Removal of terminal alpha-galactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity but persistence of IgG1-mediated antibody-dependent cell-mediated cytotoxicity.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Transplantation

• Publication date

  1996-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/00007890-199607150-00020PMID 8693523
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

  1996cited by this paper
• Transient perturbation of endothelial integrity induced by natural antibodies and complement

  1995cited by this paper
• Biochemical studies of pig xenoantigens detected by naturally occurring human antibodies and the galactose alpha(1-3)galactose reactive lectin.

  1995cited by this paper
• Detection, immunoabsorption, and inhibition of cytotoxic activity of anti‐αGal antibodies using newly developed substances with synthetic Gal α1–3Gal disaccharide epitopes

  1995cited by this paper
• Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies.

  1995cited by this paper
• Inhibition of the human antipig xenograft reaction with soluble oligosaccharides.

  1995cited by this paper
• Evidence of noninvolvement of swine MHC class II in the in vitro proliferative response of human lymphocytes to porcine endothelial cells.

  1995cited by this paper
• Characterization of porcine endothelial cell determinants recognized by human natural antibodies

  1994cited by this paper
• Antibody-dependent cell-mediated cytotoxicity against porcine endothelium induced by a majority of human sera.

  1994cited by this paper
• Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

  1994cited by this paper
• PROTECTION OF PIG KIDNEY (PK15) CELLS FROM THE CYTOTOXIC EFFECT OF ANTI‐PIG ANTIBODIES BY α‐GALACTOSYL OLIGOSACCHARIDES1

  1994cited by this paper
• Effect of human inflammatory cytokines on porcine endothelial cell MHC molecule expression: unique role for TNF-alpha in MHC class-II induction.

  1994cited by this paper
• Oligosaccharides and Discordant Xenotransplantation

  1994cited by this paper
• Gal alpha(1,3)Gal is the major xenoepitope expressed on pig endothelial cells recognized by naturally occurring cytotoxic human antibodies.

  1994cited by this paper
• Early Events in Cell‐Mediated Recognition of Vascularized Xenografts: Cooperative Interactions between Selected Lymphocyte Subsets and Natural Antibodies

  1994cited by this paper
• Anti‐endothelial cell antibodies in sera of patients with autoimmune diseases: comparison between ELISA and FACS analysis

  1994cited by this paper
• Hyperacute xenograft rejection in the swine-to-human donor-recipient combination. In vitro analysis of complement activation.

  1994cited by this paper
• Human natural antibodies to porcine platelets.

  1994cited by this paper
• Characterization and affinity isolation of xenoreactive human natural antibodies.

  1994cited by this paper
• Serum IgG subclass level determination: methodological difficulties and practical aspects.

  1994cited by this paper
• Natural Antibodies and Human Xenotransplantation

  1994cited by this paper
• Enzymatic removal from various tissues of the galactose alpha 1,3-galactose target antigens of human antispecies antibodies.

  1994cited by this paper
• Intravenous administration of alpha-galactosyl carbohydrates reduces in vivo baboon serum cytotoxicity to pig kidney cells and transplanted pig hearts.

  1994cited by this paper
• Identification of Gal(α1,3)Gal as the major epitope for pig-to-human vascularised xenografts

  1994cited by this paper
• Variability of anti‐αGal antibodies in human serum and their relation to serum cytotoxicity against pig cells

  1994cited by this paper
• Cytolytic effect of human anti‐Gal IgM and complement on porcine endothelial cells: A kinetic analysis

  1994cited by this paper
• Human xenoreactive natural antibodies of the IgM isotype activate pig endothelial cells

  1994cited by this paper
• Cytotoxic effects of human preformed anti-Gal IgG and complement on cultured pig cells.

  1994cited by this paper
• Structural motifs involved in human IgG antibody effector functions

  1993cited by this paper
• Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

  1993cited by this paper
• Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.

  1993cited by this paper
• IL-4, but not tumor necrosis factor-alpha, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway.

  1993cited by this paper
• Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans.

  1993cited by this paper
• Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2.

  1993cited by this paper
• CARBOHYDRATE ANTIGENS OF PIG TISSUES REACTING WITH HUMAN NATURAL ANTIBODIES AS POTENTIAL TARGETS FOR HYPERACUTE VASCULAR REJECTION IN PIG‐TO‐MAN ORGAN XENOTRANSPLANTATION1

  1993cited by this paper
• Binding of monomeric human IgG defines an expression polymorphism of Fc gamma RIII on large granular lymphocyte/natural killer cells.

