Gut Microbiota: Association with NAFLD and Metabolic Disturbances

Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia. Recent lines of evidence have demonstrated a role of gut microbiota in insulin resistance, obesity, and associated metabolic disturbances, raising the interest in its relationship with NAFLD pathogenesis. Therefore, intestinal microbiota has emerged as a potential factor involved in NAFLD, through different pathways, including its influence in energy storage, lipid and choline metabolism, ethanol production, immune balance, and inflammation. The main objective of this review is to address the pathogenic association of gut microbiota to NAFLD. This comprehension may allow the development of integrated strategies to modulate intestinal microbiota in order to treat NAFLD.

• Publication year

  2015

• Venue

  BioMed Research International

• Publication date

  2015-05-19

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2015/979515PMID 26090468PMCID 4452311
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Non-alcoholic fatty liver disease.

  2016cited by this paper
• Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non‐alcoholic steatohepatitis

  2014influential reference
• Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

  2014influential reference
• Lactobacillus rhamnosus GG Protects against Non-Alcoholic Fatty Liver Disease in Mice

  2014influential reference
• Non-alcoholic fatty liver disease

  2014cited by this paper
• The Gordian Knot of dysbiosis, obesity and NAFLD

  2013cited by this paper
• Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease.

  2013influential reference
• Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways.

  2013influential reference
• Molecular Characterization of the Fecal Microbiota in Patients with Nonalcoholic Steatohepatitis – A Longitudinal Study

  2013cited by this paper
• Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.

  2013cited by this paper
• Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula.

  2013influential reference
• Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

  2013influential reference
• Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice.

  2012influential reference
• Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

  2012influential reference
• Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

  2012cited by this paper
• Gut--liver axis: the impact of gut microbiota on non alcoholic fatty liver disease.

  2012cited by this paper
• Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

  2012influential reference
• Bacteroides uniformis CECT 7771 Ameliorates Metabolic and Immunological Dysfunction in Mice with High-Fat-Diet Induced Obesity

  2012cited by this paper
• GLP-1 Receptor Agonist and Non-Alcoholic Fatty Liver Disease

  2012cited by this paper
• Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

  2012influential reference
• Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis.

  2012influential reference
• Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine.

  2012influential reference
• Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.

  2011influential reference
• Non‐alcoholic steatohepatitis‐induced fibrosis: Toll‐like receptors, reactive oxygen species and Jun N‐terminal kinase

  2011cited by this paper
• Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008.

  2011cited by this paper
• Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults

  2011cited by this paper
• A human gut microbial gene catalogue established by metagenomic sequencing

  2010cited by this paper
• Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

  2010cited by this paper
• Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.

  2009cited by this paper
• Non alcoholic fatty liver disease and metabolic syndrome.

  2009cited by this paper
• Pathogenesis of non-alcoholic fatty liver disease

  2009cited by this paper
• Toll‐like receptor 4 is involved in the development of fructose‐induced hepatic steatosis in mice

  2009influential reference
• Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management

  2009cited by this paper
• Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

  2009influential reference
• Toll-like receptors as targets in chronic liver diseases

  2009cited by this paper
• High Prevalence of Small Intestinal Bacterial Overgrowth in Patients with Morbid Obesity: A Contributor to Severe Hepatic Steatosis

  2008cited by this paper
• Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

  2008cited by this paper
• Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

  2007influential reference
• Rodent nutritional model of steatohepatitis: Effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency

  2006cited by this paper
• Microbial ecology: Human gut microbes associated with obesity

  2006cited by this paper
• Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

  2006influential reference
• An obesity-associated gut microbiome with increased capacity for energy harvest

  2006cited by this paper
• Obesity alters gut microbial ecology.

  2005cited by this paper
• The gut microbiota as an environmental factor that regulates fat storage.

  2004influential reference
• Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans.

  2001cited by this paper
• The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis

  2001cited by this paper
• Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis.

  2000cited by this paper
• Steatohepatitis: a tale of two "hits"?

  1998cited by this paper
• Effect of short-chain fatty acids on the human colonic mucosa in vitro.

  1992cited by this paper
• Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship.

  1989cited by this paper
• The fermentation pathways of Escherichia coli.

  1989cited by this paper
• Biologics: Targets and Therapy Dovepress Gut Microbiota: next Frontier in Understanding Human Health and Development of Biotherapeutics

  year unknowncited by this paper

• Christensenella intestinihominis MNO-863 improve obesity and related metabolic disorders via SCFAs-induced GLP-1 hormone secretion

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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
• Composition of gut microbiota and its correlations with neurological, intestinal, cardiovascular and metabolic diseases.

