The unique DEK oncoprotein in women's health: A potential novel biomarker.

Breast and cervical cancer are the first and fourth cancer types with the highest prevalence in women, respectively. The developmental profiles of cancer in women can vary by genetic markers and cellular events. In turn, age and lifestyle influence in the cellular response and also on the cancer progression and relapse. The human DEK protein, a histone chaperone, belongs to a specific subclass of chromatin topology modulators, being involved in the regulation of DNA-dependent processes. These epigenetic mechanisms have dynamic and reversible nature, have been proposed as targets for different treatment approaches, especially in tumor therapy. The expression patterns of DEK vary between healthy and cancer cells. High expression of DEK is associated with poor prognosis in many cancer types, suggesting that DEK takes part in oncogenic activities via different molecular pathways, including inhibition of senescence and apoptosis. The focus of this review was to highlight the role of the DEK protein in these two female cancers.

• Publication year

  2018

• Venue

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

• Publication date

  2018-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.biopha.2018.06.082PMID 29957464
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human papillomavirus and cervical cancer

  2019cited by this paper
• The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer

  2018cited by this paper
• Roles of DEK in the endometrium of mice in early pregnancy.

  2018cited by this paper
• DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer

  2017cited by this paper
• Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case–Control Study of Patients with Head and Neck Squamous Cell Carcinoma

  2017cited by this paper
• DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

  2017cited by this paper
• Prognostic role of DEK in human solid tumors: a meta-analysis

  2017cited by this paper
• Occupational exposure and risk of breast cancer (Review)

  2016cited by this paper
• DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics

  2016cited by this paper
• Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer.

  2016cited by this paper
• The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners

  2016cited by this paper
• Effects of the lifestyle habits in breast cancer transcriptional regulation

  2016cited by this paper
• Metabolic control of epigenetics in cancer

  2016cited by this paper
• Human papillomavirus-associated cancers: A growing global problem

  2016cited by this paper
• Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer

  2016cited by this paper
• Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds.

  2016cited by this paper
• Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential.

  2016cited by this paper
• Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix

  2016cited by this paper
• Occupational exposure and risk of breast cancer.

  2016cited by this paper
• Overexpression of DEK gene is correlated with poor prognosis in hepatocellular carcinoma.

  2015cited by this paper
• Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer

  2015cited by this paper
• Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

  2015cited by this paper
• DEK over-expression promotes mitotic defects and micronucleus formation

  2015cited by this paper
• MicroRNA-592 targets DEK oncogene and suppresses cell growth in the hepatocellular carcinoma cell line HepG2.

  2015cited by this paper
• Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

  2015cited by this paper
• Mechanisms Underlying Cancer Growth and Apoptosis by DEK Overexpression in Colorectal Cancer

  2014cited by this paper
• High expression of DEK predicts poor prognosis of gastric adenocarcinoma

  2014cited by this paper
• High expression of oncoprotein DEK predicts poor prognosis of small cell lung cancer.

  2014cited by this paper
• The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress

  2014cited by this paper
• The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation

  2014cited by this paper
• The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity

  2014cited by this paper
• DEK promotes HPV positive and negative head and neck cancer cell proliferation

  2014cited by this paper
• The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor positive breast cancers

  2014cited by this paper
• The role of DEK protein in hepatocellular carcinoma for progression and prognosis

  2013cited by this paper
• Histone chaperones in nucleosome assembly and human disease

  2013cited by this paper
• DEK over expression as an independent biomarker for poor prognosis in colorectal cancer

  2013cited by this paper
• Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRASG12D-driven lung tumors

  2013cited by this paper
• Maintenance of muscle stem cell quiescence by microRNA-489

  2012cited by this paper
• Genomic occupancy of the transcriptional co-activators p300 and CBP

  2012cited by this paper
• Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.

  2012cited by this paper
• The DEK Oncogene Is a Target of Steroid Hormone Receptor Signaling in Breast Cancer

  2012cited by this paper
• Future directions and treatment strategies for head and neck squamous cell carcinomas.

  2012cited by this paper
• DEK overexpression is correlated with the clinical features of breast cancer

  2012cited by this paper
• Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer

  2011cited by this paper
• Histone chaperones: modulators of chromatin marks.

  2011cited by this paper
• The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.

  2011cited by this paper
• The human DEK oncogene stimulates beta catenin signaling, invasion and mammosphere formation in breast cancer

  2011cited by this paper
• DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung

  2010cited by this paper
• DNA methylation: a form of epigenetic control of gene expression

  2010cited by this paper
• A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.

  2010cited by this paper
• Melanoma proliferation and chemoresistance controlled by the DEK oncogene.

