Spermiogenesis and DNA Repair: A Possible Etiology of Human Infertility and Genetic Disorders

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Systems Biology in Reproductive Medicine

• Publication date

  2008-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/19396360701876823PMID 18543861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effects of male age on sperm DNA damage in healthy non-smokers.

  2007cited by this paper
• Mutations in the protamine 1 gene associated with male infertility.

  2007cited by this paper
• Altered protamine expression and diminished spermatogenesis: what is the link?

  2007cited by this paper
• H2AX foci in late S/G2- and M-phase cells after hydroxyurea- and aphidicolin-induced DNA replication stress in Vicia

  2007cited by this paper
• Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis

  2006cited by this paper
• ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment.

  2006cited by this paper
• Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin.

  2006cited by this paper
• Advancing paternal age and autism.

  2006cited by this paper
• Paternal Age and Spontaneous Abortion

  2006cited by this paper
• Clinical aspects of sperm DNA fragmentation detection and male infertility.

  2006cited by this paper
• Chromatin modulation and the DNA damage response.

  2006cited by this paper
• Protamines and male infertility.

  2006cited by this paper
• A novel mechanism of protamine expression deregulation highlighted by abnormal protamine transcript retention in infertile human males with sperm protamine deficiency.

  2006cited by this paper
• Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

  2006cited by this paper
• Polyamine deficiency leads to accumulation of reactive oxygen species in a spe2Δ mutant of Saccharomyces cerevisiae

  2006cited by this paper
• DNA damage in bovine sperm does not block fertilization and early embryonic development but induces apoptosis after the first cleavages.

  2006cited by this paper
• Male genital tract antioxidant enzymes--their ability to preserve sperm DNA integrity.

  2006cited by this paper
• Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

  2006cited by this paper
• The effect of epigenetic sperm abnormalities on early embryogenesis.

  2006cited by this paper
• Origin and biological significance of DNA fragmentation in human spermatozoa.

  2006cited by this paper
• Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrity.

  2006cited by this paper
• Sperm nuclear DNA damage: update on the mechanism, diagnosis and treatment.

  2006cited by this paper
• Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).

  2006cited by this paper
• Polyamines protect against radiation-induced oxidative stress.

  2005cited by this paper
• A comparative study of oxidative DNA damage in mammalian spermatozoa

  2005cited by this paper
• Mechanisms and consequences of paternally-transmitted chromosomal abnormalities.

  2005cited by this paper
• On the Nature and Origin of DNA Strand Breaks in Elongating Spermatids1

  2005cited by this paper
• CHROMATIN REMODELING IN SPERMATIDS: A SENSITIVE STEP FOR THE GENETIC INTEGRITY OF THE MALE GAMETE

  2005cited by this paper
• Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis

  2005cited by this paper
• Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages*

  2005cited by this paper
• Role of antioxidants in treatment of male infertility: an overview of the literature.

  2004cited by this paper
• Transition nuclear proteins are required for normal chromatin condensation and functional sperm development

  2004cited by this paper
• Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation.

  2004cited by this paper
• Chromosome regions enriched in hyperacetylated histone H4 are preferred sites for endonuclease- and radiation-induced breakpoints

  2004cited by this paper
• Transient DNA Strand Breaks During Mouse and Human Spermiogenesis: New Insights in Stage Specificity and Link to Chromatin Remodeling1

  2004influential reference
• Impairment of spermatogenesis leading to infertility

  2004cited by this paper
• Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles.

  2004cited by this paper
• Abnormalities and Reduced Reproductive Potential of Sperm from Tnp1- and Tnp2-Null Double Mutant Mice1

  2004cited by this paper
• Expression of mammalian spermatozoal nucleoproteins

  2003cited by this paper
• Polyamines protect Escherichia coli cells from the toxic effect of oxygen

  2003cited by this paper
• The influence of paternal age on down syndrome.

