Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

Laura C. McCaughey,I. Josts,R. Grinter,P. White,O. Byron,N. Tucker,J. Matthews,C. Kleanthous,C. Whitchurch,D. Walker

Published 2016 in Biochemical Journal

ABSTRACT

Here we propose a mechanism of cell targeting and translocation for an S-type pyocin, pyocin SD2. Understanding and exploiting the mechanisms by which pyocins target, penetrate and kill Pseudomonas aeruginosa is a promising approach to antibiotic development.

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