Retrospective evaluation of a decision‐support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors

Catherine Goudie,N. Cullinan,A. Villani,Natalie Mathews,Kalene van Engelen,D. Malkin,M. Irwin,W. Foulkes

Published 2018 in Pediatric Blood & Cancer

ABSTRACT

Neuroblastoma is the most common pediatric extracranial solid tumor. Germline pathogenic variants in ALK and PHOX2B, as well as other cancer predisposition genes, are increasingly implicated in the pathogenesis of neuroblastic tumors. A challenge for clinicians is the identification of children with neuroblastoma who require genetics evaluation for underlying cancer predisposition syndromes (CPS).

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