Progress in understanding slow inactivation speeds up

A new study reveals that conformational flexibility in the pore of a voltage-gated sodium channel may underlie slow inactivation.

• Publication year

  2018

• Venue

  The Journal of General Physiology

• Publication date

  2018-08-16

• Fields of study

  Biology, Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1085/jgp.201812149PMID 30115663PMCID 6122931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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