The Chemical Compositions of Angelica pubescens Oil and Its Prevention of UV‐B Radiation‐Induced Cutaneous Photoaging

Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases. However, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti‐photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) ‐B radiation‐induced hairless mice. Overall, we identified and analyzed 93 compounds from the AO by gas chromatography‐mass spectrometry (GC/MS). The top ten compounds were as follows: osthole (44.608%), glutaric acid hexadecyl pent‐4‐en‐1‐yl ester (5.758%), α‐bisabolol (3.795%), eugenol (3.637%), (Z)‐docos‐13‐enamide (3.286%), (3S,3aR)‐3‐butyl‐3a,4,5,6‐tetrahydro‐3H‐2‐benzofuran‐1‐one (3.043%), m‐cresol (2.841%), trans‐sesquisabinene hydrate (2.128%), 4‐hydroxy‐2‐methylacetophenone (1.735%), and (Z)‐9‐pentadecenol (1.509%). Application of AO improved the condition of UV‐B radiation‐induced damaged skin, and the mechanism of action was found to be related to inhibition of the production of inflammatory cytokines. These results highlight the potential application of AO for the development of skin care products.

• Publication year

  2018

• Venue

  Chemistry and Biodiversity

• Publication date

  2018-10-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/cbdv.201800235PMID 29996001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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