Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cognitive and Behavioral Neurology

• Publication date

  2015-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1097/WNN.0000000000000071PMID 26413742PMCID PMC4588069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

  2014cited by this paper
• Cerebrospinal fluid β‐amyloid and phospho‐tau biomarker interactions affecting brain structure in preclinical Alzheimer disease

  2014cited by this paper
• Gene–Environment Interactions: Lifetime Cognitive Activity, APOE Genotype, and Beta-Amyloid Burden

  2014cited by this paper
• Molecular Pathology of Alzheimer's Disease

  2013cited by this paper
• Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.

  2013cited by this paper
• SnapShot: genetics of Alzheimer's disease.

  2013cited by this paper
• Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

  2012cited by this paper
• The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.

  2012cited by this paper
• Asymptomatic Alzheimer's disease: a prodrome or a state of resilience?

  2011cited by this paper
• Amyloid‐related imaging abnormalities in amyloid‐modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup

  2011cited by this paper
• Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

  2011cited by this paper
• Longitudinal Changes of CSF Biomarkers in Alzheimer's Disease

  2011cited by this paper
• Apolipoprotein E in Alzheimer's disease and other neurological disorders.

  2011cited by this paper
• Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB

  2010cited by this paper
• APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging

  2010influential reference
• The prevalence of what?

  2009cited by this paper
• Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

  2009cited by this paper
• Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

  2009cited by this paper
• Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.

  2009cited by this paper
• The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

  2009cited by this paper
• Frequent amyloid deposition without significant cognitive impairment among the elderly.

  2008cited by this paper
• Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease.

  2008cited by this paper
• CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study.

  2007cited by this paper
• CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment

  2007cited by this paper
• The solved and unsolved mysteries of the genetics of early-onset Alzheimer’s disease

  2007cited by this paper
• Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly

  2006cited by this paper
• Neuropathology of older persons without cognitive impairment from two community-based studies

  2006cited by this paper
• [11C]PIB in a nondemented population

  2006cited by this paper
• The Prevalence of Alzheimer Neuropathologic Lesions Is Similar in Blacks and Whites

  2006influential reference
• Cerebrospinal fluid β-amyloid 1–42 concentration may predict cognitive decline in older women

  2006cited by this paper
• Neuropathology of Down syndrome and Alzheimer disease.

  2005cited by this paper
• Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

  2004cited by this paper
• Neuropathology of Cognitively Normal Elderly

  2003cited by this paper
• Mild cognitive impairment represents early-stage Alzheimer disease.

  2001cited by this paper
• The prevalence of the neuropathological lesions of Alzheimer's disease is independent of race and gender.

  2001influential reference
• Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer’s disease

  2001cited by this paper
• “Preclinical” AD revisited

  2000cited by this paper
• Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease

  1999cited by this paper
• Alzheimer neuropathologic alterations in aged cognitively normal subjects.

  1999cited by this paper
• Neuropathological and neuropsychological changes in "normal" aging: evidence for preclinical Alzheimer disease in cognitively normal individuals.

  1998cited by this paper
• Neuropathology of preclinical and clinical lateonset Alzheimer's disease

  1998cited by this paper
• Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11, 205–242; (1968) 7, 331–356

  1997cited by this paper
• Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging.

  1996cited by this paper
• Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

  1996cited by this paper
• Health Care Worker Incidents Reported in a Rural Health Care Facility

  1996cited by this paper
• Temporal Sequence of Plaque Formation in the Cerebral Cortex of Non-Demented Individuals

  1993cited by this paper
• Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

  1993cited by this paper
• Identification of normal and pathological aging in prospectively studied nondemented elderly humans.

  1992cited by this paper
• Alzheimer's disease: the amyloid cascade hypothesis.

  1992cited by this paper
• The molecular pathology of Alzheimer's disease.

  1991cited by this paper
• Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

  1990cited by this paper
• The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome.

  1989cited by this paper
• Clinico‐pathologic studies in dementia

  1988cited by this paper
• Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

  1988cited by this paper
• A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES

  1986cited by this paper
• A descriptive study of neuritic plaques and neurofibrillary tangles in an autopsy population.

  1984cited by this paper
• The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

  1973cited by this paper
• Observations on the brains of non-demented old people.

  1968cited by this paper

• Alzheimer’s disease neuropathological change in younger individuals with IDH-mutant glioma

  2025cites this paper
• Mechanisms of Dural Involvement in Cerebral Amyloid Angiopathy

  2025cites this paper
• Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and aging

  2025cites this paper
• Molecular Framework of the Onset and Progression of Skeletal Muscle Aging

  2025cites this paper
• Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease

  2024cites this paper
• Reduced PIN1 expression in neocortical and limbic brain regions in female Alzheimer's patients correlates with cognitive and neuropathological phenotypes.

  2024cites this paper
• Reduced PIN1 gene expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypes

  2023cites this paper
• Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV

  2022cites this paper
• Prevalence and characterization of cerebral small vessel disease in young adults with intracerebral hemorrhage

  2022cites this paper
• Precision health in Alzheimer disease: Risk assessment‐based strategies

  2021cites this paper
• APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex

  2021cites this paper
• Association of midlife vascular risk and AD biomarkers with subsequent cognitive decline

  2020cites this paper
• Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

  2020cites this paper
• Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden.

  2019cites this paper
• Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network.

  2019cites this paper
• Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

  2019cites this paper
• Subthreshold amyloid and its biological and clinical meaning

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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