  1993cited by this paper
• REMOVAL OF NATURAL HUMAN XENOANTIBODIES TO PIG VASCULAR ENDOTHELIUM BY PERFUSION OF BLOOD THROUGH PIG KIDNEYS AND LIVERS

  1993cited by this paper
• Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor.

  1992cited by this paper
• Antibody dependent cell-mediated cytotoxicity induced by chimeric mouse-human IgG subclasses and IgG3 antibodies with altered hinge region.

  1992cited by this paper
• Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: results of an IUIS/WHO collaborative study.

  1992cited by this paper
• Evaluation of monoclonal antibodies having specificity for human IgG subclasses: results of the 2nd IUIS/WHO collaborative study.

  1992cited by this paper
• Carbohydrate specificity of human immunoglobulin-M antibodies with pig lymphocytotoxic activity.

  1992cited by this paper
• THE ROLE OF NATURAL ANTIBODIES IN THE ACTIVATION OF XENOGENIC ENDOTHELIAL CELLS

  1991cited by this paper
• Fc receptors.

  1991cited by this paper
• The barrier to xenotransplantation.

  1991cited by this paper
• POLYREACTIVITY AND ANTIGEN SPECIFICITY OF HUMAN XENOREACTIVE MONOCLONAL AND SERUM NATURAL ANTIBODIES

  1991cited by this paper
• Carbohydrates in the functions of natural killer cells.

  1991cited by this paper
• Naturally-occurring anti-alpha-galactosyl antibodies in human Plasmodium falciparum infections--a possible role for autoantibodies in malaria.

  1988cited by this paper
• Xenogeneic transplantation. A review.

  1988cited by this paper
• The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence.

  1987cited by this paper
• Isohemagglutinins and preformed natural antibodies in xenogeneic organ transplantation.

  1987cited by this paper
• Effect of weather on daily pain score in rheumatoid arthritis.

  1987cited by this paper
• IgG subclasses in bacterial infections.

  1986cited by this paper
• Mapping the functional topography of Fcγ with monoclonal antibodies: localization of epitopes interacting with the binding sites of Fc receptor on human K cells

  1985cited by this paper
• Preparation and characterization of monoclonal antibodies reactive with porcine PBL.

  1984cited by this paper
• Binding of simple carbohydrates and some N-acetyllactosamine-containing oligosaccharides to Erythrina cristagalli agglutinin as followed with a fluorescent indicator ligand.

  1984cited by this paper
• Two monoclonal anticarbohydrate antibodies directed to glycosphingolipids with a lacto-N-glycosyl type II chain.

  1981cited by this paper
• Carbohydrate binding studies on the Bandeiraea simplicifolia I isolectins. Lectins which are mono-, di-, tri-, and tetravalent for N-acetyl-D-galactosamine.

  1981cited by this paper
• Sugar-lectin interactions: how does wheat-germ agglutinin bind sialoglycoconjugates?

  1980cited by this paper
• Human lymphocytotoxic and haemagglutinating activity against sheep and pig cells.

  1968cited by this paper
• QUANTITATIVE STUDIES OF THE SENSITIVITY OF NORMAL AND NEOPLASTIC MOUSE CELLS TO THE CYTOTOXIC ACTION OF ISOANTIBODIES

  1962cited by this paper

• Statistical optimization and sequential scale-up of α-galactosidase production by Actinoplanes utahensis B1 from shake flask to pilot scale

  2024cites this paper
• Current Scenario and Future Perspectives of Porcine Corneal Xenotransplantation

  2024cites this paper
• Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

  2023cites this paper
• Effects of fishmeal substitution by α-galactosidase hydrolytic soybean meal (EhSBM) on growth, antioxidant capacity, inflammatory responses and intestinal health of turbot juveniles (Scophthalmus maximus L.)

