Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla

Aims: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). Materials and Methods: Thirty healthy subjects (mean age = 44.2 years, range = 20–72 years) were enrolled for this study. Mean values of MD and FA in six spinal levels (C2/3, C3/4, C4/5, C5/6, C6/7, and C7/Th1) were measured. Mean values, variances, and distributions of the MD and FA in each spinal level were analyzed. Age-dependent change of MD and FA as well as correlation between MD and FA was also analyzed. Results: At all spinal levels, the values can be considered to be Gaussian distribution in MD but not in FA. A significant statistical negative correlation was observed between aging and the values of MD (r = 0.429, P = 0.018), but insignificant between the values of FA (P = 0.234). A slight significant statistical negative correlation was observed between the values of MD and FA (r = 0.156, P = 0.037). One way repeated measures analysis of variance indicated the significant difference between the spinal levels in both MD (P = 0.003) and FA (P < 0.0001). Conclusions: The analyzed data in the present study would be helpful for comparison when investigating the spinal condition of spinal disorders.

• Publication year

  2011

• Venue

  Journal of Craniovertebral Junction and Spine

• Publication date

  2011-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4103/0974-8237.100060PMID 23125493PMCID 3486000
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dependence of the fractional anisotropy in cervical spine from the number of diffusion gradients, repeated acquisition and voxel size.

  2010cited by this paper
• A diffusion tensor imaging group study of the spinal cord in multiple sclerosis patients with and without T2 spinal cord lesions

  2009cited by this paper
• Diffusion Tensor MR Imaging in Chronic Spinal Cord Injury

  2008cited by this paper
• Diffusion tensor imaging of the cortico-ponto-cerebellar pathway in patients with adult-onset ataxic neurodegenerative disease

  2008cited by this paper
• Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis

  2007cited by this paper
• Diffusion tensor imaging of the brain

  2007cited by this paper
• Evidence for cervical cord tissue disorganisation with aging by diffusion tensor MRI

  2007cited by this paper
• Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis

  2006cited by this paper
• Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord.

  2006cited by this paper
• Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI

  2006cited by this paper
• Line scan diffusion tensor MRI at low magnetic field strength: Feasibility study of cervical spondylotic myelopathy in an early clinical stage

  2006cited by this paper
• Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI

  2005cited by this paper
• Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients

  2005cited by this paper
• Apparent diffusion coefficient and fractional anisotropy in spinal cord: Age and cervical spondylosis–related changes

  2005cited by this paper
• Single-shot fast spin-echo diffusion tensor imaging of the brain and spine with head and phased array coils at 1.5 T and 3.0 T.

  2004cited by this paper
• Diffusion tensor MRI as a diagnostic tool of upper motor neuron involvement in amyotrophic lateral sclerosis.

  2004cited by this paper
• Line scan diffusion imaging of the spine.

  2003cited by this paper
• On the application of a non‐CPMG single‐shot fast spin‐echo sequence to diffusion tensor MRI of the human brain

  2002cited by this paper
• Multishot diffusion‐weighted FSE using PROPELLER MRI

  2002cited by this paper
• Investigating Cervical Spinal Cord Structure Using Axial Diffusion Tensor Imaging

  2002influential reference
• Diffusion tensor imaging: Concepts and applications

  2001cited by this paper
• Line scan diffusion tensor MRI of the cervical spinal cord in preterm infants

  2001cited by this paper
• Diffusion tensor MRI of the spinal cord

  2000cited by this paper
• MR line-scan diffusion imaging of the spinal cord in children.

  2000cited by this paper
• Motion correction with PROPELLER MRI: Application to head motion and free‐breathing cardiac imaging

  1999cited by this paper
• Phase insensitive preparation of single‐shot RARE: Application to diffusion imaging in humans

  1997cited by this paper
• Line scan diffusion imaging

  1996cited by this paper
• Toward a quantitative assessment of diffusion anisotropy

  1996cited by this paper
• Grading and scoring system for neurological function in degenerative cervical spine disease--Neurosurgical Cervical Spine Scale.

  1992cited by this paper
• Echo-planar imaging of intravoxel incoherent motion.

  1990cited by this paper

• Role of diffusion tensor imaging in stenotic and non-stenotic spinal canal.

  2023cites this paper
• Porcine Model of the Growing Spinal Cord—Changes in Diffusion Tensor Imaging Parameters

  2023cites this paper
• The role of diffusion tensor imaging in the diagnosis, prognosis, and assessment of recovery and treatment of spinal cord injury: a systematic review.

  2019cites this paper
• Management of the Patient with Cervical Cord Compression but no Evidence of Myelopathy: What Should We do?

  2018cites this paper
• Titre : Title : ZOOM or non-ZOOM ? Assessing spinal cord diffusion tensor imaging protocols for multi-centre studies Auteurs :

  2018cites this paper
• ZOOM or Non-ZOOM? Assessing Spinal Cord Diffusion Tensor Imaging Protocols for Multi-Centre Studies

  2016cites this paper
• Diffusion tensor imaging observation in Pott's spine with or without neurological deficit

  2015cites this paper
• Accuracy of Diffusion Tensor Imaging for Diagnosing Cervical Spondylotic Myelopathy in Patients Showing Spinal Cord Compression

  2015cites this paper
• Prediction of the efficacy of surgical intervention in patients with cervical myelopathy by using diffusion tensor 3T-magnetic resonance imaging parameters

  2015cites this paper