  2003cited by this paper
• Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice1

  2003cited by this paper
• Ability of Hamster Spermatozoa to Digest Their Own DNA1

  2003cited by this paper
• The Structural Organization of Sperm Chromatin*

  2003cited by this paper
• Repair in haploid male germ cells occurs late in differentiation as chromatin is condensing

  2003cited by this paper
• Caspase activity and apoptotic markers in ejaculated human sperm.

  2002cited by this paper
• Nature of DNA Damage in Ejaculated Human Spermatozoa and the Possible Involvement of Apoptosis1

  2002cited by this paper
• Expression of hyperacetylated histone H4 during normal and impaired human spermatogenesis

  2002cited by this paper
• Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase λ-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome

  2002cited by this paper
• Oxidative stress, DNA damage and the Y chromosome.

  2001cited by this paper
• Highly efficient base excision repair (BER) in human and rat male germ cells.

  2001cited by this paper
• Trinucleotide expansion in haploid germ cells by gap repair

  2001cited by this paper
• Advancing paternal age and the risk of schizophrenia.

  2001cited by this paper
• Transition nuclear proteins during spermiogenesis: Unrepaired DNA breaks not allowed

  2001cited by this paper
• Stimulation of DNA repair by the spermatidal TP1 protein

  2001cited by this paper
• Differences in nuclear DNA fragmentation and mitochondrial integrity of semen and prepared human spermatozoa.

  2000cited by this paper
• Study of apoptotic DNA fragmentation in human spermatozoa.

  2000cited by this paper
• Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4

  2000influential reference
• DNA integrity in human spermatozoa: relationships with semen quality.

  2000cited by this paper
• Functional and ultrastructural features of DNA-fragmented human sperm.

  2000cited by this paper
• Origin of DNA damage in ejaculated human spermatozoa.

  1999cited by this paper
• Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

  1999cited by this paper
• Architectural DNA-binding properties of the spermatidal transition proteins 1 and 2.

  1998cited by this paper
• The effect of follicle stimulating hormone therapy on human sperm structure (Notulae seminologicae 11).

  1997cited by this paper
• Analysis of expression and function of topoisomerase I and II during meiosis in male mice

  1997cited by this paper
• Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

  1996cited by this paper
• Expression and localization of DNA topoisomerase II during rat spermatogenesis

  1996cited by this paper
• Presence of endogenous nicks in DNA of ejaculated human spermatozoa and its relationship to chromomycin A3 accessibility.

  1995cited by this paper
• Premature translation of protamine 1 mRNA causes precocious nuclear condensation and arrests spermatid differentiation in mice.

  1995cited by this paper
• Nicking of rat spermatid and spermatozoa DNA: possible involvement of DNA topoisomerase II.

  1993cited by this paper
• Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells.

  1993cited by this paper
• Localization of DNase I‐hypersensitive regions during rat spermatogenesis: Stage‐dependent patterns and unique sensitivity of elongating spermatids

  1992cited by this paper
• DNA topoisomerase II activity in nonreplicating, transcriptionally inactive, chicken late spermatids.

  1989cited by this paper
• DNA synthesis catalysed by endogenous templates and DNA-dependent DNA polymerases in spermatogenic cells from rat.

  1981cited by this paper

• Correlation between sperm DNA fragmentation and methylation in male partners of couples with idiopathic recurrent pregnancy loss

  2024cites this paper
• Exploring the Mechanisms of Yishen Tongluo Decoction on Repairing DNA Damage in Mouse Spermatogonia Cells Based on Whole Transcriptome Sequencing

  2024cites this paper
• Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

  2023cites this paper
• Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations

  2023cites this paper
• Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI

  2022cites this paper
• Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia

  2022cites this paper
• Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection.

