Frequent loss of claudin‐4 expression in dedifferentiated and undifferentiated endometrial carcinomas

Dedifferentiated endometrial carcinomas (DDECs)/undifferentiated endometrial carcinomas (UECs) are aggressive endometrial cancers with frequent genomic inactivation of core components of switch/sucrose non‐fermentable (SWI/SNF) complex proteins. Claudin‐4, an epithelial intercellular tight junction protein, was recently found to be expressed in SWI/SNF‐deficient undifferentiated carcinomas but not in SWI/SNF‐deficient sarcomas. The aim of this study was to examine claudin‐4 expression in UECs/DDECs and other high‐grade uterine carcinomas.

• Publication year

  2018

• Venue

  Histopathology

• Publication date

  2018-05-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/his.13525PMID 29671892PMCID PMC6758559
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1neg/CK7pos/HepPar-1pos immunophenotype

  2017cited by this paper
• Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas

  2017cited by this paper
• SMARCA4-deficient Sinonasal Carcinoma

  2017cited by this paper
• Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response

  2017cited by this paper
• Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas

  2016influential reference
• Immunophenotypic features of dedifferentiated endometrial carcinoma – insights from BRG1/INI1‐deficient tumours

  2016cited by this paper
• Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas

  2016cited by this paper
• Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis

  2015cited by this paper
• Claudin-4 controls the proliferation, apoptosis, migration and in vivo growth of MCF-7 breast cancer cells.

  2015cited by this paper
• Claudin-4 expression in gastric cancer cells enhances the invasion and is associated with the increased level of matrix metalloproteinase-2 and -9 expression

  2014cited by this paper
• Vulnerabilities of mutant SWI/SNF complexes in cancer.

  2014cited by this paper
• Immunohistochemical Survey of Mismatch Repair Protein Expression in Uterine Sarcomas and Carcinosarcomas

  2014cited by this paper
• Molecular Characterization of Undifferentiated Carcinoma Associated With Endometrioid Carcinoma

  2014cited by this paper
• SMARCB1(INI1)-deficient Sinonasal Basaloid Carcinoma

  2014cited by this paper
• A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

  2013cited by this paper
• Distinct Claudin Expression Profiles of Hepatocellular Carcinoma and Metastatic Colorectal and Pancreatic Carcinomas

  2013cited by this paper
• Occludin is required for apoptosis when claudin–claudin interactions are disrupted

  2012cited by this paper
• Claudin Expression in High Grade Invasive Ductal Carcinoma of the Breast: Correlation with the Molecular Subtype

  2012cited by this paper
• Selective inhibition of BET bromodomains

  2010cited by this paper
• Increased claudin‐4 expression is associated with poor prognosis and high tumour grade in breast cancer

  2009cited by this paper
• Expression of claudin-3 and claudin-4 in normal, hyperplastic, and malignant endometrial tissue

  2006cited by this paper
• Undifferentiated Carcinoma of the Endometrium

  2005cited by this paper
• Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability.

  2001cited by this paper
• Cancer Management and Research Dovepress the Claudin Family of Proteins in Human Malignancy: a Clinical Perspective

  year unknowncited by this paper

• Distinct genomic subgroups and mutational patterns in undifferentiated/dedifferentiated endometrial carcinoma

  2025cites this paper
• Claudins in Cancer: A Current and Future Therapeutic Target

  2024cites this paper
• Uncommon and Difficult High-Grade Endometrial Carcinomas.

  2022cites this paper
• ZEB1 expression is frequently detected in undifferentiated and de‐differentiated carcinomas, but is not specific among endometrial carcinomas

  2022cites this paper
• The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.

  2022cites this paper
• The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma

  2021cites this paper
• Claudins: New Players in Human Fertility and Reproductive System Cancers

  2020cites this paper
• A Comprehensive Review of Biomarker Use in the Gynecologic Tract Including Differential Diagnoses and Diagnostic Pitfalls.

  2020cites this paper
• SWI/SNF Complex Mutations in Gynecologic Cancers: Molecular Mechanisms and Models.

  2020cites this paper
• A report of two cases of dedifferentiated endometrioid carcinoma: A newly described underrecognized tumor of poor prognosis

  2020cites this paper
• SWI/SNF protein and claudin‐4 expression in anaplastic carcinomas arising in mucinous tumours of the ovary and retroperitoneum

  2020cites this paper
• Undifferentiated endometrial carcinoma arising in the background of high‐grade endometrial carcinoma – Expanding the definition of dedifferentiated endometrial carcinoma

  2020cites this paper
• Review of SMARCA4 (BRG1)-deficient carcinomas following a malignant pleural effusion specimen confounded by reduced claudin-4 expression.

  2020cites this paper
• SWI/SNF-deficient malignancies of the female genital tract.

  2020cites this paper
• Primary SMARCA4-deficient undifferentiated sarcomatoid tumor of the gastroesophageal junction

  2020cites this paper
• Clinico-pathological features associated with mismatch repair deficiency in endometrial undifferentiated/dedifferentiated carcinoma: A systematic review and meta-analysis.

  2020cites this paper
• Undifferentiated and dedifferentiated neoplasms of the female genital tract.

  2020cites this paper
• Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

  2020cites this paper
• SMARCA4 inactivation defines a subset of undifferentiated uterine sarcomas with rhabdoid and small cell features and germline mutation association

  2019cites this paper
• Role of epithelial–mesenchymal transition factors in the histogenesis of uterine carcinomas

  2019cites this paper
• Atlas of Uterine Pathology

  2019cites this paper
• Epithelial and Mixed Epithelial/Mesenchymal Malignancies of the Uterine Corpus

  2019cites this paper
• SMARCA4-deficient Uterine Sarcoma and Undifferentiated Endometrial Carcinoma Are Distinct Clinicopathologic Entities

  2019cites this paper
• Das un- und dedifferenzierte Endometriumkarzinom

  2019cites this paper
• SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas

  2019cites this paper
• Rapid progression of disease in two cases of undifferentiated endometrial carcinoma

  2019cites this paper
• SMARCA4-deficient Thoracic Sarcomas: Clinicopathologic Study of 30 Cases With an Emphasis on Their Nosology and Differential Diagnoses

  2019cites this paper
• Immunohistochemical correlates of recurrent genetic alterations in sarcomas

  2019cites this paper
• SMARCA4-deficient Sinonasal Carcinoma

  2017cites this paper
• Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas

  2017cites this paper