Quantized biopolymer translocation through nanopores: departure from simple scaling.

We discuss multiscale simulations of long biopolymer translocation through wide nanopores that can accommodate multiple polymer strands. The simulations provide clear evidence of folding quantization, namely the translocation proceeds through multifolded configurations characterized by a well-defined integer number of folds. As a consequence, the translocation time acquires a dependence on the average folding number, which results in a deviation from the single-exponent power law characterizing single-file translocation through narrow pores. The mechanism of folding quantization allows polymers above a threshold length (approximately 1000 persistence lengths for double-stranded DNA) to exhibit cooperative behavior, and as a result to translocate noticeably faster.

• Publication year

  2009

• Venue

  Physical review. E, Statistical, nonlinear, and soft matter physics

• Publication date

  2009-02-27

• Fields of study

  Medicine, Materials Science, Physics

• Identifiers
  DOI 10.1103/PhysRevE.79.030901arXiv 0902.4769PMID 19391890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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