Mouse Genetics/Genomics: An Effective Approach for Drug Target Discovery and Validation

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Medicinal research reviews (Print)

• Publication date

  2000-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/(SICI)1098-1128(200005)20:3<216::AID-MED6>3.0.CO;2-0PMID 10797467
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse Chromosome 7

  1999cited by this paper
• Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

  1999cited by this paper
• Rapid modification of bacterial artificial chromosomes by ET-recombination.

  1999cited by this paper
• Mapping complex traits with single nucleotide polymorphisms

  1999cited by this paper
• Mapping a gene for combined hyperlipidaemia in a mutant mouse strain

  1998cited by this paper
• Alopecia universalis associated with a mutation in the human hairless gene.

  1998cited by this paper
• Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.

  1998cited by this paper
• Genetics of quantitative and qualitative aspects of lung tumorigenesis in the mouse: multiple interacting Susceptibility to lung cancer (Sluc) genes with large effects.

  1998cited by this paper
• Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

  1998cited by this paper
• Experimental strategies for the genetic dissection of complex traits in animal models

  1998cited by this paper
• Generation of radiation-induced deletion complexes in the mouse genome using embryonic stem cells.

  1997cited by this paper
• Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

  1997cited by this paper
• Mouse models of human disease. Part II: recent progress and future directions.

  1997cited by this paper
• Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

  1997cited by this paper
• Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome.

  1997cited by this paper
• Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.

  1997cited by this paper
• Zooming in on the human-mouse comparative map: genome conservation re-examined on a high-resolution scale.

  1997cited by this paper
• Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice.

  1997cited by this paper
• Induced mouse chromosomal rearrangements as tools for identifying critical developmental genes and pathways.

  1997cited by this paper
• Combining mutagenesis and genomics in the mouse--closing the phenotype gap.

  1996cited by this paper
• A candidate gene for the mouse mutation tubby

  1996cited by this paper
• Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype.

  1996cited by this paper
• Sensitivity to dietary obesity linked to a locus on Chromosome 15 in a CAST/Ei × C57BL/6J F2 intercross

  1996cited by this paper
• Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

  1995cited by this paper
• Positional cloning of the mouse obese gene and its human homologue

  1995cited by this paper
• Identification and expression cloning of a leptin receptor, OB-R.

  1995cited by this paper
• Taking stock of complex trait genetics in mice.

  1995cited by this paper
• Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.

  1995cited by this paper
• The agouti gene: turned on to yellow.

  1994cited by this paper
• Genetic animal models of alcohol and drug abuse.

  1994cited by this paper
• Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.

  1994cited by this paper
• Positional cloning of the mouse obese gene and its human homologue

  1994cited by this paper
• Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

  1994cited by this paper
• A genetic linkage map of the mouse: current applications and future prospects.

  1993cited by this paper
• The Genetic Basis of Common Diseases

  1993cited by this paper
• Molecular characterization of the mouse agouti locus.

  1992cited by this paper
• Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

  1989cited by this paper
• Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.

  1979cited by this paper
• Biology of the Laboratory Mouse

  1957cited by this paper
• Radiation Genetics

  1951cited by this paper

• Delivery of microbial metabolites for human health care: a review

  2020cites this paper
• Bioactive Metabolites Isolated from Microorganisms for Healthcare: Types and Delivery Routes

  2019cites this paper
• Natural products: a hope for glioblastoma patients

  2018cites this paper
• High-Throughput Automated Chemical Screens in Zebrafish.

  2018cites this paper
• C. elegans screening strategies to identify pro-longevity interventions.

  2016cites this paper
• Novel Gluconeogenesis Regulators for Anti-diabetic Drug Repurposing using Transgenic Zebrafish pck1 Reporters

  2015cites this paper
• Behavioral studies on anxiety and depression in a drug discovery environment: keys to a successful future.

  2015cites this paper
• Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products

  2015cites this paper
• Animal models of invasive aspergillosis for drug discovery.

  2014cites this paper
• Bioactive molecules: current trends in discovery, synthesis, delivery and testing

  2013cites this paper
• Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder.

  2013cites this paper
• Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression

  2012cites this paper
• Effect of successive extracts of Stachys tibetica Vatke (Lamiaceae) in anxiety

  2012cites this paper
• Anti-anxiety activity of successive extracts of Angelica archangelica Linn. on the elevated T-maze and forced swimming tests in rats.

  2012cites this paper
• Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol.

  2011cites this paper
• High‐throughput screening and small animal models, where are we?

  2010cites this paper
• C. elegans, un outil de criblage pour la recherche de traitements contre les maladies rares

  2010cites this paper
• AVALIAÇÃO DE PADRÕES COMPORTAMENTAIS INDUZIDOS POR ANSIOLÍTICOS EM ZEBRAFISH (Danio rerio)

  2010cites this paper
• Significance of the zebrafish model in the discovery of bioactive molecules from nature

  2009cites this paper
• Behavioral and Brain Functions

  2009cites this paper
• Fine mapping of trypanosomosis resistance loci in murine by haplotype approach.

  2008cites this paper
• Genomic DNA Damage in Mouse Transgenesis1

  2007cites this paper
• 2.12 – How and Why to Apply the Latest Technology*

  2007cites this paper
• Introduction Strategies in Drug Discovery and Evaluation

  2007cites this paper
• Small inhibitory RNA--a tool for credentialing candidate genes.

  2005cites this paper
• Pharmacogenomics and the Drug Discovery Pipeline

  2005cites this paper
• Pharmacogenomics and the drug discovery pipeline: when should it be implemented?

  2005cites this paper
• Genotype identification of Math1/LacZ knockout mice based on real-time PCR with SYBR Green I dye.

  2004cites this paper
• Use of new biotechnology to design rational drugs against newly defined targets.

  2004cites this paper
• The Making of “Transgenic Spermatozoa”1

  2003cites this paper
• Exposing oncogenic dependencies for cancer drug target discovery and validation using RNAi.

  2003cites this paper
• A Commentary on Issue Articles by Metzger, Schutte, Maas, Buckwalter, Wung, and Aouizerat

  2003cites this paper
• The use of animal models in cancer research

  2002cites this paper
• Expression of the genes for arylamine N-acetyltransferases in mice

  2002cites this paper
• Recent advances in molecular genetics of breast cancer

  2001cites this paper
• Use of isogenic human cancer cells for high-throughput screening and drug discovery

  2001cites this paper
• The human genome project: a historical perspective.

  2001cites this paper
• Murine inter-strain polymorphisms alter gene targeting frequencies at the mu opioid receptor locus in embryonic stem cells

  2001cites this paper
• KO's and organisation of peptidergic feeding behavior mechanisms.

  2001cites this paper
• Current Awareness on Comparative and Functional Genomics

  2000cites this paper