Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy.

Ubiquitin carboxyl-terminal hydrolase 37 (UCH37, also called UCHL5), a member of the deubiquitinating enzymes, can suppress protein degradation through disassembling polyubiquitin from the distal subunit of the chain. It has been proved that UCH37 can be activated by proteasome ubiqutin chain receptor Rpn13 and incorporation into the 19S complex. UCH37, which has been reported to assist in the mental development of mice, may play an important role in oncogenesis, tumor invasion and migration. Further studies will allow a better understanding of roles in cell physiology and pathology, embryonic development and tumor formation, hopefully providing support for the idea that UCH37 may constitute a new interesting target for the development of anticancer drugs.

• Publication year

  2013

• Venue

  Asian Pacific Journal of Cancer Prevention

• Publication date

  2013-04-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.7314/APJCP.2013.14.4.2173PMID 23725108
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• UCH37 may play an important role in oncogenesis, tumor invasion, and migration, positioning it as a candidate anticancer drug target.

  Confidence 0.78

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• UCH37 is activated by proteasome ubiquitin chain receptor Rpn13 and through incorporation into the 19S proteasome complex.

  Confidence 0.85

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• 19s proteasome complex

  protein complex

  A regulatory subunit of the proteasome that UCH37 incorporates into upon activation by Rpn13.

  Aliases: 19S complex

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• deubiquitinating enzymes

  enzyme class

  A class of enzymes that remove or trim ubiquitin from substrates, to which UCH37 belongs.

  Aliases: DUBs

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• oncogenesis

  biological process

  The cellular process leading to tumor formation, in which UCH37 is proposed to play a functional role.

  Aliases: tumor formation, tumorigenesis

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• polyubiquitin chain

  molecular structure

  A chain of linked ubiquitin molecules that UCH37 disassembles from the distal subunit to suppress proteasomal degradation.

  Aliases: polyubiquitin

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• rpn13

  protein, receptor

  A proteasome ubiquitin chain receptor that activates UCH37 and mediates its incorporation into the 19S proteasome complex.

  Aliases: proteasome ubiquitin chain receptor Rpn13

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• tumor invasion and migration

  biological process, disease process

  Cancer cell behaviors involving tissue penetration and movement, processes in which UCH37 is suggested to be involved.

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• uch37

  protein, enzyme

  A deubiquitinating enzyme that suppresses protein degradation by disassembling polyubiquitin chains from the distal subunit of the chain.

  Aliases: UCHL5, ubiquitin carboxyl-terminal hydrolase 37

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