Pig tracheal patchy xenotransplantation in the dog

T. Lee,Jong-Min Kim,S. Choi

Published 2018 in Xenotransplantation

ABSTRACT

A long‐segmental tracheal lesion is difficult to repair by tracheal allotransplantation due to the lack of a well‐defined blood supply for blood vessel anastomosis. The donor trachea needs to be revascularized within a well‐vascularized soft tissue flap for several months to allow successful trachea allotransplantation. To date, xenotransplantation using the wild‐type or genetically modified pig has been widely studied. The object of this study was to evaluate the feasibility of a small‐sized (2 × 2 cm) wild‐type pig tracheal patchy in a dog tracheal defect model before trying a long‐segment tracheal defect model and using a genetically modified pig as a donor in dog xenotransplantation.

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