Effects of Taiwanofungus camphoratus on non-specific and specific immune activities in mice

ABSTRACT Taiwanofungus camphoratus is a precious medicinal fungus endemic to Taiwan and has been used as traditional medicine for a long time. Many pharmacological studies have revealed that T. camphoratus possessed various biological activities, such as immunomodulatory effects, anticancer activity and liver protective function. The aim of this study is to investigate the non-specific and antigen (ovalbumin [OVA])-specific immunomodulation effects of solid-state cultivated powder of T. camphoratus (Leader Antrodia cinnamomea [LAC]) in BABL/c male mice. In non-specific and antigen-specific immune function studies, 8-week-old mice were orally administered with LAC for 6 and 8 weeks, respectively. The results have shown that the proliferation of splenic immune cells, phagocytic activity of macrophages and cytolytic activity of natural killer cells were enhanced by LAC. Additionally, LAC increased the levels of IL-2, TNF-α, INF-γ, GM-CSF and serum OVA-IgG and OVA-IgM. These findings provided evidences that LAC had the immunomodulation effects on both antigen-specific and non-specific immune responses in mice.

• Publication year

  2018

• Venue

  Mycology

• Publication date

  2018-02-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/21501203.2018.1437837PMID 30123668PMCID 6059145
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• T Cell Subsets and T Cell-Mediated Immunity

  2019cited by this paper
• In vivo immunomodulatory effect of the lectin from edible mushroom Agaricus bisporus.

  2016cited by this paper
• Targeting cancer initiating cells by promoting cell differentiation and restoring chemosensitivity via dual inactivation of STAT3 and Src activity using an active component of Antrodia cinnamomea mycelia

  2016cited by this paper
• 2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism

  2015cited by this paper
• Antcin K, an Active Triterpenoid from the Fruiting Bodies of Basswood-Cultivated Antrodia cinnamomea, Inhibits Metastasis via Suppression of Integrin-Mediated Adhesion, Migration, and Invasion in Human Hepatoma Cells.

  2015cited by this paper
• The Adjuvant Effects of High-Molecule-Weight Polysaccharides Purified from Antrodia cinnamomea on Dendritic Cell Function and DNA Vaccines

  2015cited by this paper
• Antrodin C Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Suppression of Smad2/3 and β-Catenin Signaling Pathways

  2015cited by this paper
• Immunomodulatory effect of polysaccharides extracted from the medicinal mushroom Antrodia camphorata (higher Basidiomycetes) in specific pathogen-free chickens.

  2014cited by this paper
• Zhankuic Acid A Isolated from Taiwanofungus camphoratus Is a Novel Selective TLR4/MD-2 Antagonist with Anti-Inflammatory Properties

  2014cited by this paper
• Extract of medicinal mushroom Agaricus blazei Murill enhances the non-specific and adaptive immune activities in BALB/c mice.

  2013cited by this paper
• Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism

  2013cited by this paper
• Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).

  2012cited by this paper
• Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea

  2011cited by this paper
• Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds

  2011cited by this paper
• Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.

  2010cited by this paper
• Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms.

  2010cited by this paper
• Purification, cloning, and functional characterization of a novel immunomodulatory protein from Antrodia camphorata (bitter mushroom) that exhibits TLR2-dependent NF-κB activation and M1 polarization within murine macrophages.

  2009cited by this paper
• A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation

  2009cited by this paper
• Immunostimulatory effect of Antrodia camphorata extract on functional maturation of dendritic cells

  2009cited by this paper
• Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate.

  2008influential reference
• In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni.

  2008influential reference
• Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage.

  2008cited by this paper
• Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

  2008influential reference
• Ganoderma lucidum Mycelium and Spore Extracts as Natural Adjuvants for Immunotherapy

  2005cited by this paper
• Overview of interleukin-2 function, production and clinical applications.

  2004cited by this paper
• Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

  2002cited by this paper

• A Botanical Drug Extracted From Antrodia cinnamomea: A First-in-human Phase I Study in Healthy Volunteers.

  2022cites this paper
• A Pilot Study to Assess Food Safety and Potential Cholesterol-Lowering Efficacy of Antrodia cinnamomea Solid-State Cultivated Mycelium in Healthy Adults

  2020cites this paper
• Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats

  2020cites this paper
• The complete mitochondrial genome of medicinal fungus Taiwanofungus camphoratus reveals gene rearrangements and intron dynamics of Polyporales

  2020cites this paper
• Constituents and Anti-Multidrug Resistance Activity of Taiwanofungus camphoratus on Human Cervical Cancer Cells

  2019cites this paper
• Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata

  2019cites this paper
• Immunomodulatory Effects of Fruiting Body Extract and Solid-State-Cultivated Mycelia of Taiwanofungus camphoratus

  2019cites this paper
• Antrodia Cinnamomea Prolongs Survival in a Patient with Small Cell Lung Cancer

  2019cites this paper
• Antrodia camphorata inhibits epithelial‐to‐mesenchymal transition by targeting multiple pathways in triple‐negative breast cancers

  2018cites this paper