Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  International Immunopharmacology

• Publication date

  2015-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.intimp.2015.01.005PMID 25601498
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells.

  2014cited by this paper
• Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.

  2013cited by this paper
• Ozone oxidative postconditioning ameliorates joint damage and decreases pro-inflammatory cytokine levels and oxidative stress in PG/PS-induced arthritis in rats.

  2013cited by this paper
• Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal Inflammation

  2013cited by this paper
• Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury.

  2013cited by this paper
• Association of Oxidative DNA Damage and C-Reactive Protein in Women at Risk for Cardiovascular Disease

  2012cited by this paper
• Developmental origins of diabetes: The role of oxidative stress.

  2012cited by this paper
• Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-κB.

  2012cited by this paper
• FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.

  2012cited by this paper
• Novel adipokine fibroblast growth factor 21 is increased in rheumatoid arthritis.

  2012cited by this paper
• A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis.

  2012cited by this paper
• FGF21 reloaded: challenges of a rapidly growing field.

  2011cited by this paper
• Morus bombycis Koidzumi extract suppresses collagen-induced arthritis by inhibiting the activation of nuclear factor-κB and activator protein-1 in mice.

  2011cited by this paper
• FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model

  2010cited by this paper
• Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis.

  2010cited by this paper
• Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride.

  2010cited by this paper
• Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

  2009cited by this paper
• IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen.

  2009cited by this paper
• How antirheumatic drugs protect joints from damage in rheumatoid arthritis.

  2008cited by this paper
• Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B.

  2008cited by this paper
• Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

  2008cited by this paper
• Role of the renin-angiotensin system in vascular inflammation.

  2008cited by this paper
• Evidence that cytokines play a role in rheumatoid arthritis.

  2008cited by this paper
• Collagen-induced arthritis

  2007cited by this paper
• The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

  2007cited by this paper
• Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha.

  2007cited by this paper
• Preclinical models of arthritic disease in non-human primates.

  2007cited by this paper
• Nutrition Journal BioMed Central

  2007cited by this paper
• Cytokines in the pathogenesis of rheumatoid arthritis

  2007cited by this paper
• Thioredoxin protects against joint destruction in a murine arthritis model.

  2006cited by this paper
• Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells

  2005cited by this paper
• Neutrophil-derived cytokines: potential therapeutic targets in inflammation.

  2005cited by this paper
• Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis.

  2005cited by this paper
• Oxidation in rheumatoid arthritis

  2004cited by this paper
• The impact of new biologicals in the treatment of rheumatoid arthritis.

  2004cited by this paper
• Collagen-induced arthritis as a model for rheumatoid arthritis.

  2004cited by this paper
• Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women.

  2003cited by this paper
• Splenectomy attenuates streptococcal cell wall-induced arthritis and alters leukocyte activation.

  2003cited by this paper
• NF-κB: a key role in inflammatory diseases

  2001cited by this paper
• Polymorphonuclear leukocyte adhesion to articular cartilage is inhibited by cartilage surface macromolecules

  2001cited by this paper
• Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by interleukin-1.

  2000cited by this paper
• Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor α

  2000cited by this paper
• Oxidants, oxidative stress and the biology of ageing

  2000cited by this paper
• Oxidant/Antioxidant Status of the Erythrocytes from Patients with Rheumatoid Arthritis

  2000cited by this paper
• Oxidant/antioxidant status of plasma samples from patients with rheumatoid arthritis

  1999cited by this paper
• Collagen-induced arthritis, an animal model of autoimmunity.

  1997cited by this paper
• Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue.

  1996cited by this paper
• Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65.

  1995cited by this paper
• Free radicals, antioxidant enzymes, and carcinogenesis.

  1990cited by this paper

• Research progress on the role of FGF21 in insulin resistance

  2025cites this paper
• Fibroblast Growth Factor 21 Protects Against Cerebral Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis

  2025cites this paper
• Metabolic crosstalk between skeletal muscle and cartilage tissue: insights into myokines in osteoarthritis

  2025cites this paper
• FGF21-engineered ADSCs promote diabetic wound healing by mitigating ferroptosis and oxidative stress via the SIRT1/NRF2/GPX4 signaling pathway

  2025cites this paper
• The value of fibroblast growth factor 21 in health and pathology

  2025cites this paper
• The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?

  2024cites this paper
• The Effect of Endotoxin-Induced Inflammation on the Activity of the Somatotropic Axis in Sheep

  2024cites this paper
• Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health

  2024cites this paper
• Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro.

  2024cites this paper
• NF-κB Signaling Pathway in Rheumatoid Arthritis: Mechanisms and Therapeutic Potential

  2024cites this paper
• Adipokines: masterminds of metabolic inflammation

  2024cites this paper
• Fibroblast growth factor receptor 1 as a potential marker of terminal effector peripheral T helper cells in rheumatoid arthritis patients.

  2023cites this paper
• Interorgan communication with the liver: novel mechanisms and therapeutic targets

  2023cites this paper
• Anti-arthritic and antioxidant effects of trehalose in an experimental model of arthritis.

  2023cites this paper
• "Cerastes snake venom as a promising approach in the management of complete Freund's adjuvant-induced rheumatoid arthritis in rats: Involvement of RANKL and JAK/STAT pathway".

