The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input

Acute inflammation engages various descending control systems in the brain that alter the resulting inflammatory pain, usually by inhibiting it. In this study we looked at the differences in inhibition of acute (up to 3 h) inflammatory pain from smooth (glabrous) and hairy skin in the rat hind foot. In hairy skin, inflammatory pain is rapidly inhibited by descending systems that release noradrenaline, but not opiates, into the spinal cord. In glabrous skin, neither descending noradrenergic nor opioidergic controls affect inflammatory pain. These results tell us that the controls on the spinal processing of cutaneous inflammatory pain differ according to the skin type affected.

• Publication year

  2014

• Venue

  Journal of Physiology

• Publication date

  2014-06-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2013.266494PMID 24879873PMCID 4229351
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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