Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development

Chen et al. find that loss of function in ssup-72, a Ser5 phosphatase for the RNA polymerase II C-terminal domain (CTD), dampens transcription termination at a strong intronic poly(A) site (PAS) in unc-44/ankyrin yet promotes termination at the weak intronic PAS of the MAP kinase dlk-1. This work reveals a mechanism by which regulation of CTD phosphorylation controls coding region alternative polyadenylation in the nervous system.

• Publication year

  2015

• Venue

  Genes & Development

• Publication date

  2015-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.266650.115PMID 26588990PMCID 4691892
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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