Mechanistic insights into the activity of Ptf1-p48 (pancreas transcription factor 1a): probing the interactions levels of Ptf1-p48 with E2A-E47 (transcription factor E2-alpha) and ID3 (inhibitor of DNA binding 3)

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Biomolecular Structure and Dynamics

• Publication date

  2018-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/07391102.2017.1336487PMID 28571517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of mutants in bHLH region on structure stability and protein-DNA binding energy in DECs

  2017cited by this paper
• Structural transition of ETS1 from an auto-inhibited to functional state upon association with the p16INK4a native and mutated promoter region

  2016cited by this paper
• Interacting mechanism of ID3 HLH domain towards E2A/E12 transcription factor – An Insight through molecular dynamics and docking approach

  2015cited by this paper
• Structural perspective of ARHI mediated inhibition of STAT3 signaling: an insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ.

  2015cited by this paper
• Notch signaling in pancreatic cancer: oncogene or tumor suppressor?

  2013cited by this paper
• Local Fluctuations and Conformational Transitions in Proteins.

  2012cited by this paper
• Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants

  2012cited by this paper
• Structural insights into interacting mechanism of ID1 protein with an antagonist ID1/3-PA7 and agonist ETS-1 in treatment of ovarian cancer: molecular docking and dynamics studies

  2012cited by this paper
• Accommodating protein flexibility for structure-based drug design.

  2011cited by this paper
• Id3 modulates cellular localization of bHLH Ptf1‐p48 protein

  2011cited by this paper
• Induced fit simulations on nuclear receptors.

  2011cited by this paper
• Protein stability, flexibility and function.

  2011cited by this paper
• Improved side-chain torsion potentials for the Amber ff99SB protein force field

  2010influential reference
• I-TASSER: a unified platform for automated protein structure and function prediction

  2010cited by this paper
• Crystal contacts as nature's docking solutions

  2010influential reference
• Cancer Statistics, 2010

  2010cited by this paper
• Id1/Id3 knockdown inhibits metastatic potential of pancreatic cancer.

  2010influential reference
• The HADDOCK web server for data-driven biomolecular docking

  2010cited by this paper
• Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons

  2010cited by this paper
• DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein–protein interactions

  2010cited by this paper
• Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

  2008influential reference
• Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

  2008influential reference
• GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.

  2008cited by this paper
• I-TASSER server for protein 3D structure prediction

  2008cited by this paper
• Pancreas transcription factor 1alpha expression is regulated in pancreatitis.

  2007cited by this paper
• Free energy landscape of a biomolecule in dihedral principal component space: Sampling convergence and correspondence between structures and minima

  2007cited by this paper
• HADDOCK versus HADDOCK: New features and performance of HADDOCK2.0 on the CAPRI targets

  2007cited by this paper
• Pancreas transcription factor 1α expression is regulated in pancreatitis

  2007cited by this paper
• PTF1 Is an Organ-Specific and Notch-Independent Basic Helix-Loop-Helix Complex Containing the Mammalian Suppressor of Hairless (RBP-J) or Its Paralogue, RBP-L

  2006cited by this paper
• Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.

  2006cited by this paper
• GROMACS: Fast, flexible, and free

  2005influential reference
• Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas

  2004cited by this paper
• Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo.

  2004cited by this paper
• Discriminative topological features reveal biological network mechanisms

  2004cited by this paper
• Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.

  2003influential reference
• Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis.

  2003cited by this paper
• Predicting crystal structures: the Parrinello-Rahman method revisited.

  2002cited by this paper
• ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis.

  2000cited by this paper
• Similarities between principal components of protein dynamics and random diffusion

  2000cited by this paper
• Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.

  2000influential reference
• Identification of a novel transcriptional activity of mammalian Id proteins.

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• LINCS: A linear constraint solver for molecular simulations

  1997cited by this paper
• The p48 DNA‐binding subunit of transcription factor PTF1 is a new exocrine pancreas‐specific basic helix‐loop‐helix protein.

  1996cited by this paper
• Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase

  1995cited by this paper
• The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity

  1993cited by this paper
• Verification of protein structures: Patterns of nonbonded atomic interactions

  1993cited by this paper
• Essential dynamics of proteins

  1993cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models

  1992cited by this paper
• Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence.

  1991cited by this paper
• Id: A Negative Regulator of Helix‐Loop‐Helix DNA Binding Proteins

  1990cited by this paper
• The protein Id: a negative regulator of helix-loop-helix DNA binding proteins.

  1990cited by this paper
• Cancer statistics

  1989cited by this paper
• The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA.

  1989cited by this paper
• Conformational flexibility in protein molecules

  1979cited by this paper

• Inhibitor of DNA binding/differentiation proteins as IDs for Pancreatic cancer: Role in pancreatic cancer initiation, development and prognosis.

  2022cites this paper
• Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors

  2021cites this paper
• Innate lymphoid cell sensing of tissue vitality.

  2019cites this paper
• Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment

  2018cites this paper