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Prognostic role of long non-coding RNA HNF1A-AS1 in Chinese cancer patients: a meta-analysis

Chunbo Zhuang,Lei Zheng,Pei Wang

Published 2018 in OncoTargets and Therapy

ABSTRACT

Background Long non-coding RNAs (LncRNAs) play important roles in tumorigenesis and progression. Recent studies have demonstrated that LncRNA HNF1A antisense RNA 1 (HNF1A-AS1) is aberrantly expressed in several types of cancers and is associated with poor outcomes. This meta-analysis was conducted to investigate the relationship between HNF1A-AS1 expression and clinical outcomes in cancer patients. Methods We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang databases (updated until December 31, 2017) for literature. A total of eight studies with 789 cancer patients were finally included in the present meta-analysis. Results The results showed that high expression of HNF1A-AS1 significantly predicted poor overall survival (HR=3.10, 95% CI: 1.58–6.11, P=0.001), which was further validated using The Cancer Genome Atlas (TCGA) dataset. Moreover, high HNF1A-AS1 expression was also associated with advanced TNM stage (OR=3.32, 95% CI: 2.28–4.83, P<0.001), lymph node metastasis (OR=3.08, 95% CI: 1.95–4.85, P<0.001), and distant metastasis (OR=5.53, 95% CI: 1.94–15.77, P=0.001). Conclusion Our results suggested that elevated HNF1A-AS1 was associated with poor clinical outcomes and might serve as a potential prognostic biomarker of cancer.

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