  2021cites this paper
• Thymoquinone enhances sperm DNA integrity in nicotineinduced infertile male rats

  2021cites this paper
• Paternal Fenitrothion Exposures in Rats Causes Sperm DNA Fragmentation in F0 and Histomorphometric Changes in Selected Organs of F1 Generation

  2021cites this paper
• JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway

  2021cites this paper
• Preferentially Paternal Origin of De Novo 11p13 Chromosome Deletions Revealed in Patients with Congenital Aniridia and WAGR Syndrome

  2020cites this paper
• Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate

  2020cites this paper
• Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort.

  2019cites this paper
• Pathologies des hélicases et vieillissement précoce : modèle d’étude par dérivation de cellules souches pluripotentes induites

  2019cites this paper
• Robotic Manipulation and Selection of Single Sperm for In Vitro Fertilization

  2019cites this paper
• Grades 2/3 Varicocele and Normal Conventional Semen Analysis

  2019cites this paper
• DNA Damage and Repair in Human Reproductive Cells

  2018cites this paper
• Fatherhood and Sperm DNA Damage in Testicular Cancer Patients

  2018cites this paper
• Heat exposure induces oxidative stress and dna damage in the male germ line†

  2018cites this paper
• Defective DNA Repair in Spermiogenesis

  2018cites this paper
• TSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis

  2017cites this paper
• Towards an Understanding of the Role of Cation Packaging on DNA Protection from Oxidative Damage

  2017cites this paper
• FSH treatment in infertile males candidate to assisted reproduction improved sperm DNA fragmentation and pregnancy rate

  2017cites this paper
• Genetic Aspect of Recurrent Implantation Failure

  2017cites this paper
• Heritable sperm chromatin epigenetics: A break to remember †

  2017cites this paper
• Oxidative stress level in fresh ejaculate is not related to semen parameters or to pregnancy rates in cycles with donor oocytes

  2016cites this paper
• Male Factors in Recurrent Pregnancy Loss

  2016cites this paper
• Mechanisms of germ line genome instability.

  2016cites this paper
• Relationship between Potential Sperm Factors Involved in Oocyte Activation and Sperm DNA Fragmentation with Intra-Cytoplasmic Sperm Injection Clinical Outcomes

  2016cites this paper
• A comparison of the effect of Polyvinylpyrrolidone (PVP) and SpermSlow on human spermatozoa

  2015influential citation
• Uncoupling of transcription and translation of Fanconi anemia (FANC) complex proteins during spermatogenesis

  2015cites this paper
• Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility.

  2015cites this paper
• [Chromothripsis, an unexpected novel form of complexity for chromosomal rearrangements].

  2014cites this paper
• Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility.

  2014cites this paper
• Human Sperm DNA Fragmentation and its Correlation with Conventional Semen Parameters

  2014cites this paper
• Assessing sperm chromatin and DNA damage: clinical importance and development of standards

  2014cites this paper
• Recent knowledge concerning mammalian sperm chromatin organization and its potential weaknesses when facing oxidative challenge

  2014cites this paper
• Deletions and duplications of the 22q11.2 region in spermatozoa from DiGeorge/velocardiofacial fathers

  2014cites this paper
• Male infertility: biomolecular aspects

  2014cites this paper
• Development of an in vitro test system for assessment of male, reproductive toxicity.

  2014cites this paper
• Which isolated sperm abnormality is most related to sperm DNA damage in men presenting for infertility evaluation

  2014cites this paper
• A pregnancy with discordant fetal and placental chromosome 18 aneuploidies revealed by invasive and noninvasive prenatal diagnosis.

  2014cites this paper
• Lower sperm DNA fragmentation after r-FSH administration in functional hypogonadotropic hypogonadism

  2013cites this paper
• Females and Males Contribute in Opposite Ways to the Evolution of Gene Order in Drosophila

  2013cites this paper
• Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse

  2013cites this paper
• Sperm DNA and chromatin integrity in semen samples used for intrauterine insemination

  2013cites this paper
• Oxidative stress and male reproductive health

  2013cites this paper
• Birth seasonality in Prader‐Willi syndrome resulting from chromosome 15 microdeletion

  2013cites this paper
• Chromothripsis in congenital disorders and cancer: similarities and differences.

