CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Cell Transplantation

• Publication date

  1997-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0963-6897(97)00045-6PMID 9331502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice.

  1996cited by this paper
• Large-scale isolation of viable porcine neonatal islet cell (NIC) aggregates.

  1995cited by this paper
• Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.

  1995cited by this paper
• Induction of tolerance in freshly isolated alloreactive T cells by activated T cell stimulators is not due to the absence of CD28-B7 interaction.

  1995cited by this paper
• Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

  1995cited by this paper
• Transplantation tolerance induced by CTLA4-Ig.

  1994cited by this paper
• The ups and downs of T cell costimulation.

  1994cited by this paper
• NOD mouse peritoneal cellular response to poly-L-lysine-alginate microencapsulated rat islets.

  1994cited by this paper
• The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen.

  1994cited by this paper
• Signals and signs for lymphocyte responses.

  1994cited by this paper
• Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.

  1993cited by this paper
• Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

  1993cited by this paper
• Long-term complications of diabetes mellitus.

  1993cited by this paper
• Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.

  1992cited by this paper
• Seminars in medicine of the Beth Israel Hospital, Boston: Pancreatic and islet transplantation for diabetes--cures or curiosities?

  1992cited by this paper
• Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen

  1992cited by this paper
• Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg.

  1992cited by this paper
• Complement receptors.

  1992cited by this paper
• CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

  1992cited by this paper
• EVIDENCE THAT MULTIPLE DEFECTS IN CELL‐SURFACE MOLECULE INTERACTIONS ACROSS SPECIES DIFFERENCES ARE RESPONSIBLE FOR DIMINISHED XENOGENEIC T CELL RESPONSES1

  1992cited by this paper
• Seminars in medicine of the Beth Israel Hospital, Boston: Pancreatic and islet transplantation for diabetes--cures or curiosities?

  1992cited by this paper
• Prolonged functional survival of rat-to-NOD mouse islet xenografts by ultraviolet-B (UV-B) irradiation plus microencapsulation of donor islets.

  1991cited by this paper
• The barrier to xenotransplantation.

  1991cited by this paper
• Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse

  1990cited by this paper
• The role of CD4+ helper T cells in the destruction of microencapsulated islet xenografts in nod mice.

  1990cited by this paper
• Current Status of Clinical Islet Transplantation

  1988cited by this paper
• Xenogeneic transplantation. A review.

  1988cited by this paper
• An Improved Method for the Isolation of Islets from the Beef Pancreas

  1982cited by this paper

• Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques

  2021cites this paper
• Islet transplantation

  2020cites this paper
• Multiple clinically relevant immunotherapies prolong the function of microencapsulated porcine islet xenografts in diabetic NOD mice without the use of anti‐CD154 mAb

  2020cites this paper
• In Vitro Platform Establishes Antigen-Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition

  2019cites this paper
• Bioengineering Strategies for the Treatment of Type I Diabetes.

  2016cites this paper
• Prevention Strategies for Type 1 Diabetes Mellitus

  2012cites this paper
• Gene and Cell Therapies for Diabetes Mellitus

  2012cites this paper
• Long-Term Metabolic Control of Autoimmune Diabetes in Spontaneously Diabetic Nonobese Diabetic Mice by Nonvascularized Microencapsulated Adult Porcine Islets

  2009cites this paper
• CTLA4Ig treatment in patients with multiple sclerosis

  2008cites this paper
• Challenges and emerging technologies in the immunoisolation of cells and tissues.

  2008cites this paper
• Biocompatibility and Immune Acceptance of Adult Porcine Islets Transplanted Intraperitoneally in Diabetic NOD Mice in Calcium Alginate Poly-L-lysine Microcapsules versus Barium Alginate Microcapsules without Poly-L-lysine

  2008cites this paper
• Modulating co-stimulation

  2007cites this paper
• Effect of Microcapsule Composition and Short-Term Immunosuppression on Intraportal Biocompatibility

  2005cites this paper
• The Efficacy of CD40 Ligand Blockade in Discordant Pig-to-Rat Islet Xenotransplantation Is Correlated with an Immunosuppressive Effect of Immunoglobulin

  2005cites this paper
• Inhibition of Cellular Immune Responses to Encapsulated Porcine Islet Xenografts by Simultaneous Blockade of Two Different Costimulatory Pathways

  2005cites this paper
• Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells1

  2004cites this paper
• Nanoporous microsystems for islet cell replacement.

  2004cites this paper
• Humoral immune responses to model antigen co-delivered with biomaterials used in tissue engineering.

  2004cites this paper
• Survival of Microencapsulated Adult Pig Islets in Mice In Spite of an Antibody Response

  2004cites this paper
• The immunobiology of pancreatic islet transplantation.