  2023cites this paper
• KLF4 downregulates FGF21 to activate inflammatory injury and oxidative stress of LPS-induced ATDC5 cells via SIRT1/NF-κB/p53 signaling

  2022cites this paper
• Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

  2022cites this paper
• Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis

  2022cites this paper
• Organokines in Rheumatoid Arthritis: A Critical Review

  2022cites this paper
• Leurieus quinquestriatus scorpion venom ameliorates adjuvant-induced arthritis in rats: Modulating JAK/STAT/RANKL signal transduction pathway.

  2022cites this paper
• New developments in the biology of fibroblast growth factors.

  2022cites this paper
• Metformin as a Treatment Strategy for Sjögren’s Syndrome

  2021cites this paper
• Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome

  2021cites this paper
• Pharmacological support to anti-arthritic prospective of physostigmine: a new approach

  2021cites this paper
• The Protective Effects of Protein-Enriched Fraction from Housefly (Musca domestica) against Aged-Related Brain Aging.

  2020cites this paper
• FGF21 Enhances Therapeutic Efficacy and Reduces Side Effects of Dexamethasone in Treatment of Rheumatoid Arthritis

  2020cites this paper
• Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling

  2020cites this paper
• In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice

  2020influential citation
• Lentivirus-Mediated hFGF21 Stable Expression in Liver of Diabetic Rats Model and Its Antidiabetic Effect Observation

  2020influential citation
• FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment.

  2020cites this paper
• FGF21 Enhances Therapeutic Efficacy and Reduces Side Effects of Dexamethasone in Treatment of Rheumatoid Arthritis

  2020cites this paper
• LncRNA-GAS5 Inhibits Expression of miR 103 and Ameliorates the Articular Cartilage in Adjuvant-Induced Arthritis in Obese Mice

  2020cites this paper
• Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning

  2020cites this paper
• The Adipokine Network in Rheumatic Joint Diseases

  2019cites this paper
• Therapeutic Role of Fibroblast Growth Factor 21 (FGF21) in the Amelioration of Chronic Diseases

  2019cites this paper
• Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model

  2019cites this paper
• B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15

  2019cites this paper
• The roles of FGF21 in atherosclerosis pathogenesis

  2019cites this paper
• Emerging role of proprotein convertase subtilisin/kexin type‐9 (PCSK‐9) in inflammation and diseases

  2019cites this paper
• Fibroblast Growth Factor–21 Ameliorates Rheumatoid Arthritis by Maintaining Articular Integrity

  2019cites this paper
• A review of fibroblast growth factor 21 in diabetic cardiomyopathy

  2019cites this paper
• Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice

  2019cites this paper
• Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders.

  2019cites this paper
• Paroxetine and rivastigmine mitigates adjuvant‐induced rheumatoid arthritis in rats: Impact on oxidative stress, apoptosis and RANKL/OPG signals

  2018cites this paper
• Fibroblast growth factor 21 attenuates hypoxia-induced pulmonary hypertension by upregulating PPARγ expression and suppressing inflammatory cytokine levels.

  2018cites this paper
• THE STERATEGIC ROLE OF FIBROBLAST GROWTH FACTOR-21 IN OBESITY

  2018cites this paper
• Improving hyperglycemic effect of FGF‐21 is associated with alleviating inflammatory state in diabetes

  2018cites this paper
• Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation

  2018cites this paper
• FGF21 attenuates pulmonary fibrogenesis through ameliorating oxidative stress in vivo and in vitro.

  2018cites this paper
• Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages.

  2018cites this paper
• FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

  2017cites this paper
• ASOCIACIÓN DE LOS NIVELES SOLUBLES DE LA MOLÉCULA FGF21 CON PERFILES DE CITOCINAS TH1/TH2/TH17 EN PACIENTES CON DIABETES MELLITUS GESTACIONAL

  2017cites this paper
• Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity.

  2017cites this paper
• Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction.

  2017cites this paper
• Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

  2017cites this paper
• Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1.

  2017cites this paper
• Use of immune modulation by human adipose-derived mesenchymal stem cells to treat experimental arthritis in mice.

  2017cites this paper
• Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H 2 O 2-induced premature senescence through SIRT 1

  2017cites this paper
• Granisetron and carvedilol can protect experimental rats against adjuvant-induced arthritis

  2017cites this paper
• Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses.

  2017cites this paper
• FGF21 exerts comparable pharmacological efficacy with Adalimumab in ameliorating collagen-induced rheumatoid arthritis by regulating systematic inflammatory response.

  2017cites this paper
• Treatment of CIA Mice with FGF21 Down-regulates TH17-IL-17 Axis

  2016cites this paper
• Mechanisms mediating the anti-inflammatory effects of dietary methionine restriction

  2016cites this paper
• FGF21 Prospects for Applications in Clinical Practice

  2016cites this paper
• Protective effects of fenofibrate and resveratrol in an aggressive model of rheumatoid arthritis in rats

  2016cites this paper
• Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway.

  2016cites this paper
• The bispecific antibody aimed at the vicious circle of IL-1β and IL-17A, is beneficial for the collagen-induced rheumatoid arthritis of mice through NF-κB signaling pathway.

  2016cites this paper
• The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson's Disease

  2016cites this paper
• Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling

  2015cites this paper
• Oxidative Stress and Human Health

  2015cites this paper
• Protective Effects of Simvastatin and Hesperidin against Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rats

  2015cites this paper
• Immune regulation of metabolic homeostasis in health and disease.

  2015cites this paper
• Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats.

  2015cites this paper