Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Fitoterapia

• Publication date

  2015-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.fitote.2015.06.020PMID 26136059
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The re-emergence of natural products for drug discovery in the genomics era

  2015cited by this paper
• The Old Made New: Natural Compounds against Erectile Dysfunction

  2015cited by this paper
• Erectile Dysfunction in the Elderly: An Old Widespread Issue with Novel Treatment Perspectives

  2014cited by this paper
• Treatment of erectile dysfunction: new targets and strategies from recent research.

  2014cited by this paper
• Effect of Osajin and Pomiferin on Antidiabetic Effects from Normal and Streptozotocin-induced Diabetic Rats

  2014cited by this paper
• The Fruits of Maclura pomifera Extracts Inhibits Glioma Stem-Like Cell Growth and Invasion

  2013cited by this paper
• An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors

  2013cited by this paper
• Prodrugs of N-dicarboximide derivatives of the rat selective toxicant norbormide.

  2013cited by this paper
• Treatment Strategy for Non-Responders to PDE5 Inhibitors

  2013cited by this paper
• Synthesis, docking study and relaxant effect of 2-alkyl and 2-naphthylchromones on rat aorta and guinea-pig trachea through phosphodiesterase inhibition.

  2013cited by this paper
• Nitric oxide synthases: regulation and function.

  2012cited by this paper
• Novel therapeutic strategies in the management of arterial hypertension.

  2012cited by this paper
• Emerging and Novel Therapeutic Approaches in the Treatment of Male Erectile Dysfunction

  2011cited by this paper
• Prenylated isoflavonoids: Botanical distribution, structures, biological activities and biotechnological studies. An update (1995-2006).

  2009cited by this paper
• Therapeutic targets in pulmonary arterial hypertension.

  2009cited by this paper
• Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.

  2006cited by this paper
• Vasodilatory and hypoglycaemic effects of two pyrano-isoflavone extractives from Eriosema kraussianum N. E. Br. [Fabaceae] rootstock in experimental rat models.

  2006cited by this paper
• EAU Guidelines on erectile dysfunction: an update.

  2006cited by this paper
• Recent findings on natural products with erectile-dysfunction activity.

  2003cited by this paper
• Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.

  2003cited by this paper
• Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.

  2003cited by this paper
• Sildenafil and T-1032, phosphodiesterase type 5 inhibitors, showed a different vasorelaxant property in the isolated rat aorta.

  2002cited by this paper
• Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum.

  2002cited by this paper
• Differential inhibition of multiple cAMP phosphodiesterase isozymes by isoflavones and tyrphostins.

  2000cited by this paper
• Osajin and Pomiferin, Two Isoflavones Purified from Osage Orange Fruits, Tested for Repellency to the Maize Weevil (Coleoptera: Curculionidae)

  2000cited by this paper
• Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia.

  1998cited by this paper
• Cyclic AMP-dependent phosphodiesterase isozyme-specific potentiation by protein kinase C in hypertrophic cardiomyopathic hamster hearts.

  1996cited by this paper
• Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.

  1995cited by this paper
• Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea‐pig

  1994cited by this paper
• Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

  1962cited by this paper

• Flavonoids: Potential New Drug Candidates for Attenuating Vascular Remodeling in Pulmonary Hypertension

  2025cites this paper
• Pharmacological properties of extracts and prenylated isoflavonoids from the fruits of Osage orange (Maclura pomifera (Raf.) C.K.Schneid.).

  2024cites this paper
• Pomiferin targeting SLC9A9 based on histone acetylation modification pattern is a potential therapeutical option for gastric cancer with high malignancy.

  2024cites this paper
• Current insights and future perspectives of flavonoids: A promising antihypertensive approach

  2024cites this paper
• In Silico Study of α-Amylase and α-Glucosidase Inhibitory Compounds in Aloe vera as Antidiabetic Agent

  2023cites this paper
• Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model

  2023cites this paper
• Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo.

  2023cites this paper
• Identification of potential inhibitors of PDE5 based on structure-based virtual screening approaches.

  2022cites this paper
• Virtual screening and in vitro experiments highlight cannabidiol as a drug‐like phosphodiesterase 9 inhibitor

  2022cites this paper
• Multi-target Natural and Nature-Inspired Compounds against Neurodegeneration: A Focus on Dual Cholinesterase and Phosphodiesterase Inhibitors

  2021cites this paper
• A Perspective on Natural and Nature-Inspired Small Molecules Targeting Phosphodiesterase 9 (PDE9): Chances and Challenges against Neurodegeneration

  2021cites this paper
• Synthesis and Biological Activity of Triazole Derivatives of Osajin

  2021cites this paper
• Natural Molecules as Talented Inhibitors of Nucleotide Pyrophosphatases/Phosphodiesterases (PDEs).

  2021cites this paper
• Therapeutic Potential of Phosphodiesterase Inhibitors against Neurodegeneration: The Perspective of the Medicinal Chemist

  2020cites this paper
• Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts

  2020cites this paper
• Combinatorial library generation, molecular docking and molecular dynamics simulations for enhancing the isoflavone scaffold in phosphodiesterase inhibition

  2020cites this paper
• 2-(3,4-Dihydroxyphenyl)-4-(2-(4-nitrophenyl)hydrazono)-4H-chromene-3,5,7-triol

  2020cites this paper
• H -chromene-3,5,7-triol

  2020cites this paper
• Photoactivated semi-synthetic derivative of osajin selectively interacts with G-quadruplex DNA

  2020cites this paper
• Natural Compounds Promoting Weight Loss: Mechanistic Insights from the Point of View of the Medicinal Chemist

  2019cites this paper
• Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer's disease.

  2019cites this paper
• A concise review of recent advances in anti-heart failure targets and its small molecules inhibitors in recent years.

  2019cites this paper
• The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo

  2019cites this paper
• Natural phosphodiesterase 5 (PDE5) inhibitors: a computational approach

  2019cites this paper
• 5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one

  2018cites this paper
• Phosphodiesterase 5 Inhibitors from Derris scandens

  2018cites this paper
• Isoflavones from Maclura pomifera: structural elucidation and in silico evaluation of their interaction with PDE5

  2017influential citation
• Identi�cation of potential inhibitors of PDE5 based on structure-based virtual screening approaches

  year unknowncites this paper