HNF4A (Hepatocyte Nuclear Factor 4 alpha)

Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (Nuclear Receptor Subfamily 2, group A, member 1) is a member of the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. The encoded protein controls the expression of several genes, especially those that play distinct roles in development, differentiation, embryogenesis and organogenesis.

• Publication year

  2018

• Venue

  Atlas of Genetics and Cytogenetics in Oncology and Haematology

• Publication date

  2018-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4267/2042/68157
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Combinatorial regulation of UDP-Glucuronosyltransferase (UGT)-1A8 Gene by Intestinal Factors Cdx2 (Caudal-Related Homeodomain Protein-2) and HNF4a (Hepatocyte Nuclear Factor-4 Alpha)

  2017cited by this paper
• Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer.

  2015cited by this paper
• [Risk of type 2 diabetes with early menarche].

  2014cited by this paper
• Inhibition of hepatitis B Virus replication by hepatocyte nuclear factor 4‐alpha specific short hairpin RNA

  2012cited by this paper
• Edinburgh Research Explorer SUMOylation of HNF4 Regulates Protein Stability and Hepatocyte Function

  2012cited by this paper
• Multiple post-translational modifications in hepatocyte nuclear factor 4α.

  2011cited by this paper
• Nuclear Receptor HNF4α Binding Sequences are Widespread in Alu Repeats

  2011cited by this paper
• Mapping of HNF 4 α target genes in intestinal epithelial cells

  2009cited by this paper
• Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

  2009influential reference
• The Diabetic Phenotype in HNF4A Mutation Carriers Is Moderated By the Expression of HNF4A Isoforms From the P1 Promoter During Fetal Development

  2008cited by this paper
• Transcriptome response of enterocytes to dietary lipids: impact on cell architecture, signaling, and metabolism genes.

  2008cited by this paper
• Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene

  2007cited by this paper
• Tissue-specific transcription factor HNF4α inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 β-cell line

  2007cited by this paper
• Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.

  2007cited by this paper
• Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.

  2006cited by this paper
• Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation.

  2006cited by this paper
• Regulation of the intestinal epithelial barrier by the apical junctional complex

  2006cited by this paper
• Unraveling the complex genetics of familial combined hyperlipidemia

  2006cited by this paper
• Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.

  2006cited by this paper
• Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation.

  2006cited by this paper
• Variants in Hepatocyte Nuclear Factor 4α Are Modestly Associated With Type 2 Diabetes in Pima Indians

  2005cited by this paper
• The Role of HNF 4 A Variants in the Risk of Type 2 Diabetes

  2005cited by this paper
• The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.

  2005cited by this paper
• Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

  2005cited by this paper
• Structural Basis for HNF-4α Activation by Ligand and Coactivator Binding*

  2004cited by this paper
• Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families.

  2002cited by this paper
• Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.

  2002cited by this paper
• Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors.

  2002cited by this paper
• Hepatocyte Nuclear Factor 4α

  2001cited by this paper
• Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.

  2001cited by this paper
• Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.

  2000cited by this paper
• Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4α/MODY1 Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY

  1997cited by this paper
• Severe factor VII deficiency due to a mutation disrupting a hepatocyte nuclear factor 4 binding site in the factor VII promoter.

  1997cited by this paper
• Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4.

  1997cited by this paper
• Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

  1996cited by this paper
• Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

  1990cited by this paper

• HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

  2025cites this paper
• Unveiling the components, physiological functions and emerging trends of hydroxycinnamic acid amides in goji berry (Lycium).

  2025cites this paper
• Balancing metabolism and regeneration in liver diseases through HNF4α targeting.

  2025cites this paper
• A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

  2024cites this paper
• The transcription factor HNF-4α: a key player in haematological disorders

  2021cites this paper
• Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells

  2021cites this paper
• Pro-inflammatory cytokine polymorphisms in ONECUT2 and HNF4A and primary colorectal carcinoma: a post genome-wide gene-lifestyle interaction study.

  2020cites this paper
• HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression

  2020cites this paper
• Molecular pattern of lncRNAs in hepatocellular carcinoma

  2019cites this paper
• Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β

  2019cites this paper
• A feature-based analysis identifies COL1A2 as a regulator in pancreatic cancer

  2019cites this paper