Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Clinical Investigation

• Publication date

  2014-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI75572PMID 25244094PMCID PMC4191053
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2

  2014influential reference
• Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.

  2014influential reference
• Synaptotagmin‐like protein 4 and Rab8 interact and increase dense granule release in platelets

  2013cited by this paper
• Harnessing the platelet signaling network to produce an optimal hemostatic response.

  2013cited by this paper
• Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.

  2012cited by this paper
• Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.

  2012cited by this paper
• Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics.

  2012cited by this paper
• Effect of Genetic Variation in STXBP5 and STX2 on von Willebrand Factor and Bleeding Phenotype in Type 1 von Willebrand Disease Patients

  2012influential reference
• Munc18b/STXBP2 is required for platelet secretion.

  2012influential reference
• Tomosyn-dependent regulation of synaptic transmission is required for a late phase of associative odor memory

  2011cited by this paper
• Antiplatelet agents in cardiovascular disease

  2011cited by this paper
• Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes.

  2011cited by this paper
• Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels

  2011cited by this paper
• Synaptic vesicle exocytosis.

  2011cited by this paper
• Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation.

  2011cited by this paper
• Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis.

  2011cited by this paper
• Effect of Genetic Variations in Syntaxin-Binding Protein-5 and Syntaxin-2 on von Willebrand Factor Concentration and Cardiovascular Risk

  2010cited by this paper
• Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

  2010cited by this paper
• A revised model for the secretion of tPA and cytokines from cultured endothelial cells.

  2010cited by this paper
• Platelet secretion defect in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL-5).

  2010cited by this paper
• Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort.

  2010cited by this paper
• Antiplatelet therapies for the treatment of cardiovascular disease

  2010cited by this paper
• Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming.

  2009cited by this paper
• Novel copy number variants in children with autism and additional developmental anomalies

  2009cited by this paper
• Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo.

  2009cited by this paper
• Novel molecules in calcium signaling in platelets

  2009cited by this paper
• Membrane Fusion: Grappling with SNARE and SM Proteins

  2009cited by this paper
• Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release

  2008cited by this paper
• Tomosyn negatively regulates both synaptic transmitter and neuropeptide release at the C. elegans neuromuscular junction

  2007cited by this paper
• Rab27b regulates number and secretion of platelet dense granules

  2007cited by this paper
• Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.

  2007cited by this paper
• Multiple functional domains are involved in tomosyn regulation of exocytosis

  2007cited by this paper
• Tomosyn is expressed in β-cells and negatively regulates insulin exocytosis

  2006cited by this paper
• Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.

  2006cited by this paper
• Arf6 plays an early role in platelet activation by collagen and convulxin.

  2006cited by this paper
• Tomosyn-1 is involved in a post-docking event required for pancreatic β-cell exocytosis

  2006cited by this paper
• Rap1b is required for normal platelet function and hemostasis in mice.

  2005cited by this paper
• PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter

  2005cited by this paper
• Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain

  2005cited by this paper
• Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.

  2004cited by this paper
• Protein-protein interactions in platelet alphaIIbbeta3 signaling.

  2004cited by this paper
• The specificity of SNARE-dependent fusion is encoded in the SNARE motif.

  2004cited by this paper
• Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release.

  2003cited by this paper
• The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis*

  2003cited by this paper
• Tomosyn Interacts with the t-SNAREs Syntaxin4 and SNAP23 and Plays a Role in Insulin-stimulated GLUT4 Translocation*

  2003cited by this paper
• A role for Sec1/Munc18 proteins in platelet exocytosis.

  2003cited by this paper
• Normal Arp2/3 complex activation in platelets lacking WASp.

  2002cited by this paper
• Amisyn, a Novel Syntaxin-binding Protein That May Regulate SNARE Complex Assembly*

  2002cited by this paper
• A Tail Vein Bleeding Time Model and Delayed Bleeding in Hemophiliac Mice

  2001cited by this paper
• Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 and 4 in lysosome release.

  2000cited by this paper
• Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 in dense core granule release.

  2000influential reference
• Yeast Homologues of Tomosyn and lethal giant larvae Function in Exocytosis and Are Associated with the Plasma Membrane Snare, Sec9

  1999cited by this paper
• Three splicing variants of tomosyn and identification of their syntaxin-binding region.

  1999cited by this paper
• Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process.

  1998cited by this paper
• Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast.

  1998cited by this paper
• SNAREpins: minimal machinery for membrane fusion.

  1998cited by this paper
• Griscelli disease maps to chromosome 15q21 and is associated with mutations in the Myosin-Va gene

  1997cited by this paper
• The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain

  1994cited by this paper
• Synaptic vesicle exocytosis.

  1981cited by this paper

• Pilot proteomic analysis of immune dysregulation in dengue with prior SARS-CoV-2 infection

  2026cites this paper
• Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets

  2025cites this paper
• The syntaxin-binding protein STXBP5 regulates progerin expression

  2024cites this paper
• Intraplatelet miRNA-126 regulates thrombosis and its reduction contributes to platelet inhibition.