  2013cites this paper
• Birth defects: Risk factors and consequences

  2013cites this paper
• Chromatin structure analysis of spermatozoa from reciprocal chromosome translocation (RCT) carriers with known meiotic segregation patterns.

  2013cites this paper
• The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1

  2013cites this paper
• Evaluation of spermatozoa DNA tests for an assisted reproductive techniques (ART) program : correlation with semen parameters and ART outcome

  2013influential citation
• The Influence of Parental Factors on the Growth and Metabolism of Children

  2013cites this paper
• Caractérisation initiale de l'instabilité génétique des spermatides de mammifères

  2012cites this paper
• A cytological exploration of human spermatogenesis in non-obstructive azoospermia patients: an analysis of variation

  2012cites this paper
• Direct and delayed X‐ray‐induced DNA damage in male mouse germ cells

  2012cites this paper
• DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.

  2012cites this paper
• The presence of a truncated base excision repair pathway in human spermatozoa , mediated by OGG 1

  2012cites this paper
• Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones

  2012cites this paper
• In vitro effects of α‐tocopherol on teratozoospermic semen samples

  2012cites this paper
• DNA repair mechanisms in mammalian germ cells.

  2011cites this paper
• Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?

  2011cites this paper
• Environmental car exhaust pollution damages human sperm chromatin and DNA

  2011cites this paper
• Male Subfertility and Sperm Chromatin Damage

  2011cites this paper
• The sperm nucleus: chromatin, RNA, and the nuclear matrix.

  2011cites this paper
• The Role of the Oocyte in Remodeling of Male Chromatin and DNA Repair: Are Events During the Zygotic Cell Cycle of Relevance to ART?

  2011cites this paper
• Histone Variants during Gametogenesis and Early Development

  2011cites this paper
• Review DNA repair mechanisms in mammalian germ cells

  2011cites this paper
• Post-Meiotic DNA Damage and Response in Male Germ Cells

  2011cites this paper
• Withania somnifera improves semen quality by combating oxidative stress and cell death and improving essential metal concentrations.

  2011cites this paper
• Prognostic markers for competent human spermatozoa: fertilizing capacity and contribution to the embryo.

  2011cites this paper
• Protamine/DNA ratios and DNA damage in native and density gradient centrifuged sperm from infertile patients.

  2011cites this paper
• In smokers, swim-up and discontinuous gradient centrifugation recover spermatozoa with equally lower amounts of DNA damage than spermatozoa obtained from neat semen.

  2011cites this paper
• Mammalian Spermatogenesis, DNA Repair, Poly(ADP-ribose) Turnover: the State of the Art

  2011cites this paper
• Are sperm chromatin and DNA defects relevant in the clinic?

  2011cites this paper
• Sperm chromatin protamination: an endocrine perspective.

  2011cites this paper
• Medical Implications of Sperm Nuclear Quality

  2011cites this paper
• FATS is a transcriptional target of p53 and associated with antitumor activity

  2010cites this paper
• Deletions and duplications of the 15q11-q13 region in spermatozoa from Prader-Willi syndrome fathers.

  2010cites this paper
• The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements

  2010cites this paper
• Disruption of Poly(ADP-Ribose) Homeostasis Affects Spermiogenesis and Sperm Chromatin Integrity in Mice1

  2009cites this paper
• Chromatin loops, illegitimate recombination, and genome evolution

  2009cites this paper
• Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse.

  2009cites this paper
• Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: Changes in spermatid organelles associated with development of spermatozoa

  2009cites this paper
• Plants Used in Chinese Medicine for the Treatment of Male Infertility Possess Antioxidant and Anti-Oestrogenic Activity

  2008cites this paper