  2022cites this paper
• Cardiac xenotransplantation: a promising way to treat advanced heart failure

  2020cites this paper
• Vaccine Therapy in Pancreatic Cancer

  2018cites this paper
• 16 – α-Galactosidases

  2017cites this paper
• The Role of NK Cells in Pig-to-Human Xenotransplantation

  2017cites this paper
• Current and Emerging Therapies in Pancreatic Cancer

  2017cites this paper
• Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

  2016cites this paper
• Cellular Immunotherapy Study of Prostate Cancer Patients and Resulting IgG Responses to Peptide Epitopes Predicted From Prostate Tumor-associated Autoantigens

  2013cites this paper
• Anticorps thérapeutiques et réactions à la perfusion : cas de l’anaphylaxie au cétuximab et facteurs prédictifs

  2013cites this paper
• This information is current as Direct Xenogeneic NK Cytotoxicity Prevents Complement-Induced Lysis but Not Expression on Porcine Endothelial Cells -1,3-Galactose α Lack of Galactose-

  2013cites this paper
• Chapter 29 – HyperAcute Vaccines: A Novel Cancer Immunotherapy

  2013cites this paper
• Transgenic pigs designed to express human α-galactosidase to avoid humoral xenograft rejection

  2013cites this paper
• Addition of Algenpantucel-L Immunotherapy to Standard Adjuvant Therapy for Pancreatic Cancer: a Phase 2 Study

  2012cites this paper
• Vascular Adhesion Molecules and Inflammation

  2012cites this paper
• Elimination of alpha-gal xenoreactive epitope: alpha-galactosidase treatment of porcine heart valves.

  2012cites this paper
• Substrate specificities and mechanism of action of multiple α-galactosidases from Streptomyces griseoloalbus

  2011cites this paper
• Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D

  2008cites this paper
• Gal Knockout and Beyond

  2007cites this paper
• Soluble Galα(1,3)Gal conjugate combined with hDAF preserves morphology and improves function of cardiac xenografts

  2007cites this paper
• Xenotransfusions, past and present

  2007cites this paper
• Reactivity of Human Natural Antibodies to Endothelial Cells From Gal&agr;(1,3)Gal-Deficient Pigs

  2007cites this paper
• Characterization and Ligand Interactions Nonhuman Primate Species : Genetic IgG Fc Receptor III Homologues in Attanasio

  2006cites this paper
• Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)

  2006cites this paper
• T‐cell responses during pig‐to‐primate xenotransplantation

  2006cites this paper
• IgG Fc Receptor III Homologues in Nonhuman Primate Species: Genetic Characterization and Ligand Interactions12

  2006cites this paper
• Immunoglobulins and Immunoglobulin Fc Receptors in Nonhuman Primates Commonly Used in Biomedical Research

  2006cites this paper
• Effective treatment of preexisting melanoma with whole cell vaccines expressing alpha(1,3)-galactosyl epitopes.

  2005cites this paper
• Reducing Gal expression on the pig organ – a retrospective review

  2005cites this paper
• Administration of GAS914 in an orthotopic pig‐to‐baboon heart transplantation model

  2005cites this paper
• Complete protection against melanoma in absence of autoimmune depigmentation after rejection of melanoma cells expressing α(1,3)galactosyl epitopes

  2005cites this paper
• α1,3‐Galactosyltransferase knockout pigs are available for xenotransplantation: Are glycosyltransferases still relevant?

  2005cites this paper
• Biological activity of pig islet‐cell reactive IgG antibodies in xenotransplanted diabetic patients

  2004cites this paper
• In-vitro-Modell eines xenogenen Systems: Chronische Wirkungen induzierter versus präformierter Antikörper auf Herzmuskelzellkulturen von neonatalen Ratten

  2004cites this paper
• Lack of Galactose-α-1,3-Galactose Expression on Porcine Endothelial Cells Prevents Complement-Induced Lysis but Not Direct Xenogeneic NK Cytotoxicity1

  2004cites this paper
• Human alpha galactosidase and alpha 1,2 fucosyltransferase concordantly inhibit xenoreactivity of NIH 3T3 cells with human serum.

  2003cites this paper
• Antibody-mediated activation of the classical complement pathway in xenograft rejection.

  2002cites this paper
• Reduction of alpha-galactosyl xenoantigen by expression of endo-beta-galactosidase C in pig endothelial cells.