  2004cites this paper
• Overview of Prevention and Intervention Trials for Type 1 Diabetes

  2003cites this paper
• Indefinite islet protection from autoimmune destruction in nonobese diabetic mice by agarose microencapsulation without immunosuppression1

  2003cites this paper
• Transplantation immunology 2003: simplified approach.

  2003cites this paper
• Clinical islet transplant: current and future directions towards tolerance

  2003cites this paper
• Gene therapy technology applied to disorders of glucose metabolism: promise, achievements, and prospects.

  2003cites this paper
• Tissue Engineering a Heart: Critical Issues

  2003cites this paper
• Co-Stimulatory Molecules in Islet Xenotransplantation: CTLA4Ig Treatment in CD40 Ligand-Deficient Mice

  2002cites this paper
• The LIFE Initiative: Creating Transplant Organs Through Tissue Engineering

  2002cites this paper
• Encapsulation as a strategy for cell xenotransplantation

  2002cites this paper
• Therapeutic strategies for Type 1 and Type 2 diabetes mellitus.

  2002cites this paper
• IMMUNOMODULATION WITH CTLA4-Ig IN ISLET TRANSPLANTATION

  2002cites this paper
• Proliferative and Cytokine Responses in CTLA4-Ig-Treated Diabetic NOD Mice Transplanted with Microencapsulated Neonatal Porcine ICCs

  2002cites this paper
• Gene and cell therapies for diabetes mellitus: strategies and clinical potential.

  2002cites this paper
• Microfabrication technology for pancreatic cell encapsulation

  2002cites this paper
• Non‐Invasive Monitoring of a Bioartificial Pancreas in Vitro and in Vivo

  2001cites this paper
• Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane.

  2001cites this paper
• Bioartificial Pancreas: Materials, Devices, Function, and Limitations

  2001cites this paper
• PORCINE NEONATAL PANCREATIC CELL CLUSTERS IN TISSUE CULTURE: BENEFITS OF SERUM AND IMMOBILIZATION IN ALGINATE HYDROGEL1

  2001cites this paper
• The basis of immunogenicity of endocrine allografts.

  2001cites this paper
• C-Peptide responses after meal challenge in mice transplanted with microencapsulated rat islets

  2001cites this paper
• Immunobiology of cardiac allograft and xenograft transplantation.

  2001cites this paper
• ISLETS IN ALGINATE MACROBEADS REVERSE DIABETES DESPITE MINIMAL ACUTE INSULIN SECRETORY RESPONSES1

  2001cites this paper
• THE USE OF THE ENDOTHELIN RECEPTOR ANTAGONIST, TEZOSENTAN, BEFORE OR AFTER RENAL ISCHEMIA PROTECTS RENAL FUNCTION1

  2001cites this paper
• Cellular Immune Responses to Xenografts

  2001cites this paper
• Development of β-cell Lines for Transplantation in Type 1 Diabetes Mellitus

  2001cites this paper
• Microencapsulation of neonatal porcine islets: protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice.

  2000cites this paper
• Gene therapy for type I diabetes mellitus

  2000cites this paper
• Engineering and material considerations in islet cell transplantation.

  1999cites this paper
• Islet transplantation.

  1999cites this paper
• Article Commentary: Immunoisolation of Cells and Tissues for Transplantation

  1999cites this paper
• Evaluation of Graft‐Host Response for Various Tissue Sources and Animal Models

  1999cites this paper
• Differentiation and Expansion of Beta Cell Mass in Porcine Neonatal Pancreatic Cell Clusters Transplanted into Nude Mice

  1999cites this paper
• Long-Term Survival of Poly-L-Lysine-Alginate Microencapsulated Islet Xenografts in Spontaneously Diabetic NOD Mice

  1999cites this paper
• Induction therapy with new monoclonal antibodies

  1999cites this paper
• Antigen presentation pathways for immunity to islet transplants. Relevance to immunoisolation.

  1999cites this paper
• Antigen Presentation Pathways for Immunity to Islet Transplants: Relevance to Immunoisolation

  1999cites this paper
• Potential Application of Neonatal Porcine Islets as Treatment for Type 1 Diabetes: A Review

  1999cites this paper
• Targeting autoimmune diabetes with gene therapy.

  1999cites this paper
• Transplantation of alginate microcapsules: generation of antibodies against alginates and encapsulated porcine islet-like cell clusters.

  1999cites this paper
• Literature update 1997, part 3

  1998cites this paper
• Prospects for gene therapy of insulin-dependent diabetes mellitus

  1998cites this paper
• Host response to tissue engineered devices.

  1998cites this paper