Fighting obesity by targeting factors regulating beige adipocytes

Purpose of review The current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity. Recent findings We outline recent studies revealing unrecognized mechanisms controlling beige adipocyte physiology, and summarize in particular those that underlie beige thermogenesis independently of classical uncoupling. We also update strategies aimed at fostering beige adipogenesis and white-to beige adipocyte conversion. Finally, we summarize newly identified endogenous secreted factors that promote the thermogenic activation of beige adipocytes and discuss their therapeutic potential. Summary The identification of novel endogenous factors that promote beiging and regulate beige adipocyte-specific physiological pathways opens up new avenues for therapeutic engineering targeting obesity and related metabolic disorders.

• Publication year

  2018

• Venue

  Current opinion in clinical nutrition and metabolic care

• Publication date

  2018-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/MCO.0000000000000509PMID 30148740PMCID PMC6196736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic and epigenetic control of adipose development.

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• The significance of beige and brown fat in humans

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• The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

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• Transcriptional and epigenetic control of brown and beige adipose cell fate and function

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• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis.

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• Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

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• Functional thermogenic beige adipogenesis is inducible in human neck fat

  2014cited by this paper
• Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region.

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• Brown and beige fat: development, function and therapeutic potential

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• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis.

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• The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders

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• BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

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• Recruited brown adipose tissue as an antiobesity agent in humans.

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• Changes in brown adipose tissue in boys and girls during childhood and puberty.

  2012cited by this paper
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

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• FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

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• Angiopoietin-like 4: a decade of research.

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• Relevance of brown adipose tissue in infancy and adolescence

  2012cited by this paper
• Kynurenines in the mammalian brain: when physiology meets pathology

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• Angiopoietin-like 4 (Angptl4) Protein Is a Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes*

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• The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.

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• Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

  2010cited by this paper
• UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

  2010cited by this paper
• High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans

  2009cited by this paper
• New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

  2008cited by this paper
• Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol

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• Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.

  2002cited by this paper
• Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region

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