Selectively Guanidinylated Aminoglycosides as Antibiotics

No abstract is available for this paper.

• Publication year

  2012

• Venue

  ChemMedChem

• Publication date

  2012-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/cmdc.201200150PMID 22639134PMCID PMC3383777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recent advances in developing small molecules targeting RNA.

  2012cited by this paper
• Antibiotics that target protein synthesis

  2011cited by this paper
• Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond.

  2011cited by this paper
• Global spread of drug-resistant Acinetobacter baumannii: molecular epidemiology and management of antimicrobial resistance.

  2011cited by this paper
• Unnecessary use of fluoroquinolone antibiotics in hospitalized patients

  2011cited by this paper
• Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates.

  2011cited by this paper
• Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues

  2011cited by this paper
• Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains.

  2011cited by this paper
• New treatment options for infections caused by multiresistant strains of Pseudomonas aeruginosa and other nonfermenting gram-negative bacilli.

  2011cited by this paper
• Designed Spiro‐Bicyclic Analogues Targeting the Ribosomal Decoding Center

  2011cited by this paper
• Linezolid, the first oxazolidinone antibacterial agent

  2011cited by this paper
• Cooperative, Heparan Sulfate‐Dependent Cellular Uptake of Dimeric Guanidinoglycosides

  2010cited by this paper
• Development of aminoglycoside antibiotics effective against resistant bacterial strains.

  2010cited by this paper
• Discovery of novel antibacterials

  2010cited by this paper
• Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents.

  2010cited by this paper
• Modulators of multidrug resistance associated proteins in the management of anticancer and antimicrobial drug resistance and the treatment of inflammatory diseases.

  2010cited by this paper
• Aminoglycosides redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases.

  2010cited by this paper
• Structure-based design of highly crowded ribostamycin/kanamycin hybrids as a new family of antibiotics.

  2010cited by this paper
• Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.

  2010cited by this paper
• Modulators of Multidrug Resistance Proteins in the Management of Anticancer and Antimicrobial Drug Resistance and the Treatment of Inflammatory Diseases

  2010cited by this paper
• The discovery of antibacterial agents using diversity-oriented synthesis.

  2009cited by this paper
• FRET enabled real time detection of RNA-small molecule binding.

  2009cited by this paper
• Pseudomonas aeruginosa - a phenomenon of bacterial resistance.

  2009cited by this paper
• Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics.

  2009cited by this paper
• Potential of old-generation antibiotics to address current need for new antibiotics

  2008cited by this paper
• New insights into aminoglycoside antibiotics and derivatives.

  2007cited by this paper
• Natural products as sources of new drugs over the last 25 years.

  2007cited by this paper
• Drugs for bad bugs: confronting the challenges of antibacterial discovery

  2007cited by this paper
• Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens.

  2006cited by this paper
• Heteroresistance to Colistin in Multidrug-Resistant Acinetobacter baumannii

  2006cited by this paper
• Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the γ-amino-α-hydroxybutyryl (haba) group

  2006cited by this paper
• Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group.

  2006cited by this paper
• A Tale of Two Targets: Differential RNA Selectivity of Nucleobase–Aminoglycoside Conjugates

  2006cited by this paper
• Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

  2006cited by this paper
• The ribosomal A-site as an inspiration for the design of RNA binders.

  2006cited by this paper
• Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

  2005cited by this paper
• Conformational constraint as a means for understanding RNA-aminoglycoside specificity.

  2005cited by this paper
• Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex.

  2005cited by this paper
• RNA as a target for small-molecule therapeutics

  2005cited by this paper
• Molecular recognition of RNA by neomycin and a restricted neomycin derivative.

  2005cited by this paper
• Appropriate antibiotic treatment of genitourinary infections in hospitalized patients.

  2005cited by this paper
• Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives.

  2005cited by this paper
• Versatility of Aminoglycosides and Prospects for Their Future

  2003cited by this paper
• Natural products as sources of new drugs over the period 1981-2002.

  2003cited by this paper
• Targeting RNA with Small Molecules

  2003cited by this paper
• Design of novel antibiotics that bind to the ribosomal acyltransfer site.

  2002cited by this paper
• Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site.

  2002cited by this paper
• The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition

  2002cited by this paper
• Preparation and use of N, N'-di-BOC-n -triflylguanidine: (Carbamic acid, [[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, bis(1,1-dimethylethyl) ester)

  2002cited by this paper
• Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit

  2001cited by this paper
• Riddle of Biofilm Resistance

  2001cited by this paper
• Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site.

  2001cited by this paper
• Overcoming antimicrobial resistance by targeting resistance mechanisms

  2001cited by this paper
• Performance standards for antimicrobial susceptibility testing

  2001cited by this paper
• Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

  2000cited by this paper
• Enhanced RNA binding of dimerized aminoglycosides.

  1999cited by this paper
• The aminoglycosides.

  1999cited by this paper
• Aminoglycosides: Activity and Resistance

  1999cited by this paper
• Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme.

  1998cited by this paper
• Designing Novel RNA Binders

  1998cited by this paper
• RNA–Aminoglycoside Interactions: Design, Synthesis, and Binding of “Amino‐aminoglycosides” to RNA

  1998cited by this paper
• RNA-Aminoglycosid-Wechselwirkungen: Design und Synthese von „Amino-aminoglycosiden” und deren Bindung an RNA

  1998cited by this paper
• Electrostatic Interactions in RNA Aminoglycosides Binding

  1997cited by this paper
• DIMERIC AMINOGLYCOSIDES: DESIGN, SYNTHESIS AND RNA BINDING

  1997cited by this paper
• Interaction of antibiotics with functional sites in 16S ribosomal RNA

  1987cited by this paper
• Misreading of ribonucleic acid code words induced by aminoglycoside antibiotics. The effect of drug concentration.

