Nuclear Medicine Procedures in Women: Unappreciated Risks to Reproductive Organs?

The recent explosion in development of new radiotracers for cancer diagnosis and targeted therapy, many of which target biomolecules, which vary in abundance as a function of hormonal milieu, poses a disproportionate risk of adverse effects in women of reproductive age.

• Publication year

  2018

• Venue

  Radiology

• Publication date

  2018-07-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.1148/radiol.2018172344PMID 29989525
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacokinetics, Biodistribution, and Radiation Dosimetry for 89Zr-Trastuzumab in Patients with Esophagogastric Cancer

  2018cited by this paper
• Biodistribution and Dosimetry of 18F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies

  2018cited by this paper
• A phase one, single-dose, open-label, clinical safety and PET/MR imaging study of 68Ga-DOTATOC in healthy volunteers.

  2017cited by this paper
• Exposure to low dose computed tomography for lung cancer screening and risk of cancer: secondary analysis of trial data and risk-benefit analysis

  2017cited by this paper
• Radiation dose reduction in thoracic and lumbar spine instrumentation using navigation based on an intraoperative cone beam CT imaging system: a prospective randomized clinical trial

  2017cited by this paper
• Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans

  2017cited by this paper
• Radiation dose-reduction strategies in thoracic CT.

  2017cited by this paper
• Low-Dose CT of the Paranasal Sinuses: Minimizing X-Ray Exposure with Spectral Shaping

  2016cited by this paper
• The Use of Novel PET Tracers to Image Breast Cancer Biologic Processes Such as Proliferation, DNA Damage and Repair, and Angiogenesis

  2016cited by this paper
• Targeted Radionuclide Therapy of Human Tumors

  2015cited by this paper
• Aromatase Imaging with [N-Methyl-11C]Vorozole PET in Healthy Men and Women

  2015cited by this paper
• The endocrinology of the menstrual cycle.

  2014cited by this paper
• Failure to consider the menstrual cycle phase may cause misinterpretation of clinical and research findings of cardiometabolic biomarkers in premenopausal women.

  2014cited by this paper
• PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

  2014cited by this paper
• Discussion on the alteration of 18F-FDG uptake by the breast according to the menstrual cycle in PET imaging

  2013cited by this paper
• Medical imaging radiation safety for the female patient: rationale and implementation.

  2012cited by this paper
• Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies

  2011cited by this paper
• Somatostatin Receptors as Targets for Nuclear Medicine Imaging and Radionuclide Treatment

  2011cited by this paper
• Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions.

  2010cited by this paper
• Radiation doses and cancer risks from breast imaging studies.

  2010cited by this paper
• Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer.

  2009cited by this paper
• Exposure to low-dose ionizing radiation from medical imaging procedures.

  2009cited by this paper
• Whole-body PET/CT scanning: estimation of radiation dose and cancer risk.

  2009cited by this paper
• Benign ovarian and endometrial uptake on FDG PET-CT: patterns and pitfalls

  2009cited by this paper
• Gender bias in research: how does it affect evidence based medicine?

  2007cited by this paper
• Correlation between the intensity of breast FDG uptake and menstrual cycle.

  2007cited by this paper
• Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2.

  2006cited by this paper
• Physiological 18F-FDG uptake in the ovaries and uterus of healthy female volunteers

  2005cited by this paper
• Normal and abnormal 18F-FDG endometrial and ovarian uptake in pre- and postmenopausal patients: assessment by PET/CT.

  2004cited by this paper
• Characterization of Cyclin D2 Expression in Human Endometrium

  2002cited by this paper
• Somatostatin receptor 2 expression in the human endometrium through the menstrual cycle

  2002cited by this paper
• Endometrial expression and secretion of interleukin-6 throughout the menstrual cycle

  2002cited by this paper
• Cycle-Dependent Expression of Interleukin-1 Receptor Type II in the Human Endometrium1

  2001cited by this paper
• Expression, localization, and signaling of PGE(2) and EP2/EP4 receptors in human nonpregnant endometrium across the menstrual cycle.

  2001cited by this paper
• Endometrial osteopontin, a ligand of beta3-integrin, is maximally expressed around the time of the "implantation window".

  2001cited by this paper

• Modulation of Secondary Cancer Risks from Radiation Exposure by Sex, Age and Gonadal Hormone Status: Progress, Opportunities and Challenges

  2022cites this paper
• Nuclear Medicine Procedures Do Not Pose Cancer Risks in Women—Unappreciated or Otherwise

  2018influential citation
• Nuclear Medicine Procedures Do Not Pose Cancer Risks in Women—Unappreciated or Otherwise

  2018cites this paper