Control of chromosomal DNA replication in the early Xenopus embryo

No abstract is available for this paper.

• Publication year

  2001

• Venue

  EMBO Journal

• Publication date

  2001-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/20.13.3293PMID 11432816PMCID PMC125522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

  2001cited by this paper
• Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

  2001cited by this paper
• Replication Origins in XenopusEgg Extract Are 5–15 Kilobases Apart and Are Activated in Clusters That Fire at Different Times

  2001cited by this paper
• The Cdt1 protein is required to license DNA for replication in fission yeast

  2000cited by this paper
• Central role for Cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts

  2000cited by this paper
• The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins.

  2000cited by this paper
• Evidence for Sequential Action of cdc7 and cdk2 Protein Kinases during Initiation of DNA Replication in Xenopus Egg Extracts*

  2000cited by this paper
• XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

  2000cited by this paper
• Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle.

  2000cited by this paper
• Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.

  2000influential reference
• Sequential MCM/P1 Subcomplex Assembly Is Required to Form a Heterohexamer with Replication Licensing Activity*

  2000cited by this paper
• Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

  2000cited by this paper
• Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins.

  1999influential reference
• Replication origins in metazoan chromosomes: fact or fiction?

  1999cited by this paper
• First the CDKs, now the DDKs.

  1999cited by this paper
• Identification of a Preinitiation Step in DNA Replication That Is Independent of Origin Recognition Complex and cdc6, but Dependent on cdk2

  1998cited by this paper
• MCM proteins: evolution, properties, and role in DNA replication.

  1998cited by this paper
• Xenopus Cdc45‐dependent loading of DNA polymerase α onto chromatin under the control of S‐phase cdk

  1998cited by this paper
• Regulated chromosomal DNA replication in the absence of a nucleus.

  1998influential reference
• Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

  1998cited by this paper
• Geminin, an inhibitor of DNA replication, is degraded during mitosis.

  1998cited by this paper
• The RLF‐M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides

  1997cited by this paper
• A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle

  1997cited by this paper
• Cell Cycle Regulation of the Replication Licensing System: Involvement of a Cdk-dependent Inhibitor

  1997cited by this paper
• Licensing of DNA replication by a multi‐protein complex of MCM/P1 proteins in Xenopus eggs

  1997cited by this paper
• Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.

  1997cited by this paper
• Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.

  1997cited by this paper
• The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin.

  1996cited by this paper
• Interaction between the origin recognition complex and the replication licensing system in Xenopus.

  1996influential reference
• Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts.

  1996cited by this paper
• The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts.

  1996cited by this paper
• Role for a Xenopus Orc2-related protein in controlling DNA replication

  1996cited by this paper
• Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.

  1996cited by this paper
• Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor.

  1995cited by this paper
• Purification of an MCM-containing complex as a component of the DNA replication licensing system

  1995cited by this paper
• Maternal Xenopus Cdk2-Cyclin E Complexes Function during Meiotic and Early Embryonic Cell Cycles That Lack a G1 Phase (*)

  1995cited by this paper
• Transition in Specification of Embryonic Metazoan DNA Replication Origins

  1995cited by this paper
• Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.

  1993cited by this paper
• Plasmid replication in Xenopus eggs and egg extracts: a 2D gel electrophoretic analysis.

  1992cited by this paper
• DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts.

  1992cited by this paper
• Cyclin synthesis drives the early embryonic cell cycle

  1989cited by this paper
• A role for the nuclear envelope in controlling DNA replication within the cell cycle

  1988cited by this paper
• Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs.

  1986cited by this paper
• Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplasmic components.

  1983influential reference
• Regulated replication of DNA microinjected into eggs of Xenopus laevis.

  1980cited by this paper
• The units of DNA replication in Drosophila melanogaster chromosomes.

  1974cited by this paper
• The Cdt 1 protein is required to license DNA for replication in ® ssion yeast

  year unknowncited by this paper

• Protocol for the purification of replisomes from the Xenopus laevis egg extract system for single-particle cryo-EM analysis

  2024cites this paper
• Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

  2023cites this paper
• Approaches to Monitor Termination of DNA Replication Using Xenopus Egg Extracts.

