A Novel Osmoprotectant Tear Substitute for the Treatment of Dry Eye Disease

C l i n M e d International Library Citation: Giannaccare G, Fresina M, Versura P(2016) A Novel Osmoprotectant Tear Substitute for the Treatment of Dry Eye Disease. Int J Ophthalmol Clin Res 3:058 Received: April 21, 2016: Accepted: June 03, 2016: Published: July 05, 2016 Copyright: © 2016 Giannaccare G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Giannaccare et al. Int J Ophthalmol Clin Res 2016, 3:058

• Publication year

  2016

• Venue

  Unknown venue

• Publication date

  2016-09-30

• Fields of study

  Medicine

• Identifiers
  DOI 10.23937/2378-346X/1410058
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• In Vivo and Impression Cytology Study on the Effect of Compatible Solutes Eye Drops on the Ocular Surface Epithelial Cell Quality in Dry Eye Patients

  2015cited by this paper
• Artificial tears potpourri: a literature review

  2014cited by this paper
• Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells

  2014cited by this paper
• Decrease in hyperosmotic stress–induced corneal epithelial cell apoptosis by L-carnitine

  2013cited by this paper
• Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting.

  2013cited by this paper
• Efficacy of osmoprotectants on prevention and treatment of murine dry eye.

  2013cited by this paper
• Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress.

  2013cited by this paper
• TearLab® Osmolarity System for diagnosing dry eye

  2013cited by this paper
• Effects of l-Carnitine, Erythritol and Betaine on Pro-inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

  2013cited by this paper
• The role of hyperosmotic stress in inflammation and disease

  2012cited by this paper
• The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface.

  2012cited by this paper
• Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture.

  2011cited by this paper
• Efficacy of Sodium Hyaluronate and Carboxymethylcellulose in Treating Mild to Moderate Dry Eye Disease

  2011cited by this paper
• Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models.

  2011cited by this paper
• Brain volume regulation in response to changes in osmolality.

  2010cited by this paper
• Impression cytology: recent advances and applications in dry eye disease.

  2009cited by this paper
• A link between tear instability and hyperosmolarity in dry eye.

  2009cited by this paper
• Treatment of patients with keratoconjunctivitis sicca with Optive™: results of a multicenter, open-label observational study in Germany

  2008cited by this paper
• Effects of Osmoprotectants on Hyperosmolar Stress in Cultured Human Corneal Epithelial Cells

  2008cited by this paper
• The correlation between the tear film lipid layer and dry eye disease.

  2007cited by this paper
• Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma.

  2007cited by this paper
• Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007).

  2007cited by this paper
• [A new approach for better comprehension of diseases of the ocular surface].

  2007cited by this paper
• The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007).

  2007cited by this paper
• Salt stress effects on the central and carnitine metabolisms of Escherichia coli

  2007cited by this paper
• Mechanisms and Significance of Cell Volume Regulation

  2006cited by this paper
• Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.

  2004cited by this paper
• A Convenient Rabbit Model of Ocular Epithelium Damage Induced by Osmotic Dehydration

  2003cited by this paper
• Cell volume regulation: osmolytes, osmolyte transport, and signal transduction.

  2003cited by this paper
• The Cellular Hydration State: A Critical Determinant for Cell Death and Survival

  2002cited by this paper
• Novel insights into the osmotic stress response of yeast.

  2002cited by this paper
• Osmosensing and osmoregulatory compatible solute accumulation by bacteria.

  2001cited by this paper
• Reliability and validity of the Ocular Surface Disease Index.

  2000influential reference
• Reactive oxygen intermediates are involved in IL-8 production induced by hyperosmotic stress in human bronchial epithelial cells.

  2000cited by this paper
• Carnitine: An osmolyte that plays a metabolic role

  2000cited by this paper
• Hyperosmolarity-induced interleukin-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase.

  1999cited by this paper
• Hyperosmotic stress as a stimulant for proinflammatory cytokine production.

  1997cited by this paper
• Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.

  1995influential reference
• Epithelial cells

  1991cited by this paper
• The measurement of clinical pain intensity: a comparison of six methods

  1986cited by this paper
• Staging of conjunctival squamous metaplasia by impression cytology.

  1985cited by this paper
• Effect of nonisotonic solutions on tear film osmolality.

  1981cited by this paper
• Clinical Ophthalmology Dovepress Dovepress a Prospective, Multicenter, Noninterventional Study of Optive plus ® in the Treatment of Patients with Dry Eye: the Prolipid Study

  year unknowncited by this paper
• Clinical Ophthalmology Dovepress

  year unknowncited by this paper

• A contact lens-embedded betaine ester polymer for pH-responsive release of an osmoprotectant to the corneal surface.

  2026cites this paper
• A Critical Appraisal of the Physicochemical Properties and Biological Effects of Artificial Tear Ingredients and Formulations

  2023cites this paper
• Current trends in pharmaceutical treatment of Dry Eye Disease: A review.

  2022cites this paper
• Formulation Considerations for the Management of Dry Eye Disease

  2021cites this paper
• Categorization of Marketed Artificial Tear Formulations Based on Their Ingredients: A Rational Approach for Their Use

  2021cites this paper
• Safety and Efficacy of a Preservative-Free Artificial Tear Containing Carboxymethylcellulose and Hyaluronic Acid for Dry Eye Disease: A Randomized, Controlled, Multicenter 3-Month Study

  2020cites this paper
• Safety and Efficacy of a Preservative-Free Artificial Tear Containing Carboxymethylcellulose and Hyaluronic Acid for Dry Eye Disease: A Randomized, Controlled, Multicenter 3-Month Study

  2020cites this paper
• Safety and Efficacy of a Preservative-Free Artificial Tear Containing Carboxymethylcellulose and Hyaluronic Acid for Dry Eye Disease: A Randomized, Controlled, Multicenter 3-Month Study

  2020cites this paper
• Review of Biomarkers in Ocular Matrices: Challenges and Opportunities

  2019cites this paper
• Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices.

  2017cites this paper