  2002cites this paper
• Reduction of α‐galactosyl xenoantigen by expression of endo‐β‐galactosidase C in pig endothelial cells

  2002cites this paper
• Continued production of xenoimmune antibodies 6–8 years after clinical transplantation of fetal pig islet‐like cell‐clusters

  2001cites this paper
• Blocking of human anti-pig xenoantibodies by soluble GALα1–3GAL and Galα1–2GAL disaccharides; studies in a pig kidney in vitro perfusion model

  2000cites this paper
• The target antigens of naturally occurring human anti‐β‐galactose IgG are cryptic on porcine aortic endothelial cells

  2000cites this paper
• Blocking of human anti-pig xenoantibodies by soluble GAL alpha 1-3Gal and Gal alpha 1-2Gal disaccharides; studies in a pig kidney in vitro perfusion model.

  2000cites this paper
• Prospects for xenotransplantation.

  2000cites this paper
• Development of an ex vivo model of pig kidney perfused with human lymphocytes. Analysis of xenogeneic cellular reactions.

  2000cites this paper
• ALPHA-GAL-INDEPENDENT DUAL RECOGNITION AND ACTIVATION OF XENOGENEIC ENDOTHELIAL CELLS AND HUMAN NAÏVE NATURAL KILLER CELLS1

  2000cites this paper
• Molecular Cloning of Endo-β-galactosidase C and Its Application in Removing α-Galactosyl Xenoantigen from Blood Vessels in the Pig Kidney*

  2000cites this paper
• POTENTIAL USE OF GENETICALLY MODIFIED PIGS AS ORGAN DONORS FOR TRANSPLANTATION INTO HUMANS

  1999cites this paper
• A reliable, rapid and inexpensive two-color fluorescence assay to monitor serum cytotoxicity in xenotransplantation.

  1999cites this paper
• Physiologic incompatibilities in discordant xenotransplantation.

  1999cites this paper
• α-Gal and Anti-Gal

  1999cites this paper
• Target cell susceptibility to lysis by human natural killer cells is augmented by alpha(1,3)-galactosyltransferase and reduced by alpha(1, 2)-fucosyltransferase.

  1999cites this paper
• Factors in Xenograft Rejection

  1999cites this paper
• Comparative analysis of three genetic modifications designed to inhibit human serum‐mediated cytolysis

  1999cites this paper
• Pig xenogeneic antigen modification with green coffee bean α‐galactosidase

  1999cites this paper
• The Griffonia simplicifolia I-B4 isolectin. A probe for alpha-D-galactosyl end groups.

  1999cites this paper
• Characterization of human xenoreactive antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment: an ex vivo model of pig to human xenotransplantation.

  1999cites this paper
• Induction of swine major histocompatibility complex class I molecules on porcine endothelium by tumor necrosis factor-alpha reduces lysis by human natural killer cells.

  1999cites this paper
• Leukocyte adhesion and activation in xenografts

  1999cites this paper
• Target Cell Susceptibility to Lysis by Human Natural Killer Cells Is Augmented by α(1,3)-Galactosyltransferase and Reduced by α(1,2)-Fucosyltransferase*

  1999cites this paper
• Pig xenogeneic antigen modification with green coffee bean alpha-galactosidase.

  1999cites this paper
• Anti-Gal, alpha-Gal epitopes, and xenotransplantation.

  1999cites this paper
• Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type I activation.

  1998cites this paper
• Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type II activation.

  1998cites this paper
• Removal of primate xenoreactive natural antibodies by extracorporeal perfusion of pig kidneys and livers.

  1998cites this paper
• Xenogeneic transplantation.

  1998cites this paper
• Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period.

  1998cites this paper
• a-GALACTOSYL EPITOPE-MEDIATED ACTIVATION OF PORCINE AORTIC ENDOTHELIAL CELLS

  1998cites this paper
• Human preformed IgG combining with membrane‐bound porcine serotransferrin lyse porcine endothelial cells through antibody‐dependent cellular cytotoxicity

  1998cites this paper
• B-cell reconstitution and xenoreactive anti-pig natural antibody production in severe combined immunodeficient mice reconstituted with immunocompetent B cells from varying sources.

  1998cites this paper
• Xenotransplantation literature update

  1997cites this paper
• Involvement of complement components in renal disease

  1997cites this paper
• Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)Gal.

  1997cites this paper
• Immature Host for Xenotransplantation

  1997cites this paper
• Cardiac xenotransplantation.

  1997cites this paper
• Comparative study of target antigens for primate xenoreactive natural antibodies in pig and rat endothelial cells.

  1997cites this paper