  2022cites this paper
• Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer

  2020cites this paper
• Cell-free transcription in Xenopus egg extract

  2019cites this paper
• Direct non transcriptional role of NF-Y in DNA replication.

  2016cites this paper
• Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

  2016cites this paper
• Regulation of Ciz1 by Cyclin A-Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation

  2016cites this paper
• Optimal Origin Placement for Minimal Replication Time

  2015cites this paper
• An oncologist׳s friend: How Xenopus contributes to cancer research

  2015cites this paper
• Blow phosphatase 1 and is counteracted by checkpoint-regulated protein Cdc 7 executes its essential function early in S phase Xenopus

  2013cites this paper
• A Role for USP7 in DNA Replication

  2013cites this paper
• University of Dundee Xenopus Cdc 7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

  2013cites this paper
• Initiation of DNA Replication in the Human Genome.

  2012cites this paper
• Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells

  2012cites this paper
• A general approach to break the concentration barrier in single-molecule imaging

  2012cites this paper
• Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

  2012cites this paper
• The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase

  2012influential citation
• Cdc45 Limits Replicon Usage from a Low Density of preRCs in Mammalian Cells

  2011cites this paper
• DNA is a co-factor for its own replication in Xenopus egg extracts

  2010cites this paper
• Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin

  2010cites this paper
• Structure and function of the GINS complex, a key component of the eukaryotic replisome.

  2010cites this paper
• Structural and biochemical studies of MCM proteins

  2010cites this paper
• GEMC1, a novel factor required for chromosomal DNA replication

  2009cites this paper
• DUE-B, A NEW HUMAN DNA REPLICATION PROTEIN, IS THE FUNCTIONAL HOMOLOG OF S. CEREVISIAE SLD3

  2009cites this paper
• DNA replication in nucleus-free Xenopus egg extracts.

  2009cites this paper
• Temporal Profiling of the Chromatin Proteome Reveals System-wide Responses to Replication Inhibition

  2008cites this paper
• Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells.

  2007cites this paper
• A novel amphibian tier 2 testing protocol: A 30‐week exposure of Xenopus tropicalis to the antiandrogen flutamide

  2007cites this paper
• DNA replication licensing factor minichromosome maintenance deficient 5 rescues p53-mediated growth arrest.

  2007cites this paper
• Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development.

  2007cites this paper
• FROM DNA REPLICATION TO GENOME INSTABILITY IN SCHIZOSACCHAROMYCES POMBE: PATHWAYS TO CANCER

  2007cites this paper
• XRCC1, un élément clef de la réparation des dommages de l'ADN couplée à la réplication

  2007cites this paper
• ELYS/MEL-28 Chromatin Association Coordinates Nuclear Pore Complex Assembly and Replication Licensing

  2007cites this paper
• Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork

  2006cites this paper
• DNA Microarray Applications in Functional Genomics

  2006cites this paper
• ORC is necessary at the interphase-to-mitosis transition to recruit cdc2 kinase and disassemble RPA foci.

  2006cites this paper
• Eukaryotic DNA replication in a chromatin context.

  2006cites this paper
• Characterization of the role of Orc6 in the cell cycle of the budding yeast Saccharomyces cerevisiae

  2006cites this paper
• Multiple Initiation Sites within the Human Ribosomal RNA Gene

  2006cites this paper
• How Xenopus laevis replicates DNA reliably even though its origins of replication are located and initiated stochastically.

  2006cites this paper
• Phase transition as a mechanism of DNA opening for replication and transcription.

  2006cites this paper
• Minichromosome Maintenance Proteins as Markers for Proliferation Zones During Embryogenesis

  2006cites this paper
• Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re‐replication in Xenopus

  2005cites this paper
• Eukaryotic origins of DNA replication: could you please be more specific?

  2005cites this paper
• Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts

  2005cites this paper
• Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.

  2005cites this paper
• Origins of bidirectional replication of Epstein–Barr virus: Models for understanding mammalian origins of DNA synthesis

  2005cites this paper
• Characterization of the cDNA and amino acid sequences of Xenopus Metaxin 3, and relationship to Xenopus Metaxins 1 and 2

  2005cites this paper
• Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination

  2004cites this paper
• The activities of eukaryotic replication origins in chromatin.

