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Dorsal CA1 interneurons contribute to acute stress‐induced spatial memory deficits

Jing-Ying Yu,Ping Fang,Chi Wang,Xing-Xing Wang,Kun Li,Qian Gong,Ben-Yan Luo,Xiao-Dong Wang

Published 2018 in Neuropharmacology

ABSTRACT

&NA; Exposure to severely stressful experiences disrupts the activity of neuronal circuits and impairs declarative memory. GABAergic interneurons coordinate neuronal network activity, but their involvement in stress‐evoked memory loss remains to be elucidated. Here, we provide evidence that interneurons in area CA1 of the dorsal hippocampus partially modulate acute stress‐induced memory deficits. In adult male mice, both acute forced swim stress and restraint stress impaired hippocampus‐dependent spatial memory and increased the density of c‐fos‐positive interneurons in the dorsal CA1. Selective activation of dorsal CA1 interneurons by chemogenetics disrupted memory performance in the spatial object recognition task. In comparison, anxiety‐related behavior, spatial working memory and novel object recognition memory remained intact when dorsal CA1 interneurons were overactivated. Moreover, chemogenetic activation of dorsal CA1 interneurons suppressed the activity of adjacent pyramidal neurons, whereas a single exposure to forced swim stress but not restraint stress increased the activity of CA1 pyramidal neurons. However, chemogenetic inhibition of dorsal CA1 interneurons led to spatial memory impairments and failed to attenuate acute stress‐induced memory loss. These findings suggest that acute stress may overactivate interneurons in the dorsal CA1, which reduces the activity of pyramidal neurons and in turn disrupts long‐term memory. HighlightsAcute severe stress disrupts hippocampus‐dependent long‐term spatial memory.Acute severe stress overactivates interneurons in the mouse dorsal CA1.Chemogenetic activation of dorsal CA1 interneurons impairs spatial memory.Selective activation of dorsal CA1 interneurons reduces pyramidal neuron activity.Inhibition of CA1 interneuron activity fails to rescue stress‐induced memory loss.

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