Alkyne-azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors via the PI3K/Akt/NF-kB pathway.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  MedChemComm

• Publication date

  2017-11-16

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1039/c7md00267jPMID 30108729PMCID PMC6072283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E

  2016cited by this paper
• Par‐4 dependent modulation of cellular β‐catenin by medicinal plant natural product derivative 3‐azido Withaferin A

  2016cited by this paper
• An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG).

  2016cited by this paper
• New principle for measuring arterial blood oxygenation, enabling motion-robust remote monitoring

  2016cited by this paper
• Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents.

  2016cited by this paper
• PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells

  2015cited by this paper
• Synthetic modification of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition derivatives depicting cytotoxic potential.

  2015cited by this paper
• Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death.

  2015cited by this paper
• In vitro antifungal activity of dehydrozingerone and its fungitoxic properties.

  2013cited by this paper
• Prostate cancer invasion and metastasis: insights from mining genomic data.

  2013cited by this paper
• A Novel MMP-2 Inhibitor 3-azidowithaferin A (3-azidoWA) Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4

  2012cited by this paper
• Global cancer statistics

  2011cited by this paper
• The PI3K pathway as drug target in human cancer.

  2010cited by this paper
• Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents

  2010cited by this paper
• Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway.

  2010cited by this paper
• Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.

  2007cited by this paper
• Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice.

  2007cited by this paper
• Inhibitory Effect of Dehydrozingerone on Vascular Smooth Muscle Cell Function

  2007cited by this paper
• Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.

  2006cited by this paper
• Constitutive activation of PI3K‐Akt and NF‐κB during prostate cancer progression in autochthonous transgenic mouse model

  2005cited by this paper
• NF-kB in development and progression of human cancer

  2005cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis.

  2000cited by this paper
• Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression*

  2000cited by this paper
• Structure-activity relationship in potentially anti-tumor promoting benzalacetone derivatives, as assayed by the epstein-barr virus early antigen activation.

  2000cited by this paper
• Inhibitory effects of dehydrozingerone and related compounds on 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation.

  1998cited by this paper
• Stability of curcumin in buffer solutions and characterization of its degradation products.

  1997cited by this paper
• Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates

  1994cited by this paper
• Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer.

  1994cited by this paper
• Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

  1988cited by this paper
• Dehydrozingerone from Aframomum giganteum

  1976cited by this paper

• Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibition.

  2025cites this paper
• Integration of click chemistry and graphene driven molecular design: A mechanistic standpoint on targeted cancer therapeutics.

  2025cites this paper
• Anti-Cancer Potential of Dehydrozingerone's Phenoxy-Acetamide Derivatives: Discovery of a Potent Lead with Dual Anti-Proliferative and Anti-Metastatic Activities.

  2025cites this paper
• Dehydrozingerone ameliorates arsenic-induced reproductive toxicity in male Wistar rats

  2024cites this paper
• Synthetic Modification of Dehydrozingerone and Their Biological Evaluation for Anti-Tubercular and Anti-Inflammatory Potency

  2023cites this paper
• Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR.

  2023cites this paper
• RETRACTED: Molecular mechanism of inhibitory effects of melatonin on prostate cancer cell proliferation, migration and invasion

  2022cites this paper
• Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model

  2021cites this paper
• Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways

  2020influential citation
• Anti-inflammatory and analgesic potential of OA-DHZ; a novel semisynthetic derivative of dehydrozingerone.

  2020cites this paper
• A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl

  2020cites this paper
• RRBP1 is highly expressed in prostate cancer and correlates with prognosis

  2019cites this paper
• miR-601 inhibits proliferation, migration and invasion of prostate cancer stem cells by targeting KRT5 to inactivate the Wnt signaling pathway.

  2019cites this paper
• Roles of miR-433-5p in gastric carcinoma cell viability, invasion, and apoptosis via targeting CLCN4 genes

  2019cites this paper
• Anticancer Potential of Dietary Natural Products: A Comprehensive Review.

  2019cites this paper
• Lipoxin A4 inhibited the activation of hepatic stellate cells -T6 cells by modulating profibrotic cytokines and NF-κB signaling pathway.

  2019cites this paper
• CMAR_A_186632 3021..3027

  2019cites this paper
• Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

  2019cites this paper
• Synthesis of 1,5-disubstituted tetrazole-1,2,3 triazoles hybrids via Ugi-azide/CuAAC

  2019cites this paper
• LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma

  2019cites this paper