miR-486 inhibited osteosarcoma cells invasion and epithelial-mesenchymal transition by targeting PIM1

OBJECTIVE: Osteosarcoma is the most common malignant tumor of bone with high recurrent rate. miR-486 was downregulated and acted as a tumor suppressor in plenty of tumors. The purpose of this study was to explore how miR-486 worked in osteosarcoma on cell invasion and EMT. RESULTS: miR-486 was low expressed in osteosarcoma while PIM1 was overexpressed, and it had negative correlation between miR-486 and PIM1. miR-486 upregulation or PIM1 downregulation could inhibit osteosarcoma cell invasion and EMT. Meanwhile, miR-486 mediated PIM1 expression through binding to PIM1 mRNA 3’-UTR. PIM1 could reveal partial function of miR-486 on osteosarcoma invasion. In addition, miR-486 low expression or PIM1 overexpression predicted poor prognosis of osteosarcoma patients. CONCLUSION: miR-486 regulated osteosarcoma cell invasion and EMT through targeting to PIM1. miR-486 low expression or PIM1 overexpression predicted poor prognosis of osteosarcoma patients. The newly identified miR-486/PIM1 axis provides novel insight into the pathogenesis of osteosarcoma.

• Publication year

  2018

• Venue

  Cancer Biomarkers

• Publication date

  2018-05-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.3233/CBM-181527PMID 30103304
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms

  2018cited by this paper
• The miR-486-5p plays a causative role in prostate cancer through negative regulation of multiple tumor suppressor pathways

  2017cited by this paper
• miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway

  2017cited by this paper
• PIM1: a promising target in patients with triple-negative breast cancer

  2017cited by this paper
• MiR-144 functions as tumor suppressor by targeting PIM1 in gastric cancer.

  2017cited by this paper
• miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma

  2017cited by this paper
• miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2

  2017cited by this paper
• PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells.

  2017cited by this paper
• Physcion 8-O-β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1.

  2017cited by this paper
• MiR-486-3p targeting ECM1 represses cell proliferation and metastasis in cervical cancer.

  2016cited by this paper
• miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial–mesenchymal transition

  2016cited by this paper
• PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

  2016cited by this paper
• MicroRNA-638 inhibits cell proliferation by targeting suppress PIM1 expression in human osteosarcoma

  2016cited by this paper
• Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.

  2015cited by this paper
• Osteosarcoma.

  2014cited by this paper
• MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells

  2014cited by this paper
• Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens

  2014cited by this paper
• Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer

  2014cited by this paper
• Osteosarcoma treatment - where do we stand? A state of the art review.

  2014cited by this paper
• For better or for worse: the role of Pim oncogenes in tumorigenesis

  2011cited by this paper
• Osteosarcoma: improvement in survival limited to high-grade patients only

  2011cited by this paper
• Epigenomics and ovarian carcinoma.

  2010cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• The MicroRNA (miRNA): Overview of the RNA Genes that Modulate Gene Function

  2007cited by this paper

• Epithelial–Mesenchymal Transition in Osteosarcoma as a Key Driver of Pulmonary Metastasis

  2025cites this paper
• Autologous hGMSC-Derived iPS: A New Proposal for Tissue Regeneration

  2024cites this paper
• PIM1 signaling in immunoinflammatory diseases: an emerging therapeutic target

  2024cites this paper
• MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

  2024cites this paper
• Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML.

  2023cites this paper
• Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma

  2023cites this paper
• Exosome‑delivered miR‑486‑3p inhibits the progression of osteosarcoma via sponging CircKEAP1/MARCH1 axis components

  2023cites this paper
• Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma

  2022cites this paper
• Dioscin suppresses proliferation and metastasis of osteosarcoma by inhibiting HuR/Pim1 axis via the induction of miR-16-5p level

  2022cites this paper
• Targeting BET Proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

  2022cites this paper
• miR-486-5p inhibits invasion and migration of HTR8/SVneo trophoblast cells by down-regulating ARHGAP5.

  2022cites this paper
• EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA

  2022cites this paper
• Circ_CSPP1 Regulates the Development of Non-small Cell Lung Cancer via the miR-486-3p/BRD9 Axis

  2022cites this paper
• Clinical Significance of Pim-1 in Human Cancers: A Meta-analysis of Association with Prognosis and Clinicopathological Characteristics

  2022cites this paper
• The Role of PIM Kinases in Pediatric Solid Tumors

  2022cites this paper
• Ventilagolin Suppresses Migration, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells by Downregulating Pim-1

  2021cites this paper
• LncRNA SNHG16 promotes epithelial-mesenchymal transition by upregulating ITGA6 through miR-488 inhibition in osteosarcoma

  2021cites this paper
• Design and synthesis of a novel mitochondria-targeted osteosarcoma theranostic agent based on a PIM1 kinase inhibitor.

  2021cites this paper
• Overexpression of microRNA-486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting PIM1

  2021cites this paper
• Prognostic and immunomodulatory effects of PIM1 in colorectal carcinoma.

  2021cites this paper
• The effect of dexmedetomidine on biological behavior of osteosarcoma cells through miR-1307 expression.

  2021cites this paper
• MicroRNA-744-5p Suppresses Tumorigenesis and Metastasis of Osteosarcoma Through the MAPK/ERK Signaling Pathway by Targeting TGFB1

  2021cites this paper
• miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis

  2021cites this paper
• Unravelling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma.

  2021cites this paper
• The Mechanism of Gas Anesthetics Affecting the Proliferation, Invasion and Metastasis of Osteosarcoma Cells and its Chemotherapy Sensitivity

  2021cites this paper
• Role of FUS-CHOP in Myxoid Liposarcoma via miR-486/CDK4 Axis

  2021cites this paper
• miR-216a expression in osteosarcoma tissues and its effect on the proliferation, migration, and autophagy of the osteosarcoma U2OS cell line

  2020cites this paper
• miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling

  2020cites this paper
• Long noncoding RNA PVT1 promotes metastasis via miR-484 sponging in osteosarcoma cells.

  2020cites this paper
• miR-486-5p expression is regulated by DNA methylation in osteosarcoma

  2020cites this paper
• miR-486 expression is regulated by DNA methylation in osteosarcoma regulation of miR-486 in

  2020cites this paper
• miR‑486 acts as an oncogene and potential prognostic biomarker in renal cell carcinoma.

  2019cites this paper
• Overexpression of miR-425-5p is associated with poor prognosis and tumor progression in non-small cell lung cancer

  2019cites this paper