  2009cited by this paper
• Clinicopathological significance of DEK overexpression in serous ovarian tumors

  2009cited by this paper
• DEK proto-oncogene expression interferes with the normal epithelial differentiation program.

  2009cited by this paper
• Caspase‐dependent apoptosis induction by targeted expression of DEK in drosophila involves histone acetylation inhibition

  2008cited by this paper
• DEK overexpression in uterine cervical cancers

  2008cited by this paper
• Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status

  2007cited by this paper
• SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery

  2007cited by this paper
• Human papillomavirus and cervical cancer.

  2007cited by this paper
• Regulation of histone acetyltransferase activity of p300 and PCAF by proto‐oncogene protein DEK

  2006cited by this paper
• DEK Expression is Controlled by E2F and Deregulated in Diverse Tumor Type

  2006cited by this paper
• Intron Removal Requires Proofreading of U2AF/3' Splice Site Recognition by DEK

  2006cited by this paper
• Epigenetics and human disease: translating basic biology into clinical applications

  2006cited by this paper
• Apoptosis Inhibition by the Human DEK Oncoprotein Involves Interference with p53 Functions

  2006cited by this paper
• DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification

  2005cited by this paper
• The Human DEK Proto-Oncogene Is a Senescence Inhibitor and an Upregulated Target of High-Risk Human Papillomavirus E7

  2005cited by this paper
• The SAF-box domain of chromatin protein DEK

  2005cited by this paper
• p300/CBP-associated Factor Drives DEK into Interchromatin Granule Clusters*

  2005cited by this paper
• Functional Domains of the Ubiquitous Chromatin Protein DEK

  2004cited by this paper
• Phosphorylation by Protein Kinase CK2 Changes the DNA Binding Properties of the Human Chromatin Protein DEK

  2004cited by this paper
• The ‘PINIT’ motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L

  2003cited by this paper
• Structure-specific binding of the proto-oncogene protein DEK to DNA.

  2003cited by this paper
• The Ubiquitous Chromatin Protein DEK Alters the Structure of DNA by Introducing Positive Supercoils*

  2002cited by this paper
• Subcellular Localization of the Human Proto-oncogene Protein DEK*

  2001cited by this paper
• The identification of novel therapeutic targets for the treatment of malignant brain tumors.

  2000cited by this paper
• The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner.

  2000cited by this paper
• SAP - a putative DNA-binding motif involved in chromosomal organization.

  2000cited by this paper
• Autoantibodies to DEK oncoprotein in systemic lupus erythematosus (SLE)

  2000cited by this paper
• Autoantibodies to DEK oncoprotein in human inflammatory disease.

  2000cited by this paper
• Identification and characterization of genes associated with human hepatocellular carcinogenesis.

  1999cited by this paper
• Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

  1999cited by this paper
• Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

  1999cited by this paper
• Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis.

  1998cited by this paper
• Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

  1998cited by this paper
• Human papillomaviruses.

  1994cited by this paper
• The putative oncoprotein DEK, part of a chimera protein associated with acute myeloid leukaemia, is an autoantigen in juvenile rheumatoid arthritis

  1993cited by this paper
• The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA

  1992cited by this paper
• A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.

  1989cited by this paper
• The Application of Clinical Genetics Dovepress Inherited and Acquired Alterations in Development of Breast Cancer

  year unknowncited by this paper
• Copyright © American Society for Investigative Pathology Gene Discovery in Bladder Cancer Progression using cDNA Microarrays

  year unknowncited by this paper

• Mechanistic insights into RAD51-mediated nucleosome binding and remodeling in homologous recombination.

  2025cites this paper
• Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin

  2025cites this paper
• DEK-rRNA interactions regulate ribosome biogenesis and stress response

  2024cites this paper
• Imaging-based study demonstrates how the DEK nanoscale distribution differentially correlates with epigenetic marks in a breast cancer model

  2023cites this paper
• Super-resolution microscopy reveals the nanoscale organization of the DEK protein cancer biomarker

  2023cites this paper
• Super-resolution microscopy reveals the nanoscale cluster architecture of the DEK protein cancer biomarker

  2023cites this paper
• Role of DEK in carcinogenesis, diagnosis, prognosis, and therapeutic outcome of breast cancer: An evidence-based clinical review.

  2022cites this paper
• DEK domain-containing proteins control flowering time in Arabidopsis.

  2021cites this paper
• The silencing of DEK reduced disease resistance against Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 based on virus-induced gene silencing analysis in tomato.

  2019cites this paper
• 血清多肽组学作为Ⅰ期-Ⅱb期非小细胞肺癌标志物的初步研究

  2019cites this paper