The Bioactive Lipid 4-Hydroxyphenyl Retinamide Inhibits Flavivirus Replication

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2014-10-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/AAC.04177-14PMID 25313218PMCID PMC4291433
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

  2014cited by this paper
• Japanese Encephalitis Virus

  2014cited by this paper
• Requirement of cholesterol in the viral envelope for dengue virus infection.

  2013cited by this paper
• INVESTIGATION OF ORAL FENRETINIDE FOR TREATMENT OF GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION

  2013cited by this paper
• The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase

  2013influential reference
• Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.

  2013cited by this paper
• Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection

  2013cited by this paper
• Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA.

  2013cited by this paper
• Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

  2013influential reference
• The global distribution and burden of dengue

  2013cited by this paper
• NIH Image to ImageJ: 25 years of image analysis

  2012cited by this paper
• Identification of a Novel Antiviral Inhibitor of the Flavivirus Guanylyltransferase Enzyme

  2012cited by this paper
• Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo

  2012cited by this paper
• Lipids at the interface of virus-host interactions.

  2012cited by this paper
• Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus.

  2012cited by this paper
• Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.

  2012cited by this paper
• Small-Molecule Inhibitors of Dengue-Virus Entry

  2012cited by this paper
• Mutagenesis of the DI/DIII Linker in Dengue Virus Envelope Protein Impairs Viral Particle Assembly

  2012cited by this paper
• Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells

  2012cited by this paper
• Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.

  2011cited by this paper
• Immune response to dengue virus and prospects for a vaccine.

  2011cited by this paper
• Inhibition of Dengue Virus by Targeting Viral NS4B Protein

  2011influential reference
• Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure

  2011cited by this paper
• Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 activity.

  2011cited by this paper
• Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication*

  2011cited by this paper
• Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide*

  2011influential reference
• Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.

  2011cited by this paper
• A Non Mouse-Adapted Dengue Virus Strain as a New Model of Severe Dengue Infection in AG129 Mice

  2010cited by this paper
• Interplay of RNA Elements in the Dengue Virus 5′ and 3′ Ends Required for Viral RNA Replication

  2010cited by this paper
• Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

  2010cited by this paper
• Involvement of Ceramide in the Propagation of Japanese Encephalitis Virus

  2010cited by this paper
• Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific Lipids

  2010cited by this paper
• Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling.

  2009cited by this paper
• Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis.

  2009cited by this paper
• Adaptation of the hepatitis C virus to cell culture.

  2009cited by this paper
• Measuring HCV infectivity produced in cell culture and in vivo.

  2009cited by this paper
• A small molecule fusion inhibitor of dengue virus.

  2009cited by this paper
• N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

  2008influential reference
• Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells

  2008cited by this paper
• The capsid-coding region hairpin element (cHP) is a critical determinant of dengue virus and West Nile virus RNA synthesis.

  2008cited by this paper
• Enhancement by Tumor Necrosis Factor Alpha of Dengue Virus-Induced Endothelial Cell Production of Reactive Nitrogen and Oxygen Species Is Key to Hemorrhage Development

  2008cited by this paper
• c-Src protein kinase inhibitors block assembly and maturation of dengue virus

  2007cited by this paper
• Characterization of the Early Events in Dengue Virus Cell Entry by Biochemical Assays and Single-Virus Tracking

  2007cited by this paper
• Improved Oral Delivery of N-(4-Hydroxyphenyl)Retinamide with a Novel LYM-X-SORB Organized Lipid Complex

  2007cited by this paper
• A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.

  2007cited by this paper
• Subcellular Localization and Membrane Topology of the Dengue Virus Type 2 Non-structural Protein 4B*

  2006cited by this paper
• Replication of a hepatitis C virus replicon clone in mouse cells

  2006cited by this paper
• Inhibition of dengue virus replication by mycophenolic acid and ribavirin.

  2006cited by this paper
• Fenretinide inhibits HIV infection by promoting viral endocytosis.

  2006cited by this paper
• Mechanisms of fenretinide-induced apoptosis

  2006cited by this paper
• Randomized trial of fenretinide (4‐HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: Long‐term results

  2005cited by this paper
• Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites.

  2003cited by this paper
• Analysis of ceramides in cosmetics by reversed-phase liquid chromatography/electrospray ionization mass spectrometry with collision-induced dissociation.

  2003cited by this paper
• Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA.

  2002cited by this paper
• Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis*

  2002influential reference
• N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

  2001cited by this paper
• Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma.