  1968cited by this paper
• Misreading of RNA codewords induced by aminoglycoside antibiotics.

  1965cited by this paper
• The Identity of Neomycin A,1Neamine2and the Methanolysis Product of Neomycin B and C3

  1952cited by this paper

• An innovative strategy to treat pathogenic biofilm-associated infections in vitro and in vivo using guanidinium-linked neomycin lipidation.

  2025cites this paper
• Guanidine dicycloamine-based analogs: green chemistry synthesis, biological investigation, and molecular docking studies as promising antibacterial and antiglycation leads

  2024cites this paper
• Conjugates of Aminoglycosides with Stapled Peptides as a Way to Target Antibiotic-Resistant Bacteria

  2023cites this paper
• Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa.

  2023cites this paper
• Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria

  2022cites this paper
• Antimicrobial drugs bearing guanidine moieties: A review.

  2021cites this paper
• Bicarbonate modulates delafloxacin activity against MDR Staphylococcus aureus and Pseudomonas aeruginosa.

  2021cites this paper
• Evaluation of 1H-Triazole-1-[N,N'-Bis(tert-butoxycarbonyl)]carboxamidine in Solution-Phase and On-Resin Guanidinylation.

  2021cites this paper
• Recent progresses in aminoglycoside conjugation for RNA targeting: antimicrobials and beyond.

  2020cites this paper
• A comparative QSAR analysis, 3D-QSAR, molecular docking and molecular design of iminoguanidine-based inhibitors of HemO: A rational approach to antibacterial drug design

  2020cites this paper
• Frameworks for targeting RNA with small molecules

  2020cites this paper
• Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster.

  2020cites this paper
• Polydopamine -aminoglycoside nanoconjugates: Synthesis, characterization, antimicrobial evaluation and cytocompatibility.

  2020cites this paper
• Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.

  2019cites this paper
• Enhanced topical delivery of non‐complexed molecular iodine for Methicillin‐resistant Staphylococcus aureus decolonization

  2019cites this paper
• Avibactam Sensitizes Carbapenem-Resistant NDM-1–Producing Klebsiella pneumoniae to Innate Immune Clearance

  2019cites this paper
• Bishydrazone-Based Antifungal Agents

  2019cites this paper
• Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens

  2019cites this paper
• Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors

  2018cites this paper
• Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device

  2018cites this paper
• DISCOVERY OF NEW ANTIMICROBIAL OPTIONS AND EVALUATION OF AMINOGLYCOSIDE RESISTANCE ENZYME-ASSOCIATED RESISTANCE EPIDEMIC

  2018cites this paper
• Awareness of dairy farmers about antibiotic resistance in Eastern Haryana region

  2018cites this paper
• Synthesis of hyaluronan-amikacin conjugate and its bactericidal activity against intracellular bacteria in vitro and in vivo.

  2018cites this paper
• How kanamycin A interacts with bacterial and mammalian mimetic membranes.

  2017cites this paper
• Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance.

  2017cites this paper
• Evaluation of Aminoglycoside and Carbapenem Resistance in a Collection of Drug-Resistant Pseudomonas aeruginosa Clinical Isolates

  2017cites this paper
• Guanidine Cellulose for Biocompatible Nanoparticles Phase Transfer

  2017cites this paper
• Amphipathic guanidine-embedded glyoxamide-based peptidomimetics as novel antibacterial agents and biofilm disruptors.

  2017cites this paper
• The chemistry and biology of guanidine natural products.

  2017cites this paper
• Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.

  2017cites this paper
• Pteridine Derivatives Modified with a Guanidine for Binding and Sensing an Orphan Guanine in RNA Duplexes

  2016cites this paper
• Selective modification of the 3''-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains.

  2016cites this paper
• Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa.

  2016cites this paper
• Neomycin B-cyclen conjugates and their Zn(II) complexes as RNA-binding agents.

  2016cites this paper
• Exploring Antibiotic and Innate Immune Synergies to Treat Multi-Drug Resistant Bacterial Infections

  2016cites this paper
• Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure-Activity Relationship Studies on New Aminoglycoside Conjugates.

  2016cites this paper
• Tobramycin Variants with Enhanced Ribosome‐Targeting Activity

  2015cites this paper
• Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting.

  2015cites this paper
• Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

  2015cites this paper
• Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D).

  2015cites this paper
• In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues.

  2014cites this paper
• New trends in aminoglycosides use.

  2014cites this paper
• Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A‐Site Binding and Higher Potency against Resistant Bacteria

  2014cites this paper
• Indium-mediated allylation in carbohydrate synthesis: A short and efficient approach towards higher 2-acetamido-2-deoxy sugars

  2014cites this paper
• New trends in the use of aminoglycosides

  2014cites this paper
• Polymyxins and Analogues Bind to Ribosomal RNA and Interfere with Eukaryotic Translation in Vitro

  2013cites this paper
• Special Challenges to the Rational Design of Antibacterial Agents

  2013cites this paper
• CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.

  2013cites this paper
• Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections.

  2013cites this paper