  2004cites this paper
• Gene amplification in Drosophila ovarian follicle cells as a developmental strategy and model for metazoan DNA replication

  2004cites this paper
• Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus

  2004influential citation
• DNA replication reaction in Xenopus cell-free system is suppressed by high pressure.

  2004cites this paper
• The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation

  2004cites this paper
• Replication Initiation Eukaryotic MCM Proteins : Beyond

  2004cites this paper
• KINETIC MODEL OF DNA REPLICATION AND THE LOOPING OF SEMIFLEXIBLE POLYMERS

  2004cites this paper
• DNA Unwinding Is an MCM Complex-dependent and ATP Hydrolysis-dependent Process*

  2004cites this paper
• The Regulated Association of Cdt1 with Minichromosome Maintenance Proteins and Cdc6 in Mammalian Cells*

  2004cites this paper
• A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication

  2004cites this paper
• A complex interplay of regulatory domains controls cell cycle dependent subnuclear localization of DNMT1 and is required for the maintenance of epigenetic information

  2004cites this paper
• Eukaryotic MCM Proteins: Beyond Replication Initiation

  2004cites this paper
• Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach

  2004cites this paper
• Negative Regulation of Geminin by CDK-Dependent Ubiquitination Controls Replication Licensing

  2004cites this paper
• Sperm chromatin remodelling and Wolbachia-induced cytoplasmic incompatibility in Drosophila.

  2003cites this paper
• Lats2, a putative tumor suppressor, inhibits G1/S transition

  2003cites this paper
• Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus

  2003cites this paper
• Localization of proteins bound to a replication origin of human DNA along the cell cycle

  2003cites this paper
• Persistence Length of Chromatin Determines Origin Spacing in Xenopus Early-Embryo DNA Replication: Quantitative Comparisons between Theory and Experiment

  2003cites this paper
• Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.

  2002cites this paper
• A approximately 35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP.

  2002cites this paper
• Visualization of replication initiation and elongation in Drosophila

  2002cites this paper
• DNA replication in eukaryotic cells.

  2002cites this paper
• Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.

  2002influential citation
• Cell cycle‐dependent regulation of the association between origin recognition proteins and somatic cell chromatin

  2002cites this paper
• MCM2–7 Complexes Bind Chromatin in a Distributed Pattern Surrounding the Origin Recognition Complex inXenopus Egg Extracts*

  2002cites this paper
• Characterization and changes of a chromosomal-scaffolding protein in human epithelia

  2002cites this paper
• Replication licensing--defining the proliferative state?

  2002cites this paper
• Distinct roles for cyclins E and A during DNA replication complex assembly and activation

  2002cites this paper
• Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.

  2002cites this paper
• Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation.

  2002cites this paper
• Initiation of eukaryotic DNA replication: regulation and mechanisms.

  2002cites this paper
• Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase

  2002cites this paper
• The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells

  2002cites this paper
• Chromatin-associated Proteins in Cultured Human Cells

  2002cites this paper
• The role of DNA polymerases, in particular DNA polymerase ε in DNA repair and replication

  2002cites this paper
• A ~35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP

  2002cites this paper
• Cdc6 synthesis regulates replication competence in Xenopus oocytes

  2002cites this paper
• Growth and Development

  2001cites this paper
• Stability, chromatin association and functional activity of mammalian pre‐replication complex proteins during the cell cycle

  2001cites this paper
• Mammalian G1- and S-phase checkpoints in response to DNA damage.

  2001cites this paper
• The origin of CDK regulation

  2001cites this paper
• Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

  2001cites this paper
• Organization, Replication, Transposition, and Repair of DNA

  2001cites this paper
• Regulation of eukaryotic DNA replication at the initiation step.

  2001cites this paper
• Nearest neighbour analysis of MCM protein complexes in Drosophila melanogaster.

  2001cites this paper
• Mammalian G 1-and S-phase checkpoints in response to DNA damage

  year unknowncites this paper
• 2. Introduction

  year unknowncites this paper
• Subject Collections

  year unknowncites this paper