  2000cited by this paper
• Mass Spectrometric Identification of Increased C16 Ceramide Levels During Apoptosis*

  1999cited by this paper
• Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer.

  1999cited by this paper
• Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines.

  1999cited by this paper
• N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

  1998cited by this paper
• Nuclear localization of dengue 2 virus core protein detected with monoclonal antibodies.

  1992cited by this paper
• Visual and cutaneous toxicity which occurs during N‐(4‐hydroxyphenyl) retinamide therapy for psoriasis

  1986cited by this paper

• Dengue virus and lipid metabolism: unravelling the interplay for future therapeutic approaches

  2025cites this paper
• A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection

  2025cites this paper
• Tick-borne encephalitis virus modulates sphingolipid and phospholipid metabolism in infected human neuronal cells.

  2024cites this paper
• Machine learning and molecular docking prediction of potential inhibitors against dengue virus

  2024cites this paper
• Improving Retinoic Acid Efficacy: Lipase‐Catalyzed Synthesis of Derivatives with Antiviral Activity

  2024cites this paper
• Analysis and functions of bioactive lipids in food

  2024cites this paper
• Perspectives on the current antiviral developments towards RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) domains of dengue virus non-structural protein 5 (DENV-NS5).

  2023cites this paper
• Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus

  2023cites this paper
• Host Cell Targets for Unconventional Antivirals against RNA Viruses

  2023cites this paper
• Mosquito-Borne Flaviviruses and Current Therapeutic Advances

  2022influential citation
• Biologics for dengue prevention: up-to-date

  2022cites this paper
• A review on structural genomics approach applied for drug discovery against three vector-borne viral diseases: Dengue, Chikungunya and Zika

  2022cites this paper
• Murine models of dengue virus infection for novel drug discovery

  2022cites this paper
• Antivirals that target the host IMPα/β1-virus interface

  2021cites this paper
• Novel Antiviral Strategies Against Emerging Arbovirus Infections

  2021cites this paper
• Anti-flavivirus Properties of Lipid-Lowering Drugs

  2021cites this paper
• Ceramide and Related Molecules in Viral Infections

  2021cites this paper
• Antiviral Compounds for Blocking Arboviral Transmission in Mosquitoes

  2021cites this paper
• Interference of dengue replication by blocking the access of 3´ SL RNA to the viral RNA-dependent RNA polymerase.

  2020cites this paper
• A Wonder Drug in the Arsenal against COVID - 19: Medication Evidence from Ivermectin

  2020cites this paper
• Recent advances in antiviral drug development towards dengue virus.

  2020cites this paper
• The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model

  2020cites this paper
• Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment in COVID-19

  2020cites this paper
• Dengue drug discovery: Progress, challenges and outlook

  2019cites this paper
• Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti

  2019cites this paper
• Non-Structural Proteases as a Target of Dengue Virus

  2019cites this paper
• Characterization and structure‐activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

  2018cites this paper
• Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis

  2018cites this paper
• Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies.

  2018cites this paper
• Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes

  2018cites this paper
• Discovery of Dengue Virus Inhibitors.

  2018cites this paper
• Structure − Activity Relationship Study of QL 47 : A Broad-Spectrum Antiviral Agent

  2017cites this paper
• Indirect Acting Antivirals ; Tricking the Virus through a Pristine Approach

  2017cites this paper
• Involvement of fatty acid synthase in dengue virus infection

  2017cites this paper
• Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

  2017cites this paper
• Pharmacological intervention for dengue virus infection.

  2017cites this paper
• Antiviral activity of N‐(4‐hydroxyphenyl) retinamide (4‐HPR) against Zika virus

  2017cites this paper
• The Medicinal Chemistry of Dengue Virus.

  2016cites this paper
• Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses.

  2016influential citation
• Cracking the code of chikungunya virus : inhibitors as tools to explore alphavirus biology

  2016cites this paper
• Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor

  2016cites this paper
• Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy.

  2016cites this paper
• Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses.

  2016cites this paper
• GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein.

  2016cites this paper
• Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.

  2016cites this paper
• A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle

  2016cites this paper
• The quest for host targets to combat dengue virus infections.

  2016cites this paper
• Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.

  2016cites this paper
• Flaviviruses: Introduction to Dengue Viruses

  2015cites this paper
• Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus.

  2015cites this paper
• The dengue virus NS5 protein as a target for drug discovery.

  2015cites this paper
• Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication

  2015cites this paper