The species‐spanning family of LPX‐motif harbouring effector proteins

The delivery of effector proteins into infected eukaryotic cells represents a key virulence feature of many microbial pathogens in order to derail essential cellular processes and effectively counter the host defence system. Although bacterial effectors are truly numerous and exhibit a wide range of biochemical activities, commonalities in terms of protein structure and function shared by many bacterial pathogens exist. Recent progress has shed light on a species‐spanning family of bacterial effectors containing an LPX repeat motif as a subtype of the leucine‐rich repeat superfamily, partially combined with a novel E3 ubiquitin ligase domain. This review highlights the immunomodulatory effects of LPX effector proteins, with particular emphasis on the exploitation of the host ubiquitin system.

• Publication year

  2018

• Venue

  Cellular Microbiology

• Publication date

  2018-09-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/cmi.12945PMID 30137651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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