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Combining autologous bone marrow mononuclear cells seeded on collagen sponge with Nano Hydroxyapatite, and platelet-rich fibrin: Reporting a novel strategy for alveolar cleft bone regeneration.

Hatem H. Al-Ahmady,Ahmad Farouk Abd Elazeem,Nermeen El-moataz Bellah Ahmed,W. Shawkat,Mohamed Elmasry,Mostafa A Abdelrahman,Mohsena Ahmed Abderazik

Published 2018 in Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

ABSTRACT

INTRODUCTION The aim of this study was to examine and assess the use of autologous bone marrow mononuclear cells (BMMNCs) combined with platelet-rich fibrin (PRF) and nanohydroxyapatite for bone regeneration as an effective technique for alveolar cleft repair. PATIENTS AND METHODS This study included 20 patients with unilateral alveolar cleft defects and with an age range of 8-15 years. They were divided equally into two groups: Group A, received treatment via the regenerative approach which includes; autologous BMMNCs seeded on a collagen sponge in combination with nanohydroxyapatite and autologous PRF. Group B, received the standard alveolar bone grafting with iliac crest bone. The effectiveness of the new technique was evaluated and compared to the standard grafting technique through a 12-month follow-up via clinical and radiographic assessments. RESULTS During the 12-month follow-up, Group A exhibited less donor site complications, faster and better soft tissue healing, and less postoperative pain, when compared to group B. 90% of the cases in group A, exhibited complete alveolar bone union verses 70% only in group B. CONCLUSION Combination of BMMNCs, nanohydroxyapatite, and PRF greatly promote bone regeneration in alveolar cleft defects providing an alternative novel therapeutic strategy to the standard alveolar bone grafting.

PUBLICATION RECORD

  • Publication year

    2018

  • Venue

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

  • Publication date

    2018-09-01

  • Fields of study

    Medicine

  • Identifiers
    DOI 10.1016/j.jcms.2018.05.049PMID 30196860
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar, PubMed

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