Functional characterization and virulence study of ADE8 and GUA1 genes involved in the de novo purine biosynthesis in Candida albicans.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  FEMS Yeast Research

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1567-1364.2009.00600.xPMID 20082641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans*

  2009cited by this paper
• Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations.

  2008influential reference
• Spectrum and risk factors for invasive candidiasis and non-Candida fungal infections after liver transplantation.

  2008cited by this paper
• Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery

  2008cited by this paper
• The gene for cobalamin-independent methionine synthase is essential in Candida albicans: a potential antifungal target.

  2007cited by this paper
• Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

  2007cited by this paper
• Risk of resistance associated with fluconazole prophylaxis: systematic review.

  2007cited by this paper
• Identification and characterization of a functional Candida albicans homolog of the Saccharomyces cerevisiae TCO89 gene.

  2007cited by this paper
• Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus.

  2007cited by this paper
• Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis.

  2006cited by this paper
• Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient.

  2006cited by this paper
• Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen Candida albicans

  2005influential reference
• Ectopic Expression of URA3 Can Influence the Virulence Phenotypes and Proteome of Candida albicans but Can Be Overcome by Targeted Reintegration of URA3 at the RPS10 Locus

  2004cited by this paper
• The serine/threonine protein phosphatase SIT4 modulates yeast‐to‐hypha morphogenesis and virulence in Candida albicans

  2004cited by this paper
• Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

  2003cited by this paper
• Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans.

  2001cited by this paper
• The glyoxylate cycle is required for fungal virulence

  2001cited by this paper
• 123I-labelled vasoactive intestinal peptide receptor scintigraphy in patients with colorectal cancer.

  1998cited by this paper
• New antimetabolites in cancer chemotherapy and their clinical impact.

  1998influential reference
• Avirulence of Candida albicans FAS2 mutants in a mouse model of systemic candidiasis

  1997influential reference
• Isogenic strain construction and gene mapping in Candida albicans.

  1993cited by this paper
• 6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae

  1992cited by this paper
• The renewed potential for folate antagonists in contemporary cancer chemotherapy.

  1991cited by this paper

• Purine metabolism in plant pathogenic fungi

  2024cites this paper
• Multi-site microbiota alteration is a hallmark of kidney stone formation

  2023cites this paper
• Grf10 regulates the response to copper, iron, and phosphate in Candida albicans

  2023cites this paper
• GAR-transferase contributes to purine synthesis and mitochondrion function to maintain fungal development and full virulence of Penicillium digitatum.

  2023cites this paper
• De novo purine nucleotide biosynthesis mediated by MoAde4 is required for conidiation, host colonization and pathogenicity in Magnaporthe oryzae

  2022cites this paper
• Primary Metabolism of Human Pathogenic Fungi, Importance for Virulence and Potential for Drug Development

  2021cites this paper
• Stage-specific regulation of purine metabolism during infectious growth and sexual reproduction in Fusarium graminearum.

  2021cites this paper
• Insight into the Antioxidant Effect of Fermented and Non-Fermented Spirulina Water and Ethanol Extracts at the Proteome Level Using a Yeast Cell Model

  2021cites this paper
• De novo purine nucleotide biosynthesis mediated by amidophosphoribosyl transferase is required for conidiation and essential for the successful host colonization of Magnaporthe oryzae

  2021cites this paper
• Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway

  2020cites this paper
• Interactions of GMP with Human Glrx3 and with <named-content content-type='genus-species'>Saccharomyces cerevisiae</named-content> Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway

  2020cites this paper
• Small extracellular vesicles secreted by Candida albicans hyphae have highly diverse protein cargoes that include virulence factors and stimulate macrophages

  2020cites this paper
• Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans

  2020cites this paper
• Global proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida albicans virulence and biofilm formation

  2020cites this paper
• The lipid flippase subunit Cdc50 is required for antifungal drug resistance, endocytosis, hyphal development and virulence in Candida albicans.

  2019cites this paper
• A Tet-Off gene expression system for validation of antifungal drug targets in a murine invasive pulmonary aspergillosis model

  2018cites this paper
• Generation of gua1 deletion using polymerase chain reaction (PCR)-mediated gene disruption method in fission yeast, Schizosaccharomyces pombe

  2017cites this paper
• Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

  2017cites this paper
• Identification of factors involved in dimorphism and pathogenicity of Zymoseptoria tritici

  2017cites this paper
• Grf10 and Bas1 Regulate Transcription of Adenylate and One-Carbon Biosynthesis Genes and Affect Virulence in the Human Fungal Pathogen Candida albicans

  2017cites this paper
• The Atypical Guanylate Kinase MoGuk2 Plays Important Roles in Asexual/Sexual Development, Conidial Septation, and Pathogenicity in the Rice Blast Fungus

  2017cites this paper
• Purine Acquisition and Synthesis by Human Fungal Pathogens

  2017cites this paper
• GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans*

  2017cites this paper
• Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

  2016cites this paper
• Opportunistic Strains of Saccharomyces cerevisiae: A Potential Risk Sold in Food Products

  2016cites this paper
• Comparative Genomic Analysis Reveals a Critical Role of De Novo Nucleotide Biosynthesis for Saccharomyces cerevisiae Virulence

  2015cites this paper
• GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway

  2015cites this paper
• Growth in rice cells requires de novo purine biosynthesis by the blast fungus Magnaporthe oryzae

  2013cites this paper
• De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

  2012cites this paper