  2023cites this paper
• Causal Associations between Gut Microbiota and Different Types of Dyslipidemia: A Two-Sample Mendelian Randomization Study

  2023cites this paper
• Tartary Buckwheat Flavonoids Relieve Non-alcoholic Fatty Liver Disease by Inhibiting Lipid Accumulation, Inflammation, and Regulating Intestinal Flora

  2023cites this paper
• Novel Insight into the Mechanisms of Neurotoxicity Induced by 6:6 PFPiA through Disturbing the Gut-Brain Axis.

  2023cites this paper
• Oxidative Stress in Non-Alcoholic Fatty Liver Disease

  2022cites this paper
• Lessons on Drug Development: A Literature Review of Challenges Faced in Nonalcoholic Fatty Liver Disease (NAFLD) Clinical Trials

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Glucagon-like peptide 1 and fibroblast growth factor-21 in non-alcoholic steatohepatitis: An experimental to clinical perspective.

  2022cites this paper
• Effect of Hesperidin Supplementation on Liver Metabolomics and Gut Microbiota in a High-Fat Diet-Induced NAFLD Mice Model.

  2022cites this paper
• Insights from shotgun metagenomics into bacterial species and metabolic pathways associated with NAFLD in obese youth

  2022influential citation
• Early intervention with probiotics and metformin alleviates liver injury in NAFLD rats via targeting gut microbiota dysbiosis and p-AKT/mTOR/LC-3II pathways

  2021cites this paper
• Multi-donor Fecal Microbial Transplantation for Critically Ill Patients: Rationale and Standard Operating Procedure

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis

  2021influential citation
• Serum anandamide level as a potential indicator for nonalcoholic fatty liver disease severity

  2021cites this paper
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  2021cites this paper
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  2020cites this paper
• Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

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  2020cites this paper
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  2020cites this paper
• Black tea benefits short-chain fatty acid producers but inhibits genus Lactobacillus in the gut of healthy Sprague-Dawley rats.

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  2020cites this paper
• Sagittaria sagittifolia polysaccharide interferes with arachidonic acid metabolism in non-alcoholic fatty liver disease mice via Nrf2/HO-1 signaling pathway.

  2020cites this paper
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  2020cites this paper
• Lipid-lowering therapy in selected specific groups of patients

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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• Sodium Propionate and Sodium Butyrate Promote Fatty Acid Oxidation in HepG2 Cells under Oxidative Stress

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• Bacterial species and total bacterial load in the distal oesophagus in patients with and without clinical gastric reflux

  2019cites this paper
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  2019cites this paper
• The role of IFN in the development of NAFLD and NASH.

  2019cites this paper
• Study of the Inflammatory and Fibrotic Pathology in the Gut Following Microcystin Exposure Under Conditions of Non-Alcoholic Fatty Liver Disease.

  2019cites this paper
• Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients

  2018cites this paper
• Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease

  2018cites this paper
• Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction.

  2018cites this paper
• Underlying metabolic processes behind non-alcoholic fatty liver disease in population with metabolic syndrome features: Nutritional status and non-invasive liver tools

  2018cites this paper
• Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

  2018cites this paper
• Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression

  2018cites this paper
• Influence of hepatic steatosis on the outcomes of patients with chronic hepatitis B treated with entecavir and tenofovir

  2018cites this paper
• Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial

  2018cites this paper
• Periodontitis causes abnormalities in the liver of rats

  2018cites this paper
• Gut adaptation after metabolic surgery and its influences on the brain, liver and cancer

  2018cites this paper
• Fatty Liver Disease and Gut Microbiota: A Comprehensive Update

  2018influential citation
• Functional and comparative studies of members of the genus Methanosphaera, and their adaptations to the gut environment

  2017cites this paper
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  2017cites this paper
• Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia

  2017cites this paper
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  2017cites this paper
• A Study Of Hepatic Purinergic Receptor X7 Molecular Mechanisms In Ectopic Intestinal Inflammation In Environmental NAFLD

  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Gut microbiota and non-alcoholic fatty liver disease

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy

  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016influential citation
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  2016cites this paper
• Non-alcoholic fatty liver disease and dyslipidemia: An update.

  2016cites this paper
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  2016cites this paper
• Human Microbiome and its Association With Health and Diseases

  2016cites this paper
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  2016cites this paper
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