Recent development and trends in sample extraction and preparation for mass spectrometric analysis of nucleotides, nucleosides, and proteins

HighlightsCritical step is sample extraction and preparation in analysis of biomolecules.Materials and techniques are improving for extracting nucleotides and nucleosides.How to analyze and extract the proteins in an exact lesion of diseased tissue. ABSTRACT This review describes the recent developments in sample extraction and preparation techniques for mass spectrometric analysis of nucleotides, nucleosides, and proteins. Unique materials and techniques have been developed for highly selective extraction of nucleotides and nucleosides by solid‐phase extraction strategies using various affinities. However, for proteins, the analysis of small‐scale sections of diseased tissues (formalin‐fixed, paraffin‐embedded tissues) and the direct analysis of an exact lesion on the surface of diseased tissues (liquid extraction surface analysis) have become important advances in this field. In this review, we focus on the latest developments of these techniques and strategies.

• Publication year

  2018

• Venue

  Journal of Pharmaceutical and Biomedical Analysis

• Publication date

  2018-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jpba.2018.08.030PMID 30145449
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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