited by this paper
• Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

  2004cited by this paper
• Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation.

  2004cited by this paper
• Notch regulation of lymphocyte development and function

  2004cited by this paper
• Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

  2004cited by this paper
• Notch Governing Mature T Cell Differentiation

  2004cited by this paper
• The Anti-apoptotic Effect of Notch-1 Requires p56lck-dependent, Akt/PKB-mediated Signaling in T Cells*

  2004cited by this paper
• Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.

  2003cited by this paper
• The role of the endosomal/ lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective

  2003cited by this paper
• Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

  2003cited by this paper
• Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis.

  2003cited by this paper
• BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

  2002cited by this paper
• A Reassessment of the Effect of Activated Notch1 on CD4 and CD8 T Cell Development1

  2002cited by this paper
• Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm.

  2002cited by this paper
• Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

  2002cited by this paper
• Notch: a membrane-bound transcription factor.

  2002cited by this paper
• Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation1

  2001cited by this paper
• Autoimmunity and lymphoma: tribulations of B cells

  2001cited by this paper
• Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

  2001cited by this paper
• T cell-specific loss of Pten leads to defects in central and peripheral tolerance.

  2001cited by this paper
• Activated p56lck Directs Maturation of Both CD4 and CD8 Single-Positive Thymocytes1

  2001cited by this paper
• Akt Inhibits the Orphan Nuclear Receptor Nur77 and T-cell Apoptosis*

  2001cited by this paper
• The ubiquitin system

  2000cited by this paper
• Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes.

  2000cited by this paper
• Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1.

  2000cited by this paper
• Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

  2000cited by this paper
• Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase*

  2000cited by this paper
• Notch signaling in T cell development.

  2000cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Cutting edge: protective effects of notch-1 on TCR-induced apoptosis.

  1999cited by this paper
• Arbiter of differentiation and death: Notch signaling meets apoptosis

  1999cited by this paper
• The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

  1998cited by this paper
• The ubiquitin system.

  1998cited by this paper
• Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling.

  1998cited by this paper
• Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

  1997cited by this paper
• Epidemiology and estimated population burden of selected autoimmune diseases in the United States.

  1997cited by this paper
• An activated form of Notch influences the choice between CD4 and CD8 T cell lineages.

  1996cited by this paper
• The C2 domain calcium‐binding motif: Structural and functional diversity

  1996cited by this paper
• Structure and function of the WW domain.

  1996cited by this paper
• A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection.

  1995cited by this paper
• Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.

  1995cited by this paper
• Thymic tumorigenesis induced by overexpression of p56lck.

  1991cited by this paper
• Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus

  1982cited by this paper

• A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis

  2025cites this paper
• E3-ubiquitin ligases and recent progress in osteoimmunology

  2023cites this paper
• E3 ubiquitin ligase on the biological properties of hematopoietic stem cell

  2023cites this paper
• Circular RNA ITCH: An Emerging Multifunctional Regulator

  2022cites this paper
• Protein ubiquitination in T cell development

  2022cites this paper
• E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation

  2021cites this paper
• Regulation of Notch signaling by E3 ubiquitin ligases

  2021cites this paper
• Itch regulation of innate and adaptive immune responses in mice and humans

  2020cites this paper
• The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses

  2019cites this paper
• Itch attenuates CD4 T‐cell proliferation in mice by limiting WBP2 protein stability

  2019cites this paper
• Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation

  2019cites this paper
• Regulation of autoimmune disease by the E3 ubiquitin ligase Itch.

  2019cites this paper
• Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure

  2019cites this paper
• Early‐onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms

  2018cites this paper
• Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch

  2017cites this paper
• Characterizing the Role of the E3 Ligase ITCH in Gut Mucosal Homeostasis

  2017influential citation
• Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

  2017cites this paper
• Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway

  2016cites this paper
• Regulation of Notch Signaling Through Intracellular Transport.

  2016cites this paper
• Advantages of Extracellular Ubiquitin in Modulation of Immune Responses

  2016cites this paper
• From Primary Immunodeficiency to Autoimmunity: How Extreme Situations Highlight the Main Genetic Factors Involved in Autoimmune Disease

  2016cites this paper
• Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

  2015influential citation
• The E3 ligase Itch in immune regulation and beyond

  2015cites this paper
• Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

  2013cites this paper
• The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation

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  2013cites this paper
• Ubiquitinations in the Notch Signaling Pathway

  2013cites this paper
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  2011cites this paper
• To go or not to go: the “Itchy” effect on the destiny of hematopoietic stem cells

  2011cites this paper
• A cell autonomous role for the Notch ligand Delta‐like 3 in αβ T‐cell development

  2011cites this paper
• Future Perspectives: Therapeutic Targeting of Notch Signalling May Become a Strategy in Patients Receiving Stem Cell Transplantation for Hematologic Malignancies

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• Signalling of E3 ubiquitin-protein ligases in the regulation of priming and tolerance of T cells

  2010cites this paper
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• Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

  2010cites this paper
• Experimental Models of Itch

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• Phosphatidylinositol 3-Kinase Signaling in Thymocytes: The Need for Stringent Control

  2010cites this paper
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  2009cites this paper
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  2009cites this paper
• PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

  2009cites this paper
• E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?

  2008cites this paper
• Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

  2008cites this paper
• In vivo consequences of deleting EGF repeats 8–12 including the ligand binding domain of mouse Notch1

  2008cites this paper
• Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes

  2008cites this paper
• Itchy mice: the identification of a new pathway for the development of autoimmunity.

  2008cites this paper
• Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes.

  2008cites this paper
• AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

  2008cites this paper
• Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology - Preface

  2008cites this paper
• The Immune Synapse as a Novel Target for Therapy

  2008cites this paper
• The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance.

  2007cites this paper
• The Nedd4-like family of E3 ubiquitin ligases and cancer

  2007cites this paper