  2024cites this paper
• Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes

  2024cites this paper
• Acute Effect of Intradialytic Aerobic Exercise on Hemodynamic Response, Dialysis-Related Side Effects and Proteome in Patients with Kidney Failure: A Pilot Study

  2024cites this paper
• Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation

  2024cites this paper
• Current Understanding of Inherited Modifiers of FVIII Pharmacokinetic Variation

  2023cites this paper
• SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons

  2023cites this paper
• Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

  2023cites this paper
• Platelet-Derived Extracellular Vesicles in Arterial Thrombosis.

  2023cites this paper
• The complementary roles of VAMP-2, -3, and -7 in platelet secretion and function

  2023cites this paper
• Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes

  2023cites this paper
• The contribution of the sinusoidal endothelial cell receptors CLEC4M, stabilin-2, and SCARA5 to VWF-FVIII clearance in thrombosis and hemostasis.

  2023cites this paper
• IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis

  2022cites this paper
• Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

  2021cites this paper
• Deletion of Mfsd2b impairs thrombotic functions of platelets

  2021cites this paper
• Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling

  2021cites this paper
• Tomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors

  2020cites this paper
• Role of Kv1.3 Channels in Platelet Functions and Thrombus Formation

  2020cites this paper
• STXBP5/tomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors

  2019cites this paper
• Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects

  2019cites this paper
• Interaction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells.

  2019cites this paper
• Lysosome-related organelles as functional adaptations of the endolysosomal system.

  2019cites this paper
• Syntaxin 11 regulates platelet granule release and hemostasis

  2019cites this paper
• PLATELETS AND THROMBOPOIESIS Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis

  2019cites this paper
• Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed

  2019cites this paper
• Platelet Secretion

  2019cites this paper
• Genetic Variation in the Syntaxin-Binding Protein STXBP5 in Type 1 von Willebrand Disease Patients

  2018cites this paper
• The life cycle of platelet granules

  2018cites this paper
• CONTROLLING PLATELET SECRETION TO MODULATE HEMOSTASIS AND THROMBOSIS

  2018cites this paper
• Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability

  2018cites this paper
• Long noncoding RNA STXBP5‐AS1 inhibits cell proliferation, migration, and invasion via preventing the PI3K/AKT against STXBP5 expression in non–small‐cell lung carcinoma

  2018cites this paper
• Genetic regulation of plasma von Willebrand factor levels in health and disease

  2018cites this paper
• BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis

  2018cites this paper
• Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation

  2018cites this paper
• PLATELET ENDOCYTOSIS: ROLES IN HEMOSTASIS AND INNATE IMMUNITY

  2017cites this paper
• Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn‐1 gene

  2017cites this paper
• Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.

  2017cites this paper
• TRAF3 negatively regulates platelet activation and thrombosis

  2017cites this paper
• Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry

  2017cites this paper
• Frontline Science: Tumor necrosis factor‐α stimulation and priming of human neutrophil granule exocytosis

  2017cites this paper
• The nuts and bolts of the platelet release reaction

  2017cites this paper
• Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice

  2017cites this paper
• Host genetic effect on tuberculosis susceptibility in Chinese Uyghur

  2017cites this paper
• FUNCTIONAL ROLES FOR POST-TRANSLATIONAL MODIFICATIONS OF t-SNARES IN PLATELETS

  2016cites this paper
• Anomalies constitutionnelles de la coagulation prédisposant à la thrombose

  2016cites this paper
• Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances

  2016cites this paper
• PLATELETS AND THROMBOPOIESIS Arf 6 controls platelet spreading and clot retraction via integrin a IIb b 3 traf fi cking

  2016cites this paper
• Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.

  2016cites this paper
• Conventional and Secretory Lysosomes

  2016cites this paper
• Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.

  2016cites this paper
• B-cell–independent sialylation of IgG

  2016cites this paper
• Regulation of VWF expression, and secretion in health and disease

  2016cites this paper
• VAMP-7 links granule exocytosis to actin reorganization during platelet activation.

  2015cites this paper
• A unique SNARE machinery for exocytosis of cytotoxic granules and platelets granules

  2015cites this paper
• Title: Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis

  2015cites this paper
• Platelet secretory behaviour: as diverse as the granules … or not?

  2015cites this paper
• Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

  2015cites this paper
• Platelet granule secretion mechanisms: Are they modified in sepsis?

  2015cites this paper
• Genetics of Venous Thrombosis: update in 2015

  2015cites this paper
• Platelet secretion paves the way.

  2015cites this paper
• Impact of the serum‐ and glucocorticoid‐inducible kinase 1 on platelet dense granule biogenesis and secretion

  2015cites this paper
• Platelet secretion paves the way

  2015cites this paper
• Syntaxin-binding protein 5 exocytosis regulation: differential role in endothelial cells and platelets.

  2014influential citation